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The association between follicle stimulating hormone and glutathione peroxidase activity is dependent on abdominal obesity in postmenopausal women

Authorized Users Only
2018
Authors
Klisić, Aleksandra
Kotur-Stevuljević, Jelena
Kavarić, Nebojša
Martinović, Milica
Matić, Marija
Article (Published version)
Metadata
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Abstract
Purpose Menopause is frequently associated with an increase in visceral fat, thus modifying redox status by promoting oxidative damage and decreasing antioxidant defense systems. It is known that at higher concentrations estradiol has some antioxidant properties, while its decline in postmenopause is associated with pro-oxidant effects. However, the role of follicle stimulating hormone (FSH) in antioxidant defense in postmenopausal women is still not well elucidated. Therefore, we aimed to evaluate the potential complex association between visceral obesity, FSH and enzymatic antioxidant defense as measured by glutathione peroxidase (GPx) in postmenopausal women. Methods A total of 150 postmenopausal women (mean age 56.6 +/- 4.8 years), among them 50 normal weight and 100 overweight/obese, were included. GPx activity, FSH, luteinizing hormone, estradiol, total testosterone, cardiometabolic and anthropometric parameters, were determined. Results With increasing tertiles of serum FSH leve...ls, significant increase in GPx activity (P = 0.005) was found. Also, the highest number of overweight/obese subjects were in the group with the lowest FSH values (chi(2) = 14.9, P lt 0.001). After multiple linear regression analysis, the relationship between GPx and FSH disappeared, whereas only higher waist circumference (beta = -0.218, P = 0.045) predicted lower FSH level (adjusted R-2 = 0.227). Conclusion Higher GPx activity is associated with higher FSH level, but abdominal obesity may be the underlying determinant of this relationship.

Keywords:
Antioxidant defense / Follicle stimulating hormone / Obesity / Postmenopausal women
Source:
Eating and Weight Disorders, 2018, 23, 1, 133-141
Publisher:
  • Springer, New York
Funding / projects:
  • Interactive role of dyslipidemia, oxidative stress and inflammation in atherosclerosis and other diseases: genetic and biochemical markers (RS-175035)

DOI: 10.1007/s40519-016-0325-1

ISSN: 1124-4909

PubMed: 27663696

WoS: 000424649500015

Scopus: 2-s2.0-85047532417
[ Google Scholar ]
15
13
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/3039
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Klisić, Aleksandra
AU  - Kotur-Stevuljević, Jelena
AU  - Kavarić, Nebojša
AU  - Martinović, Milica
AU  - Matić, Marija
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3039
AB  - Purpose Menopause is frequently associated with an increase in visceral fat, thus modifying redox status by promoting oxidative damage and decreasing antioxidant defense systems. It is known that at higher concentrations estradiol has some antioxidant properties, while its decline in postmenopause is associated with pro-oxidant effects. However, the role of follicle stimulating hormone (FSH) in antioxidant defense in postmenopausal women is still not well elucidated. Therefore, we aimed to evaluate the potential complex association between visceral obesity, FSH and enzymatic antioxidant defense as measured by glutathione peroxidase (GPx) in postmenopausal women. Methods A total of 150 postmenopausal women (mean age 56.6 +/- 4.8 years), among them 50 normal weight and 100 overweight/obese, were included. GPx activity, FSH, luteinizing hormone, estradiol, total testosterone, cardiometabolic and anthropometric parameters, were determined. Results With increasing tertiles of serum FSH levels, significant increase in GPx activity (P = 0.005) was found. Also, the highest number of overweight/obese subjects were in the group with the lowest FSH values (chi(2) = 14.9, P  lt  0.001). After multiple linear regression analysis, the relationship between GPx and FSH disappeared, whereas only higher waist circumference (beta = -0.218, P = 0.045) predicted lower FSH level (adjusted R-2 = 0.227). Conclusion Higher GPx activity is associated with higher FSH level, but abdominal obesity may be the underlying determinant of this relationship.
PB  - Springer, New York
T2  - Eating and Weight Disorders
T1  - The association between follicle stimulating hormone and glutathione peroxidase activity is dependent on abdominal obesity in postmenopausal women
VL  - 23
IS  - 1
SP  - 133
EP  - 141
DO  - 10.1007/s40519-016-0325-1
ER  - 
@article{
author = "Klisić, Aleksandra and Kotur-Stevuljević, Jelena and Kavarić, Nebojša and Martinović, Milica and Matić, Marija",
year = "2018",
abstract = "Purpose Menopause is frequently associated with an increase in visceral fat, thus modifying redox status by promoting oxidative damage and decreasing antioxidant defense systems. It is known that at higher concentrations estradiol has some antioxidant properties, while its decline in postmenopause is associated with pro-oxidant effects. However, the role of follicle stimulating hormone (FSH) in antioxidant defense in postmenopausal women is still not well elucidated. Therefore, we aimed to evaluate the potential complex association between visceral obesity, FSH and enzymatic antioxidant defense as measured by glutathione peroxidase (GPx) in postmenopausal women. Methods A total of 150 postmenopausal women (mean age 56.6 +/- 4.8 years), among them 50 normal weight and 100 overweight/obese, were included. GPx activity, FSH, luteinizing hormone, estradiol, total testosterone, cardiometabolic and anthropometric parameters, were determined. Results With increasing tertiles of serum FSH levels, significant increase in GPx activity (P = 0.005) was found. Also, the highest number of overweight/obese subjects were in the group with the lowest FSH values (chi(2) = 14.9, P  lt  0.001). After multiple linear regression analysis, the relationship between GPx and FSH disappeared, whereas only higher waist circumference (beta = -0.218, P = 0.045) predicted lower FSH level (adjusted R-2 = 0.227). Conclusion Higher GPx activity is associated with higher FSH level, but abdominal obesity may be the underlying determinant of this relationship.",
publisher = "Springer, New York",
journal = "Eating and Weight Disorders",
title = "The association between follicle stimulating hormone and glutathione peroxidase activity is dependent on abdominal obesity in postmenopausal women",
volume = "23",
number = "1",
pages = "133-141",
doi = "10.1007/s40519-016-0325-1"
}
Klisić, A., Kotur-Stevuljević, J., Kavarić, N., Martinović, M.,& Matić, M.. (2018). The association between follicle stimulating hormone and glutathione peroxidase activity is dependent on abdominal obesity in postmenopausal women. in Eating and Weight Disorders
Springer, New York., 23(1), 133-141.
https://doi.org/10.1007/s40519-016-0325-1
Klisić A, Kotur-Stevuljević J, Kavarić N, Martinović M, Matić M. The association between follicle stimulating hormone and glutathione peroxidase activity is dependent on abdominal obesity in postmenopausal women. in Eating and Weight Disorders. 2018;23(1):133-141.
doi:10.1007/s40519-016-0325-1 .
Klisić, Aleksandra, Kotur-Stevuljević, Jelena, Kavarić, Nebojša, Martinović, Milica, Matić, Marija, "The association between follicle stimulating hormone and glutathione peroxidase activity is dependent on abdominal obesity in postmenopausal women" in Eating and Weight Disorders, 23, no. 1 (2018):133-141,
https://doi.org/10.1007/s40519-016-0325-1 . .

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