Overview of Cadmium Thyroid Disrupting Effects and Mechanisms
![](/themes/MirageFarFaR//images/openAccess.png)
2018
Autori
Buha, Aleksandra![](/themes/MirageFarFaR/images/orcid.png)
Matović, Vesna
![](/themes/MirageFarFaR/images/orcid.png)
Antonijević, Biljana
![](/themes/MirageFarFaR/images/orcid.png)
Bulat, Zorica
![](/themes/MirageFarFaR/images/orcid.png)
Ćurčić, Marijana
![](/themes/MirageFarFaR/images/orcid.png)
Renieri, Elisavet A.
Tsatsakis, Aristidis
![](/themes/MirageFarFaR/images/orcid.png)
Schweitzer, Amie
Wallace, David
![](/themes/MirageFarFaR/images/orcid.png)
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Humans are exposed to a significant number of chemicals that are suspected to produce disturbances in hormone homeostasis. Hence, in recent decades, there has been a growing interest in endocrine disruptive chemicals. One of the alleged thyroid disrupting substances is cadmium (Cd), a ubiquitous toxic metal shown to act as a thyroid disruptor and carcinogen in both animals and humans. Multiple PubMed searches with core keywords were performed to identify and evaluate appropriate studies which revealed literature suggesting evidence for the link between exposure to Cd and histological and metabolic changes in the thyroid gland. Furthermore, Cd influence on thyroid homeostasis at the peripheral level has also been hypothesized. Both in vivo and in vitro studies revealed that a Cd exposure at environmentally relevant concentrations results in biphasic Cd dose-thyroid response relationships. Development of thyroid tumors following exposure to Cd has been studied mainly using in vitro metho...dologies. In the thyroid, Cd has been shown to activate or stimulate the activity of various factors, leading to increased cell proliferation and a reduction in normal apoptotic activity. Evidence establishing the association between Cd and thyroid disruption remains ambiguous, with further studies needed to elucidate the issue and improve our understanding of Cd-mediated effects on the thyroid gland.
Ključne reči:
cadmium / endocrine disruption / thyroid gland / mechanismsIzvor:
International Journal of Molecular Sciences, 2018, 19, 5Izdavač:
- MDPI, Basel
Finansiranje / projekti:
- Unapređenje i razvoj higijenskih i tehnoloških postupaka u proizvodnji namirnica životinjskog porekla u cilju dobijanja kvalitetnih i bezbednih proizvoda konkurentnih na svetskom tržištu (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-46009)
DOI: 10.3390/ijms19051501
ISSN: 1422-0067
PubMed: 29772829
WoS: 000435297000237
Scopus: 2-s2.0-85047250921
Institucija/grupa
PharmacyTY - JOUR AU - Buha, Aleksandra AU - Matović, Vesna AU - Antonijević, Biljana AU - Bulat, Zorica AU - Ćurčić, Marijana AU - Renieri, Elisavet A. AU - Tsatsakis, Aristidis AU - Schweitzer, Amie AU - Wallace, David PY - 2018 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3035 AB - Humans are exposed to a significant number of chemicals that are suspected to produce disturbances in hormone homeostasis. Hence, in recent decades, there has been a growing interest in endocrine disruptive chemicals. One of the alleged thyroid disrupting substances is cadmium (Cd), a ubiquitous toxic metal shown to act as a thyroid disruptor and carcinogen in both animals and humans. Multiple PubMed searches with core keywords were performed to identify and evaluate appropriate studies which revealed literature suggesting evidence for the link between exposure to Cd and histological and metabolic changes in the thyroid gland. Furthermore, Cd influence on thyroid homeostasis at the peripheral level has also been hypothesized. Both in vivo and in vitro studies revealed that a Cd exposure at environmentally relevant concentrations results in biphasic Cd dose-thyroid response relationships. Development of thyroid tumors following exposure to Cd has been studied mainly using in vitro methodologies. In the thyroid, Cd has been shown to activate or stimulate the activity of various factors, leading to increased cell proliferation and a reduction in normal apoptotic activity. Evidence establishing the association between Cd and thyroid disruption remains ambiguous, with further studies needed to elucidate the issue and improve our understanding of Cd-mediated effects on the thyroid gland. PB - MDPI, Basel T2 - International Journal of Molecular Sciences T1 - Overview of Cadmium Thyroid Disrupting Effects and Mechanisms VL - 19 IS - 5 DO - 10.3390/ijms19051501 ER -
@article{ author = "Buha, Aleksandra and Matović, Vesna and Antonijević, Biljana and Bulat, Zorica and Ćurčić, Marijana and Renieri, Elisavet A. and Tsatsakis, Aristidis and Schweitzer, Amie and Wallace, David", year = "2018", abstract = "Humans are exposed to a significant number of chemicals that are suspected to produce disturbances in hormone homeostasis. Hence, in recent decades, there has been a growing interest in endocrine disruptive chemicals. One of the alleged thyroid disrupting substances is cadmium (Cd), a ubiquitous toxic metal shown to act as a thyroid disruptor and carcinogen in both animals and humans. Multiple PubMed searches with core keywords were performed to identify and evaluate appropriate studies which revealed literature suggesting evidence for the link between exposure to Cd and histological and metabolic changes in the thyroid gland. Furthermore, Cd influence on thyroid homeostasis at the peripheral level has also been hypothesized. Both in vivo and in vitro studies revealed that a Cd exposure at environmentally relevant concentrations results in biphasic Cd dose-thyroid response relationships. Development of thyroid tumors following exposure to Cd has been studied mainly using in vitro methodologies. In the thyroid, Cd has been shown to activate or stimulate the activity of various factors, leading to increased cell proliferation and a reduction in normal apoptotic activity. Evidence establishing the association between Cd and thyroid disruption remains ambiguous, with further studies needed to elucidate the issue and improve our understanding of Cd-mediated effects on the thyroid gland.", publisher = "MDPI, Basel", journal = "International Journal of Molecular Sciences", title = "Overview of Cadmium Thyroid Disrupting Effects and Mechanisms", volume = "19", number = "5", doi = "10.3390/ijms19051501" }
Buha, A., Matović, V., Antonijević, B., Bulat, Z., Ćurčić, M., Renieri, E. A., Tsatsakis, A., Schweitzer, A.,& Wallace, D.. (2018). Overview of Cadmium Thyroid Disrupting Effects and Mechanisms. in International Journal of Molecular Sciences MDPI, Basel., 19(5). https://doi.org/10.3390/ijms19051501
Buha A, Matović V, Antonijević B, Bulat Z, Ćurčić M, Renieri EA, Tsatsakis A, Schweitzer A, Wallace D. Overview of Cadmium Thyroid Disrupting Effects and Mechanisms. in International Journal of Molecular Sciences. 2018;19(5). doi:10.3390/ijms19051501 .
Buha, Aleksandra, Matović, Vesna, Antonijević, Biljana, Bulat, Zorica, Ćurčić, Marijana, Renieri, Elisavet A., Tsatsakis, Aristidis, Schweitzer, Amie, Wallace, David, "Overview of Cadmium Thyroid Disrupting Effects and Mechanisms" in International Journal of Molecular Sciences, 19, no. 5 (2018), https://doi.org/10.3390/ijms19051501 . .