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dc.creatorColak, Emina
dc.creatorIgnjatović, Svetlana
dc.creatorRadosavljević, Aleksandra
dc.creatorZorić, Lepsa
dc.date.accessioned2019-09-02T12:02:35Z
dc.date.available2019-09-02T12:02:35Z
dc.date.issued2017
dc.identifier.issn0912-0009
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/3011
dc.description.abstractThere are evidence that oxidative stress and inflammation are involved in the pathogenesis of the age-related macular degeneration (AMD). The aim of this study was to analyze the antioxidant defense parameters and inflammatory markers in patients with exudative form of AMD (eAMD), their mutual correlations and association with the specific forms of AMD. The cross-sectional study, included 75 patients with the eAMD, 31 patients with the early form, and 87 aged-matched control subjects. Significantly lower SOD, TAS and albumin values and higher GR, CRP and IL-6 were found in the eAMD compared to the early form (p lt 0.05). Significant negative correlations were found between GPx and fibrinogen (r = -0.254), TAS and IL-6 (r = -0.999) and positive correlations between uric acid and CRP (r = 0.292), IL-6 and uric acid (r = 0.398) in the eAMD. A significant association of CRP (OR: 1.16, 95% CI: 1.03-1.32, p = 0.018), fibrinogen (OR: 2.21, 95% CI: 1.14-4.85, p = 0.021), TAS (OR: 7.45, 95% CI: 3.97-14.35, p = 0.0001), albumin (OR: 1.25, 95% CI: 1.11-1.41, p = 0.0001) and uric acid (OR: 1.006, 95% CI: 1.00-1.02, p = 0.003) was found with the eAMD. In conclusion it may be suggested, there is a significant impairment of antioxidant and inflammatory parameter levels in eAMD patients. In addition, significant association exists between the tested inflammatory markers and antioxidant parameters with late-eAMD.en
dc.publisherJournal Clinical Biochemistry & Nutrition, Kyoto
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175036/RS//
dc.rightsopenAccess
dc.sourceJournal of Clinical Biochemistry and Nutrition
dc.titleThe association of enzymatic and non-enzymatic antioxidant defense parameters with inflammatory markers in patients with exudative form of age-related macular degenerationen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЦолак, Емина; Зорић, Лепса; Радосављевић, Aлександра; Игњатовић, Светлана;
dc.citation.volume60
dc.citation.issue2
dc.citation.spage100
dc.citation.epage107
dc.citation.other60(2): 100-107
dc.citation.rankM23
dc.identifier.wos000400040200004
dc.identifier.doi10.3164/jcbn.16-30
dc.identifier.pmid28366988
dc.identifier.scopus2-s2.0-85014491754
dc.identifier.fulltexthttps://farfar.pharmacy.bg.ac.rs//bitstream/id/1618/3009.pdf
dc.identifier.rcubconv_3837
dc.type.versionpublishedVersion


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