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Variations in Chemical Composition, Vasorelaxant and Angiotensin I-Converting Enzyme Inhibitory Activities of Essential Oil from Aerial Parts of Seseli pallasii Besser (Apiaceae)

Authorized Users Only
2017
Authors
Suručić, Relja V.
Kundaković, Tatjana
Lakušić, Branislava
Drakul, Dragana
Milovanović, Slobodan R.
Kovačević, Nada
Article (Published version)
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Abstract
The present paper describes environmental and seasonal-related chemical composition variations, vasorelaxant and angiotensin I-converting enzyme (ACE) activities of essential oil from aerial parts of Seseli pallasii BESSER. The composition was analyzed by GC and GC/MS. Monoterpenes were found to be the most abundant chemical class with alpha-pinene (42.7 - 48.2%) as the most prevalent component. Seseli pallasi essential oil relaxed isolated endothelium-intact mesenteric arteries rings precontracted with phenylephrine with IC50 = 3.10 nl/ml (IC50 = 2.70 mu g/ml). Also, S. pallasii essential oil was found to exhibit a dose-dependent ACE inhibitory activity with an IC50 value of 0.33 mg/ml. In silico evaluation of ACE inhibitory activity of the individual components showed that spathulenol exhibited the best binding affinity with ACE, and the lowest binding energy of -7.5 kcal/mol. The results suggested that combination of vasorelaxing and ACE inhibitory effects of the analyzed S. pallasi...i essential oil might have the potential therapeutic significance in hypertension.

Source:
Chemistry & Biodiversity, 2017, 14, 5
Publisher:
  • Wiley-VCH Verlag GMBH, Weinheim
Projects:
  • Ministry of Science and Technology of Republic of Srpska - 19/6-020/961-110/14

DOI: 10.1002/cbdv.201600407

ISSN: 1612-1872

PubMed: 27943628

WoS: 000401239300004

Scopus: 2-s2.0-85017536066
[ Google Scholar ]
1
1
URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/3027
Collections
  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy
TY  - JOUR
AU  - Suručić, Relja V.
AU  - Kundaković, Tatjana
AU  - Lakušić, Branislava
AU  - Drakul, Dragana
AU  - Milovanović, Slobodan R.
AU  - Kovačević, Nada
PY  - 2017
UR  - http://farfar.pharmacy.bg.ac.rs/handle/123456789/3027
AB  - The present paper describes environmental and seasonal-related chemical composition variations, vasorelaxant and angiotensin I-converting enzyme (ACE) activities of essential oil from aerial parts of Seseli pallasii BESSER. The composition was analyzed by GC and GC/MS. Monoterpenes were found to be the most abundant chemical class with alpha-pinene (42.7 - 48.2%) as the most prevalent component. Seseli pallasi essential oil relaxed isolated endothelium-intact mesenteric arteries rings precontracted with phenylephrine with IC50 = 3.10 nl/ml (IC50 = 2.70 mu g/ml). Also, S. pallasii essential oil was found to exhibit a dose-dependent ACE inhibitory activity with an IC50 value of 0.33 mg/ml. In silico evaluation of ACE inhibitory activity of the individual components showed that spathulenol exhibited the best binding affinity with ACE, and the lowest binding energy of -7.5 kcal/mol. The results suggested that combination of vasorelaxing and ACE inhibitory effects of the analyzed S. pallasii essential oil might have the potential therapeutic significance in hypertension.
PB  - Wiley-VCH Verlag GMBH, Weinheim
T2  - Chemistry & Biodiversity
T1  - Variations in Chemical Composition, Vasorelaxant and Angiotensin I-Converting Enzyme Inhibitory Activities of Essential Oil from Aerial Parts of Seseli pallasii Besser (Apiaceae)
VL  - 14
IS  - 5
DO  - 10.1002/cbdv.201600407
ER  - 
@article{
author = "Suručić, Relja V. and Kundaković, Tatjana and Lakušić, Branislava and Drakul, Dragana and Milovanović, Slobodan R. and Kovačević, Nada",
year = "2017",
url = "http://farfar.pharmacy.bg.ac.rs/handle/123456789/3027",
abstract = "The present paper describes environmental and seasonal-related chemical composition variations, vasorelaxant and angiotensin I-converting enzyme (ACE) activities of essential oil from aerial parts of Seseli pallasii BESSER. The composition was analyzed by GC and GC/MS. Monoterpenes were found to be the most abundant chemical class with alpha-pinene (42.7 - 48.2%) as the most prevalent component. Seseli pallasi essential oil relaxed isolated endothelium-intact mesenteric arteries rings precontracted with phenylephrine with IC50 = 3.10 nl/ml (IC50 = 2.70 mu g/ml). Also, S. pallasii essential oil was found to exhibit a dose-dependent ACE inhibitory activity with an IC50 value of 0.33 mg/ml. In silico evaluation of ACE inhibitory activity of the individual components showed that spathulenol exhibited the best binding affinity with ACE, and the lowest binding energy of -7.5 kcal/mol. The results suggested that combination of vasorelaxing and ACE inhibitory effects of the analyzed S. pallasii essential oil might have the potential therapeutic significance in hypertension.",
publisher = "Wiley-VCH Verlag GMBH, Weinheim",
journal = "Chemistry & Biodiversity",
title = "Variations in Chemical Composition, Vasorelaxant and Angiotensin I-Converting Enzyme Inhibitory Activities of Essential Oil from Aerial Parts of Seseli pallasii Besser (Apiaceae)",
volume = "14",
number = "5",
doi = "10.1002/cbdv.201600407"
}
Suručić RV, Kundaković T, Lakušić B, Drakul D, Milovanović SR, Kovačević N. Variations in Chemical Composition, Vasorelaxant and Angiotensin I-Converting Enzyme Inhibitory Activities of Essential Oil from Aerial Parts of Seseli pallasii Besser (Apiaceae). Chemistry & Biodiversity. 2017;14(5)
Suručić, R. V., Kundaković, T., Lakušić, B., Drakul, D., Milovanović, S. R.,& Kovačević, N. (2017). Variations in Chemical Composition, Vasorelaxant and Angiotensin I-Converting Enzyme Inhibitory Activities of Essential Oil from Aerial Parts of Seseli pallasii Besser (Apiaceae).
Chemistry & BiodiversityWiley-VCH Verlag GMBH, Weinheim., 14(5).
https://doi.org/10.1002/cbdv.201600407
Suručić Relja V., Kundaković Tatjana, Lakušić Branislava, Drakul Dragana, Milovanović Slobodan R., Kovačević Nada, "Variations in Chemical Composition, Vasorelaxant and Angiotensin I-Converting Enzyme Inhibitory Activities of Essential Oil from Aerial Parts of Seseli pallasii Besser (Apiaceae)" 14, no. 5 (2017),
https://doi.org/10.1002/cbdv.201600407 .

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