Previous reports revealed several concerns related to the quality of marketed folic acid dietary supplements with potential influence on their efficacy, such as underdosages of the folic acid content, complexity of composition and the failure to meet the disintegration and/or dissolution requirements. This study was aimed to compare various marketed folic acid supplements, formulated as single- or multicomponent products, by testing their weight variation, friability, hardness, disintegration and dissolution properties according to the compendial requirements; accompanied with the investigation of influence of composition on the dosage form properties. The obtained results revealed significant differences in mechanical and dissolution properties between the tested supplements, especially between the single- and multicomponent products, where most of the multicomponent products failed to meet the compendial requirements for either dissolution or disintegration. These findings indicate t...he need for harmonized and strict regulatory requirements for the quality of multicomponent dietary supplements.
TY - JOUR
AU - Đuriš, Jelena
AU - Čalija, Bojan
AU - Vidović, Bojana
AU - Dobričić, Vladimir
AU - Milić, Jela
AU - Ibrić, Svetlana
PY - 2017
UR - http://farfar.pharmacy.bg.ac.rs/handle/123456789/3010
AB - Previous reports revealed several concerns related to the quality of marketed folic acid dietary supplements with potential influence on their efficacy, such as underdosages of the folic acid content, complexity of composition and the failure to meet the disintegration and/or dissolution requirements. This study was aimed to compare various marketed folic acid supplements, formulated as single- or multicomponent products, by testing their weight variation, friability, hardness, disintegration and dissolution properties according to the compendial requirements; accompanied with the investigation of influence of composition on the dosage form properties. The obtained results revealed significant differences in mechanical and dissolution properties between the tested supplements, especially between the single- and multicomponent products, where most of the multicomponent products failed to meet the compendial requirements for either dissolution or disintegration. These findings indicate the need for harmonized and strict regulatory requirements for the quality of multicomponent dietary supplements.
PB - Academic Press Inc Elsevier Science, San Diego
T2 - Journal of Food Composition and Analysis
T1 - Comparative analysis of mechanical and dissolution properties of single- and multicomponent folic acid supplements
VL - 60
SP - 17
EP - 24
DO - 10.1016/j.jfca.2017.03.005
UR - conv_3859
ER -
@article{
author = "Đuriš, Jelena and Čalija, Bojan and Vidović, Bojana and Dobričić, Vladimir and Milić, Jela and Ibrić, Svetlana",
year = "2017",
abstract = "Previous reports revealed several concerns related to the quality of marketed folic acid dietary supplements with potential influence on their efficacy, such as underdosages of the folic acid content, complexity of composition and the failure to meet the disintegration and/or dissolution requirements. This study was aimed to compare various marketed folic acid supplements, formulated as single- or multicomponent products, by testing their weight variation, friability, hardness, disintegration and dissolution properties according to the compendial requirements; accompanied with the investigation of influence of composition on the dosage form properties. The obtained results revealed significant differences in mechanical and dissolution properties between the tested supplements, especially between the single- and multicomponent products, where most of the multicomponent products failed to meet the compendial requirements for either dissolution or disintegration. These findings indicate the need for harmonized and strict regulatory requirements for the quality of multicomponent dietary supplements.",
publisher = "Academic Press Inc Elsevier Science, San Diego",
journal = "Journal of Food Composition and Analysis",
title = "Comparative analysis of mechanical and dissolution properties of single- and multicomponent folic acid supplements",
volume = "60",
pages = "17-24",
doi = "10.1016/j.jfca.2017.03.005",
url = "conv_3859"
}
Đuriš, J., Čalija, B., Vidović, B., Dobričić, V., Milić, J.,& Ibrić, S.. (2017). Comparative analysis of mechanical and dissolution properties of single- and multicomponent folic acid supplements. in Journal of Food Composition and Analysis
Academic Press Inc Elsevier Science, San Diego., 60, 17-24.
https://doi.org/10.1016/j.jfca.2017.03.005
conv_3859
Đuriš J, Čalija B, Vidović B, Dobričić V, Milić J, Ibrić S. Comparative analysis of mechanical and dissolution properties of single- and multicomponent folic acid supplements. in Journal of Food Composition and Analysis. 2017;60:17-24.
doi:10.1016/j.jfca.2017.03.005
conv_3859 .
Đuriš, Jelena, Čalija, Bojan, Vidović, Bojana, Dobričić, Vladimir, Milić, Jela, Ibrić, Svetlana, "Comparative analysis of mechanical and dissolution properties of single- and multicomponent folic acid supplements" in Journal of Food Composition and Analysis, 60 (2017):17-24,
https://doi.org/10.1016/j.jfca.2017.03.005 .,
conv_3859 .
