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dc.creatorĐuriš, Jelena
dc.creatorČalija, Bojan
dc.creatorVidović, Bojana
dc.creatorDobričić, Vladimir
dc.creatorMilić, Jela
dc.creatorIbrić, Svetlana
dc.date.accessioned2019-09-02T12:02:34Z
dc.date.available2019-09-02T12:02:34Z
dc.date.issued2017
dc.identifier.issn0889-1575
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/3010
dc.description.abstractPrevious reports revealed several concerns related to the quality of marketed folic acid dietary supplements with potential influence on their efficacy, such as underdosages of the folic acid content, complexity of composition and the failure to meet the disintegration and/or dissolution requirements. This study was aimed to compare various marketed folic acid supplements, formulated as single- or multicomponent products, by testing their weight variation, friability, hardness, disintegration and dissolution properties according to the compendial requirements; accompanied with the investigation of influence of composition on the dosage form properties. The obtained results revealed significant differences in mechanical and dissolution properties between the tested supplements, especially between the single- and multicomponent products, where most of the multicomponent products failed to meet the compendial requirements for either dissolution or disintegration. These findings indicate the need for harmonized and strict regulatory requirements for the quality of multicomponent dietary supplements.en
dc.publisherAcademic Press Inc Elsevier Science, San Diego
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/34007/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Food Composition and Analysis
dc.subjectFolic aciden
dc.subjectDietary supplementsen
dc.subjectCompositionen
dc.subjectDissolutionen
dc.subjectDisintegrationen
dc.subjectHardnessen
dc.subjectDosage formsen
dc.subjectFood analysisen
dc.subjectFood compositionen
dc.titleComparative analysis of mechanical and dissolution properties of single- and multicomponent folic acid supplementsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractИбрић, Светлана; Видовић, Бојана; Милић, Јела; Добричић, Владимир; Ђуриш, Јелена; Чалија, Бојан;
dc.citation.volume60
dc.citation.spage17
dc.citation.epage24
dc.citation.other60: 17-24
dc.citation.rankM21
dc.identifier.wos000402356800003
dc.identifier.doi10.1016/j.jfca.2017.03.005
dc.identifier.scopus2-s2.0-85017184944
dc.identifier.rcubconv_3859
dc.type.versionpublishedVersion


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