Influence of selected mobile phase properties on the TLC retention behavior of ziprasidone and its impurities
Abstract
Influence of nine different solvents, either alone or in a mixture, on the retention behavior of ziprasidone and its five impurities were examined by normal-phase thin-layer chromatography. Migration distances of the examined compounds obtained under the examined chromatographic conditions were correlated with calculated mobile phase properties, such as Snyder polarity and Hansen solubility. Linear or second-order polynomial relationships with high correlation coefficients were established between investigated variables. The obtained mathematical functions and statistical results indicated that selected mobile phase properties can be used for the prediction of the retention behavior of ziprasidone and its five impurities. [GRAPHICS] .
Source:
Journal of Liquid Chromatography & Related Technologies, 2017, 40, 5-6, 247-251Publisher:
- Taylor & Francis Inc, Philadelphia
Funding / projects:
DOI: 10.1080/10826076.2017.1298026
ISSN: 1082-6076
WoS: 000401995700005
Scopus: 2-s2.0-85017157882
Collections
Institution/Community
PharmacyTY - JOUR AU - Obradović, Darija AU - Oljačić, Slavica AU - Nikolić, Katarina AU - Agbaba, Danica PY - 2017 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3016 AB - Influence of nine different solvents, either alone or in a mixture, on the retention behavior of ziprasidone and its five impurities were examined by normal-phase thin-layer chromatography. Migration distances of the examined compounds obtained under the examined chromatographic conditions were correlated with calculated mobile phase properties, such as Snyder polarity and Hansen solubility. Linear or second-order polynomial relationships with high correlation coefficients were established between investigated variables. The obtained mathematical functions and statistical results indicated that selected mobile phase properties can be used for the prediction of the retention behavior of ziprasidone and its five impurities. [GRAPHICS] . PB - Taylor & Francis Inc, Philadelphia T2 - Journal of Liquid Chromatography & Related Technologies T1 - Influence of selected mobile phase properties on the TLC retention behavior of ziprasidone and its impurities VL - 40 IS - 5-6 SP - 247 EP - 251 DO - 10.1080/10826076.2017.1298026 ER -
@article{ author = "Obradović, Darija and Oljačić, Slavica and Nikolić, Katarina and Agbaba, Danica", year = "2017", abstract = "Influence of nine different solvents, either alone or in a mixture, on the retention behavior of ziprasidone and its five impurities were examined by normal-phase thin-layer chromatography. Migration distances of the examined compounds obtained under the examined chromatographic conditions were correlated with calculated mobile phase properties, such as Snyder polarity and Hansen solubility. Linear or second-order polynomial relationships with high correlation coefficients were established between investigated variables. The obtained mathematical functions and statistical results indicated that selected mobile phase properties can be used for the prediction of the retention behavior of ziprasidone and its five impurities. [GRAPHICS] .", publisher = "Taylor & Francis Inc, Philadelphia", journal = "Journal of Liquid Chromatography & Related Technologies", title = "Influence of selected mobile phase properties on the TLC retention behavior of ziprasidone and its impurities", volume = "40", number = "5-6", pages = "247-251", doi = "10.1080/10826076.2017.1298026" }
Obradović, D., Oljačić, S., Nikolić, K.,& Agbaba, D.. (2017). Influence of selected mobile phase properties on the TLC retention behavior of ziprasidone and its impurities. in Journal of Liquid Chromatography & Related Technologies Taylor & Francis Inc, Philadelphia., 40(5-6), 247-251. https://doi.org/10.1080/10826076.2017.1298026
Obradović D, Oljačić S, Nikolić K, Agbaba D. Influence of selected mobile phase properties on the TLC retention behavior of ziprasidone and its impurities. in Journal of Liquid Chromatography & Related Technologies. 2017;40(5-6):247-251. doi:10.1080/10826076.2017.1298026 .
Obradović, Darija, Oljačić, Slavica, Nikolić, Katarina, Agbaba, Danica, "Influence of selected mobile phase properties on the TLC retention behavior of ziprasidone and its impurities" in Journal of Liquid Chromatography & Related Technologies, 40, no. 5-6 (2017):247-251, https://doi.org/10.1080/10826076.2017.1298026 . .