The association between retinol-binding protein 4 and cardiovascular risk score is mediated by waist circumference in overweight/obese adolescent girls
2017
Authors
Klisić, AleksandraKavarić, Nebojša
Bjelaković, Bojko
Soldatović, Ivan
Martinović, Milica
Kotur-Stevuljević, Jelena
Article (Published version)
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Retinol-binding protein 4 (RBP4) is an emerging risk factor for atherosclerotic disease in adults. However, to our knowledge, there are no studies examining the relationship between RBP4 and cardiovascular risk in young population. Therefore, we aimed to estimate this potential relationship in overweight/obese adolescent girls. Seventy overweight/obese adolescent girls, mean age 17.6 +/- 1.20 years, were included. Anthropometric and biochemical parameters were measured. Cardiovascular risk score (CVRS) was calculated by adding points for each risk factor (e.g., sex, high-density lipoprotein cholesterol (HDL-c), non-HDL-c, smoking, blood pressure and fasting glycemia). According to the risk status, we divided adolescent girls into low, medium and high risk groups (-2 lt = CVRS lt = 1, 2 lt = CVRS 54 and CVRS >= 5, respectively). We found significantly higher RBP4 in the high risk group as compared with low risk group (p lt 0.001). However, multiple linear regression analysis showed w...aist circumference (beta=0.257, p=0.031) to be the only independent predictor of higher cardiovascular risk (adjusted R'=0.342, p lt 0.001). In conclusion, RBP4 may be associated with higher cardiovascular risk in overweight/obese adolescent girls, but this association is mediated by abdominal obesity.
Source:
Acta Clinica Croatica, 2017, 56, 1, 92-98Publisher:
- Sestre Milosrdnice Univ Hospital, Zagreb
Funding / projects:
DOI: 10.20471/acc.2017.56.01.14
ISSN: 0353-9466
PubMed: 29120147
WoS: 000401782900014
Scopus: 2-s2.0-85024871721
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PharmacyTY - JOUR AU - Klisić, Aleksandra AU - Kavarić, Nebojša AU - Bjelaković, Bojko AU - Soldatović, Ivan AU - Martinović, Milica AU - Kotur-Stevuljević, Jelena PY - 2017 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3017 AB - Retinol-binding protein 4 (RBP4) is an emerging risk factor for atherosclerotic disease in adults. However, to our knowledge, there are no studies examining the relationship between RBP4 and cardiovascular risk in young population. Therefore, we aimed to estimate this potential relationship in overweight/obese adolescent girls. Seventy overweight/obese adolescent girls, mean age 17.6 +/- 1.20 years, were included. Anthropometric and biochemical parameters were measured. Cardiovascular risk score (CVRS) was calculated by adding points for each risk factor (e.g., sex, high-density lipoprotein cholesterol (HDL-c), non-HDL-c, smoking, blood pressure and fasting glycemia). According to the risk status, we divided adolescent girls into low, medium and high risk groups (-2 lt = CVRS lt = 1, 2 lt = CVRS 54 and CVRS >= 5, respectively). We found significantly higher RBP4 in the high risk group as compared with low risk group (p lt 0.001). However, multiple linear regression analysis showed waist circumference (beta=0.257, p=0.031) to be the only independent predictor of higher cardiovascular risk (adjusted R'=0.342, p lt 0.001). In conclusion, RBP4 may be associated with higher cardiovascular risk in overweight/obese adolescent girls, but this association is mediated by abdominal obesity. PB - Sestre Milosrdnice Univ Hospital, Zagreb T2 - Acta Clinica Croatica T1 - The association between retinol-binding protein 4 and cardiovascular risk score is mediated by waist circumference in overweight/obese adolescent girls VL - 56 IS - 1 SP - 92 EP - 98 DO - 10.20471/acc.2017.56.01.14 ER -
@article{ author = "Klisić, Aleksandra and Kavarić, Nebojša and Bjelaković, Bojko and Soldatović, Ivan and Martinović, Milica and Kotur-Stevuljević, Jelena", year = "2017", abstract = "Retinol-binding protein 4 (RBP4) is an emerging risk factor for atherosclerotic disease in adults. However, to our knowledge, there are no studies examining the relationship between RBP4 and cardiovascular risk in young population. Therefore, we aimed to estimate this potential relationship in overweight/obese adolescent girls. Seventy overweight/obese adolescent girls, mean age 17.6 +/- 1.20 years, were included. Anthropometric and biochemical parameters were measured. Cardiovascular risk score (CVRS) was calculated by adding points for each risk factor (e.g., sex, high-density lipoprotein cholesterol (HDL-c), non-HDL-c, smoking, blood pressure and fasting glycemia). According to the risk status, we divided adolescent girls into low, medium and high risk groups (-2 lt = CVRS lt = 1, 2 lt = CVRS 54 and CVRS >= 5, respectively). We found significantly higher RBP4 in the high risk group as compared with low risk group (p lt 0.001). However, multiple linear regression analysis showed waist circumference (beta=0.257, p=0.031) to be the only independent predictor of higher cardiovascular risk (adjusted R'=0.342, p lt 0.001). In conclusion, RBP4 may be associated with higher cardiovascular risk in overweight/obese adolescent girls, but this association is mediated by abdominal obesity.", publisher = "Sestre Milosrdnice Univ Hospital, Zagreb", journal = "Acta Clinica Croatica", title = "The association between retinol-binding protein 4 and cardiovascular risk score is mediated by waist circumference in overweight/obese adolescent girls", volume = "56", number = "1", pages = "92-98", doi = "10.20471/acc.2017.56.01.14" }
Klisić, A., Kavarić, N., Bjelaković, B., Soldatović, I., Martinović, M.,& Kotur-Stevuljević, J.. (2017). The association between retinol-binding protein 4 and cardiovascular risk score is mediated by waist circumference in overweight/obese adolescent girls. in Acta Clinica Croatica Sestre Milosrdnice Univ Hospital, Zagreb., 56(1), 92-98. https://doi.org/10.20471/acc.2017.56.01.14
Klisić A, Kavarić N, Bjelaković B, Soldatović I, Martinović M, Kotur-Stevuljević J. The association between retinol-binding protein 4 and cardiovascular risk score is mediated by waist circumference in overweight/obese adolescent girls. in Acta Clinica Croatica. 2017;56(1):92-98. doi:10.20471/acc.2017.56.01.14 .
Klisić, Aleksandra, Kavarić, Nebojša, Bjelaković, Bojko, Soldatović, Ivan, Martinović, Milica, Kotur-Stevuljević, Jelena, "The association between retinol-binding protein 4 and cardiovascular risk score is mediated by waist circumference in overweight/obese adolescent girls" in Acta Clinica Croatica, 56, no. 1 (2017):92-98, https://doi.org/10.20471/acc.2017.56.01.14 . .