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The association of enzymatic and non-enzymatic antioxidant defense parameters with inflammatory markers in patients with exudative form of age-related macular degeneration

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2017
3009.pdf (507.6Kb)
Authors
Colak, Emina
Ignjatović, Svetlana
Radosavljević, Aleksandra
Zorić, Lepsa
Article (Published version)
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Abstract
There are evidence that oxidative stress and inflammation are involved in the pathogenesis of the age-related macular degeneration (AMD). The aim of this study was to analyze the antioxidant defense parameters and inflammatory markers in patients with exudative form of AMD (eAMD), their mutual correlations and association with the specific forms of AMD. The cross-sectional study, included 75 patients with the eAMD, 31 patients with the early form, and 87 aged-matched control subjects. Significantly lower SOD, TAS and albumin values and higher GR, CRP and IL-6 were found in the eAMD compared to the early form (p lt 0.05). Significant negative correlations were found between GPx and fibrinogen (r = -0.254), TAS and IL-6 (r = -0.999) and positive correlations between uric acid and CRP (r = 0.292), IL-6 and uric acid (r = 0.398) in the eAMD. A significant association of CRP (OR: 1.16, 95% CI: 1.03-1.32, p = 0.018), fibrinogen (OR: 2.21, 95% CI: 1.14-4.85, p = 0.021), TAS (OR: 7.45, 95% CI:... 3.97-14.35, p = 0.0001), albumin (OR: 1.25, 95% CI: 1.11-1.41, p = 0.0001) and uric acid (OR: 1.006, 95% CI: 1.00-1.02, p = 0.003) was found with the eAMD. In conclusion it may be suggested, there is a significant impairment of antioxidant and inflammatory parameter levels in eAMD patients. In addition, significant association exists between the tested inflammatory markers and antioxidant parameters with late-eAMD.

Source:
Journal of Clinical Biochemistry and Nutrition, 2017, 60, 2, 100-107
Publisher:
  • Journal Clinical Biochemistry & Nutrition, Kyoto
Funding / projects:
  • Biomarkers of organ damage and dysfunction (RS-175036)

DOI: 10.3164/jcbn.16-30

ISSN: 0912-0009

PubMed: 28366988

WoS: 000400040200004

Scopus: 2-s2.0-85014491754
[ Google Scholar ]
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13
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/3011
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Colak, Emina
AU  - Ignjatović, Svetlana
AU  - Radosavljević, Aleksandra
AU  - Zorić, Lepsa
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3011
AB  - There are evidence that oxidative stress and inflammation are involved in the pathogenesis of the age-related macular degeneration (AMD). The aim of this study was to analyze the antioxidant defense parameters and inflammatory markers in patients with exudative form of AMD (eAMD), their mutual correlations and association with the specific forms of AMD. The cross-sectional study, included 75 patients with the eAMD, 31 patients with the early form, and 87 aged-matched control subjects. Significantly lower SOD, TAS and albumin values and higher GR, CRP and IL-6 were found in the eAMD compared to the early form (p lt 0.05). Significant negative correlations were found between GPx and fibrinogen (r = -0.254), TAS and IL-6 (r = -0.999) and positive correlations between uric acid and CRP (r = 0.292), IL-6 and uric acid (r = 0.398) in the eAMD. A significant association of CRP (OR: 1.16, 95% CI: 1.03-1.32, p = 0.018), fibrinogen (OR: 2.21, 95% CI: 1.14-4.85, p = 0.021), TAS (OR: 7.45, 95% CI: 3.97-14.35, p = 0.0001), albumin (OR: 1.25, 95% CI: 1.11-1.41, p = 0.0001) and uric acid (OR: 1.006, 95% CI: 1.00-1.02, p = 0.003) was found with the eAMD. In conclusion it may be suggested, there is a significant impairment of antioxidant and inflammatory parameter levels in eAMD patients. In addition, significant association exists between the tested inflammatory markers and antioxidant parameters with late-eAMD.
PB  - Journal Clinical Biochemistry & Nutrition, Kyoto
T2  - Journal of Clinical Biochemistry and Nutrition
T1  - The association of enzymatic and non-enzymatic antioxidant defense parameters with inflammatory markers in patients with exudative form of age-related macular degeneration
VL  - 60
IS  - 2
SP  - 100
EP  - 107
DO  - 10.3164/jcbn.16-30
ER  - 
@article{
author = "Colak, Emina and Ignjatović, Svetlana and Radosavljević, Aleksandra and Zorić, Lepsa",
year = "2017",
abstract = "There are evidence that oxidative stress and inflammation are involved in the pathogenesis of the age-related macular degeneration (AMD). The aim of this study was to analyze the antioxidant defense parameters and inflammatory markers in patients with exudative form of AMD (eAMD), their mutual correlations and association with the specific forms of AMD. The cross-sectional study, included 75 patients with the eAMD, 31 patients with the early form, and 87 aged-matched control subjects. Significantly lower SOD, TAS and albumin values and higher GR, CRP and IL-6 were found in the eAMD compared to the early form (p lt 0.05). Significant negative correlations were found between GPx and fibrinogen (r = -0.254), TAS and IL-6 (r = -0.999) and positive correlations between uric acid and CRP (r = 0.292), IL-6 and uric acid (r = 0.398) in the eAMD. A significant association of CRP (OR: 1.16, 95% CI: 1.03-1.32, p = 0.018), fibrinogen (OR: 2.21, 95% CI: 1.14-4.85, p = 0.021), TAS (OR: 7.45, 95% CI: 3.97-14.35, p = 0.0001), albumin (OR: 1.25, 95% CI: 1.11-1.41, p = 0.0001) and uric acid (OR: 1.006, 95% CI: 1.00-1.02, p = 0.003) was found with the eAMD. In conclusion it may be suggested, there is a significant impairment of antioxidant and inflammatory parameter levels in eAMD patients. In addition, significant association exists between the tested inflammatory markers and antioxidant parameters with late-eAMD.",
publisher = "Journal Clinical Biochemistry & Nutrition, Kyoto",
journal = "Journal of Clinical Biochemistry and Nutrition",
title = "The association of enzymatic and non-enzymatic antioxidant defense parameters with inflammatory markers in patients with exudative form of age-related macular degeneration",
volume = "60",
number = "2",
pages = "100-107",
doi = "10.3164/jcbn.16-30"
}
Colak, E., Ignjatović, S., Radosavljević, A.,& Zorić, L.. (2017). The association of enzymatic and non-enzymatic antioxidant defense parameters with inflammatory markers in patients with exudative form of age-related macular degeneration. in Journal of Clinical Biochemistry and Nutrition
Journal Clinical Biochemistry & Nutrition, Kyoto., 60(2), 100-107.
https://doi.org/10.3164/jcbn.16-30
Colak E, Ignjatović S, Radosavljević A, Zorić L. The association of enzymatic and non-enzymatic antioxidant defense parameters with inflammatory markers in patients with exudative form of age-related macular degeneration. in Journal of Clinical Biochemistry and Nutrition. 2017;60(2):100-107.
doi:10.3164/jcbn.16-30 .
Colak, Emina, Ignjatović, Svetlana, Radosavljević, Aleksandra, Zorić, Lepsa, "The association of enzymatic and non-enzymatic antioxidant defense parameters with inflammatory markers in patients with exudative form of age-related macular degeneration" in Journal of Clinical Biochemistry and Nutrition, 60, no. 2 (2017):100-107,
https://doi.org/10.3164/jcbn.16-30 . .

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