Synthesis of 2-unsubstituted imidazolones from bisamides via a one-pot, domino dehydration/base promoted cyclisation process
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A one-pot, domino process was developed as an alternative approach for the preparation of 2-unsubstituted imidazolones. The methodology utilizes readily accessible bisamides, which upon a dehydration/-cyclisation sequence produced imidazolones in good yields. The transformation relies on the compatibility of the dehydrating agent and base, and the reaction conditions tolerate various functional groups.
Keywords:Imidazolones / Bisamides / One-pot cyclisation
Source:Tetrahedron-Asymmetry, 2018, 59, 10, 914-917
- Pergamon-Elsevier Science Ltd, Oxford