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Influence of pH and agitation intensity on drug dissolution from tablets evaluated by means of factorial design

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Authors
Parojčić, Jelena
Đurić, Zorica
Jovanović, M
Ibrić, Svetlana
Nikolić, L
Article (Published version)
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Abstract
Dissolution rate of a drug substance can be strongly influenced by the experimental conditions employed, among which agitation intensity and pH value were recognized as the most important. A complete two-factor, three-level factorial design followed by multiple regression analysis was applied in order to investigate the influence of pH and agitation intensity on paracetamol (CAS 103-90-2) and acetylsalicylic acid (CAS 50-78-2) dissolution from conventional tablets. Mean dissolution time, amount of drug dissolved after 30 min and first-order dissolution rate constant were evaluated as response variables in terms of their applicability to characterize different release profiles. The obtained results indicated that factorially designed experiments present a valuable tool in dissolution method development. Mean dissolution time showed to be the most useful response criterion capable to differentiate between dissolution curves of different shape.
Keywords:
Acetylsalicylic acid / CAS 103-90-2 / CAS 50-78-2 / Dissolution testing / Paracetamol / Tablets / experimental design / factorial design
Source:
Drugs Made in Germany, 2001, 44, 1, 19-24
Publisher:
  • Editio Cantor Verlag GmbH

ISSN: 0012-6683

Scopus: 2-s2.0-0035075857
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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/304
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  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy

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