Приказ основних података о документу

dc.creatorBuha, Aleksandra
dc.creatorMatović, Vesna
dc.creatorAntonijević, Biljana
dc.creatorBulat, Zorica
dc.creatorĆurčić, Marijana
dc.creatorRenieri, Elisavet A.
dc.creatorTsatsakis, Aristidis
dc.creatorSchweitzer, Amie
dc.creatorWallace, David
dc.date.accessioned2019-09-02T12:03:11Z
dc.date.available2019-09-02T12:03:11Z
dc.date.issued2018
dc.identifier.issn1422-0067
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/3035
dc.description.abstractHumans are exposed to a significant number of chemicals that are suspected to produce disturbances in hormone homeostasis. Hence, in recent decades, there has been a growing interest in endocrine disruptive chemicals. One of the alleged thyroid disrupting substances is cadmium (Cd), a ubiquitous toxic metal shown to act as a thyroid disruptor and carcinogen in both animals and humans. Multiple PubMed searches with core keywords were performed to identify and evaluate appropriate studies which revealed literature suggesting evidence for the link between exposure to Cd and histological and metabolic changes in the thyroid gland. Furthermore, Cd influence on thyroid homeostasis at the peripheral level has also been hypothesized. Both in vivo and in vitro studies revealed that a Cd exposure at environmentally relevant concentrations results in biphasic Cd dose-thyroid response relationships. Development of thyroid tumors following exposure to Cd has been studied mainly using in vitro methodologies. In the thyroid, Cd has been shown to activate or stimulate the activity of various factors, leading to increased cell proliferation and a reduction in normal apoptotic activity. Evidence establishing the association between Cd and thyroid disruption remains ambiguous, with further studies needed to elucidate the issue and improve our understanding of Cd-mediated effects on the thyroid gland.en
dc.publisherMDPI, Basel
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46009/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceInternational Journal of Molecular Sciences
dc.subjectcadmiumen
dc.subjectendocrine disruptionen
dc.subjectthyroid glanden
dc.subjectmechanismsen
dc.titleOverview of Cadmium Thyroid Disrupting Effects and Mechanismsen
dc.typearticle
dc.rights.licenseBY
dcterms.abstractМатовић, Весна; Тсатсакис, Aристидис; Булат, Зорица; Ћурчић, Маријана; Рениери, Елисавет A.; Сцхwеитзер, Aмие; Буха, Aлександра; Aнтонијевић, Биљана; Wаллаце, Давид;
dc.citation.volume19
dc.citation.issue5
dc.citation.other19(5): -
dc.citation.rankM21
dc.identifier.wos000435297000237
dc.identifier.doi10.3390/ijms19051501
dc.identifier.pmid29772829
dc.identifier.scopus2-s2.0-85047250921
dc.identifier.fulltexthttps://farfar.pharmacy.bg.ac.rs//bitstream/id/1642/3033.pdf
dc.type.versionpublishedVersion


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Приказ основних података о документу