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dc.creatorSavić, Jelena
dc.creatorMarković, Bojan
dc.creatorVitnik, Vesna
dc.creatorDilber, Sanda
dc.date.accessioned2019-09-02T12:03:05Z
dc.date.available2019-09-02T12:03:05Z
dc.date.issued2018
dc.identifier.issn1450-9636
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/3032
dc.description.abstractpKa values of five β-hydroxy-β-arylalkanoic acids and ibuprofen were determined using the RP-HPLC method. Stationary phase was octadecyl modified (C-18) silica gel, and mobile phase was a mixture of methanol and one of nine different buffers (60:40, v/v). wspH values were measured after mixing methanol with an appropriate buffer. The mean retention time of each compound was plotted against wspH of each mobile phase. The inflection point of each sigmoidal curve represented wspK a of the compound. Using wspK a in already known equations for the specific methanol/buffer mixture, wwpK a values were calculated. Obtained pKa values for synthesized compounds were in a narrow range from 3.34-3.81 and pKa for ibuprofen was 4.45. Predicted pKa values for these compounds in SPARC software showed good correlation with experimental pKa values (R2=0.8048).en
dc.publisherUniverzitet u Kragujevcu - Prirodno-matematički fakultet, Kragujevac
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172041/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceKragujevac Journal of Science
dc.subjectdissociation constanten
dc.subjectanti-inflammatory compoundsen
dc.subjectibuprofenen
dc.subjectliquid chromatographyen
dc.titleDetermination of ionization constants (PKA) of β-hydroxy-β-arylalkanoic acids using high-pressure liquid chromatographyen
dc.typearticle
dc.rights.licenseBY
dcterms.abstractСавић, Јелена; Марковић, Бојан; Дилбер, Санда; Витник, Весна;
dc.citation.issue40
dc.citation.spage103
dc.citation.epage111
dc.citation.other(40): 103-111
dc.citation.rankM51
dc.identifier.doi10.5937/KgJSci1840103S
dc.identifier.fulltexthttps://farfar.pharmacy.bg.ac.rs//bitstream/id/1639/3030.pdf
dc.identifier.rcubconv_1009
dc.type.versionpublishedVersion


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