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Overview of Cadmium Thyroid Disrupting Effects and Mechanisms

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2018
3033.pdf (496.8Kb)
Authors
Buha, Aleksandra
Matović, Vesna
Antonijević, Biljana
Bulat, Zorica
Ćurčić, Marijana
Renieri, Elisavet A.
Tsatsakis, Aristidis
Schweitzer, Amie
Wallace, David
Article (Published version)
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Abstract
Humans are exposed to a significant number of chemicals that are suspected to produce disturbances in hormone homeostasis. Hence, in recent decades, there has been a growing interest in endocrine disruptive chemicals. One of the alleged thyroid disrupting substances is cadmium (Cd), a ubiquitous toxic metal shown to act as a thyroid disruptor and carcinogen in both animals and humans. Multiple PubMed searches with core keywords were performed to identify and evaluate appropriate studies which revealed literature suggesting evidence for the link between exposure to Cd and histological and metabolic changes in the thyroid gland. Furthermore, Cd influence on thyroid homeostasis at the peripheral level has also been hypothesized. Both in vivo and in vitro studies revealed that a Cd exposure at environmentally relevant concentrations results in biphasic Cd dose-thyroid response relationships. Development of thyroid tumors following exposure to Cd has been studied mainly using in vitro metho...dologies. In the thyroid, Cd has been shown to activate or stimulate the activity of various factors, leading to increased cell proliferation and a reduction in normal apoptotic activity. Evidence establishing the association between Cd and thyroid disruption remains ambiguous, with further studies needed to elucidate the issue and improve our understanding of Cd-mediated effects on the thyroid gland.

Keywords:
cadmium / endocrine disruption / thyroid gland / mechanisms
Source:
International Journal of Molecular Sciences, 2018, 19, 5
Publisher:
  • MDPI, Basel
Projects:
  • Improvement and development of hygienic and technological procedures in production of animal originating foodstuffs with the aim of producing high-quality and safe products competetive on the global market (RS-46009)

DOI: 10.3390/ijms19051501

ISSN: 1422-0067

PubMed: 29772829

WoS: 000435297000237

Scopus: 2-s2.0-85047250921
[ Google Scholar ]
60
58
URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/3035
Collections
  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy
TY  - JOUR
AU  - Buha, Aleksandra
AU  - Matović, Vesna
AU  - Antonijević, Biljana
AU  - Bulat, Zorica
AU  - Ćurčić, Marijana
AU  - Renieri, Elisavet A.
AU  - Tsatsakis, Aristidis
AU  - Schweitzer, Amie
AU  - Wallace, David
PY  - 2018
UR  - http://farfar.pharmacy.bg.ac.rs/handle/123456789/3035
AB  - Humans are exposed to a significant number of chemicals that are suspected to produce disturbances in hormone homeostasis. Hence, in recent decades, there has been a growing interest in endocrine disruptive chemicals. One of the alleged thyroid disrupting substances is cadmium (Cd), a ubiquitous toxic metal shown to act as a thyroid disruptor and carcinogen in both animals and humans. Multiple PubMed searches with core keywords were performed to identify and evaluate appropriate studies which revealed literature suggesting evidence for the link between exposure to Cd and histological and metabolic changes in the thyroid gland. Furthermore, Cd influence on thyroid homeostasis at the peripheral level has also been hypothesized. Both in vivo and in vitro studies revealed that a Cd exposure at environmentally relevant concentrations results in biphasic Cd dose-thyroid response relationships. Development of thyroid tumors following exposure to Cd has been studied mainly using in vitro methodologies. In the thyroid, Cd has been shown to activate or stimulate the activity of various factors, leading to increased cell proliferation and a reduction in normal apoptotic activity. Evidence establishing the association between Cd and thyroid disruption remains ambiguous, with further studies needed to elucidate the issue and improve our understanding of Cd-mediated effects on the thyroid gland.
PB  - MDPI, Basel
T2  - International Journal of Molecular Sciences
T1  - Overview of Cadmium Thyroid Disrupting Effects and Mechanisms
VL  - 19
IS  - 5
DO  - 10.3390/ijms19051501
ER  - 
@article{
author = "Buha, Aleksandra and Matović, Vesna and Antonijević, Biljana and Bulat, Zorica and Ćurčić, Marijana and Renieri, Elisavet A. and Tsatsakis, Aristidis and Schweitzer, Amie and Wallace, David",
year = "2018",
url = "http://farfar.pharmacy.bg.ac.rs/handle/123456789/3035",
abstract = "Humans are exposed to a significant number of chemicals that are suspected to produce disturbances in hormone homeostasis. Hence, in recent decades, there has been a growing interest in endocrine disruptive chemicals. One of the alleged thyroid disrupting substances is cadmium (Cd), a ubiquitous toxic metal shown to act as a thyroid disruptor and carcinogen in both animals and humans. Multiple PubMed searches with core keywords were performed to identify and evaluate appropriate studies which revealed literature suggesting evidence for the link between exposure to Cd and histological and metabolic changes in the thyroid gland. Furthermore, Cd influence on thyroid homeostasis at the peripheral level has also been hypothesized. Both in vivo and in vitro studies revealed that a Cd exposure at environmentally relevant concentrations results in biphasic Cd dose-thyroid response relationships. Development of thyroid tumors following exposure to Cd has been studied mainly using in vitro methodologies. In the thyroid, Cd has been shown to activate or stimulate the activity of various factors, leading to increased cell proliferation and a reduction in normal apoptotic activity. Evidence establishing the association between Cd and thyroid disruption remains ambiguous, with further studies needed to elucidate the issue and improve our understanding of Cd-mediated effects on the thyroid gland.",
publisher = "MDPI, Basel",
journal = "International Journal of Molecular Sciences",
title = "Overview of Cadmium Thyroid Disrupting Effects and Mechanisms",
volume = "19",
number = "5",
doi = "10.3390/ijms19051501"
}
Buha A, Matović V, Antonijević B, Bulat Z, Ćurčić M, Renieri EA, Tsatsakis A, Schweitzer A, Wallace D. Overview of Cadmium Thyroid Disrupting Effects and Mechanisms. International Journal of Molecular Sciences. 2018;19(5)
Buha, A., Matović, V., Antonijević, B., Bulat, Z., Ćurčić, M., Renieri, E. A., Tsatsakis, A., Schweitzer, A.,& Wallace, D. (2018). Overview of Cadmium Thyroid Disrupting Effects and Mechanisms.
International Journal of Molecular SciencesMDPI, Basel., 19(5).
https://doi.org/10.3390/ijms19051501
Buha Aleksandra, Matović Vesna, Antonijević Biljana, Bulat Zorica, Ćurčić Marijana, Renieri Elisavet A., Tsatsakis Aristidis, Schweitzer Amie, Wallace David, "Overview of Cadmium Thyroid Disrupting Effects and Mechanisms" 19, no. 5 (2018),
https://doi.org/10.3390/ijms19051501 .

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