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Comparative analysis of mechanical and dissolution properties of single- and multicomponent folic acid supplements

Authorized Users Only
2017
Authors
Đuriš, Jelena
Čalija, Bojan
Vidović, Bojana
Dobričić, Vladimir
Milić, Jela
Ibrić, Svetlana
Article (Published version)
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Abstract
Previous reports revealed several concerns related to the quality of marketed folic acid dietary supplements with potential influence on their efficacy, such as underdosages of the folic acid content, complexity of composition and the failure to meet the disintegration and/or dissolution requirements. This study was aimed to compare various marketed folic acid supplements, formulated as single- or multicomponent products, by testing their weight variation, friability, hardness, disintegration and dissolution properties according to the compendial requirements; accompanied with the investigation of influence of composition on the dosage form properties. The obtained results revealed significant differences in mechanical and dissolution properties between the tested supplements, especially between the single- and multicomponent products, where most of the multicomponent products failed to meet the compendial requirements for either dissolution or disintegration. These findings indicate t...he need for harmonized and strict regulatory requirements for the quality of multicomponent dietary supplements.

Keywords:
Folic acid / Dietary supplements / Composition / Dissolution / Disintegration / Hardness / Dosage forms / Food analysis / Food composition
Source:
Journal of Food Composition and Analysis, 2017, 60, 17-24
Publisher:
  • Academic Press Inc Elsevier Science, San Diego
Projects:
  • Advanced technologies for controlled release from solid drug delivery systems (RS-34007)

DOI: 10.1016/j.jfca.2017.03.005

ISSN: 0889-1575

WoS: 000402356800003

Scopus: 2-s2.0-85017184944
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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/3010
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  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy

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