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Influence of pH and agitation intensity on drug dissolution from tablets evaluated by means of factorial design

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Authors
Parojčić, Jelena
Đurić, Zorica
Jovanović, M
Ibrić, Svetlana
Nikolić, L
Article (Published version)
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Abstract
Dissolution rate of a drug substance can be strongly influenced by the experimental conditions employed, among which agitation intensity and pH value were recognized as the most important. A complete two-factor, three-level factorial design followed by multiple regression analysis was applied in order to investigate the influence of pH and agitation intensity on paracetamol (CAS 103-90-2) and acetylsalicylic acid (CAS 50-78-2) dissolution from conventional tablets. Mean dissolution time, amount of drug dissolved after 30 min and first-order dissolution rate constant were evaluated as response variables in terms of their applicability to characterize different release profiles. The obtained results indicated that factorially designed experiments present a valuable tool in dissolution method development. Mean dissolution time showed to be the most useful response criterion capable to differentiate between dissolution curves of different shape.
Keywords:
Acetylsalicylic acid / CAS 103-90-2 / CAS 50-78-2 / Dissolution testing / Paracetamol / Tablets / experimental design / factorial design
Source:
Drugs Made in Germany, 2001, 44, 1, 19-24
Publisher:
  • Editio Cantor Verlag GmbH

ISSN: 0012-6683

Scopus: 2-s2.0-0035075857
[ Google Scholar ]
Handle
https://hdl.handle.net/21.15107/rcub_farfar_304
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/304
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Parojčić, Jelena
AU  - Đurić, Zorica
AU  - Jovanović, M
AU  - Ibrić, Svetlana
AU  - Nikolić, L
PY  - 2001
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/304
AB  - Dissolution rate of a drug substance can be strongly influenced by the experimental conditions employed, among which agitation intensity and pH value were recognized as the most important. A complete two-factor, three-level factorial design followed by multiple regression analysis was applied in order to investigate the influence of pH and agitation intensity on paracetamol (CAS 103-90-2) and acetylsalicylic acid (CAS 50-78-2) dissolution from conventional tablets. Mean dissolution time, amount of drug dissolved after 30 min and first-order dissolution rate constant were evaluated as response variables in terms of their applicability to characterize different release profiles. The obtained results indicated that factorially designed experiments present a valuable tool in dissolution method development. Mean dissolution time showed to be the most useful response criterion capable to differentiate between dissolution curves of different shape.
PB  - Editio Cantor Verlag GmbH
T2  - Drugs Made in Germany
T1  - Influence of pH and agitation intensity on drug dissolution from tablets evaluated by means of factorial design
VL  - 44
IS  - 1
SP  - 19
EP  - 24
UR  - https://hdl.handle.net/21.15107/rcub_farfar_304
ER  - 
@article{
author = "Parojčić, Jelena and Đurić, Zorica and Jovanović, M and Ibrić, Svetlana and Nikolić, L",
year = "2001",
abstract = "Dissolution rate of a drug substance can be strongly influenced by the experimental conditions employed, among which agitation intensity and pH value were recognized as the most important. A complete two-factor, three-level factorial design followed by multiple regression analysis was applied in order to investigate the influence of pH and agitation intensity on paracetamol (CAS 103-90-2) and acetylsalicylic acid (CAS 50-78-2) dissolution from conventional tablets. Mean dissolution time, amount of drug dissolved after 30 min and first-order dissolution rate constant were evaluated as response variables in terms of their applicability to characterize different release profiles. The obtained results indicated that factorially designed experiments present a valuable tool in dissolution method development. Mean dissolution time showed to be the most useful response criterion capable to differentiate between dissolution curves of different shape.",
publisher = "Editio Cantor Verlag GmbH",
journal = "Drugs Made in Germany",
title = "Influence of pH and agitation intensity on drug dissolution from tablets evaluated by means of factorial design",
volume = "44",
number = "1",
pages = "19-24",
url = "https://hdl.handle.net/21.15107/rcub_farfar_304"
}
Parojčić, J., Đurić, Z., Jovanović, M., Ibrić, S.,& Nikolić, L.. (2001). Influence of pH and agitation intensity on drug dissolution from tablets evaluated by means of factorial design. in Drugs Made in Germany
Editio Cantor Verlag GmbH., 44(1), 19-24.
https://hdl.handle.net/21.15107/rcub_farfar_304
Parojčić J, Đurić Z, Jovanović M, Ibrić S, Nikolić L. Influence of pH and agitation intensity on drug dissolution from tablets evaluated by means of factorial design. in Drugs Made in Germany. 2001;44(1):19-24.
https://hdl.handle.net/21.15107/rcub_farfar_304 .
Parojčić, Jelena, Đurić, Zorica, Jovanović, M, Ibrić, Svetlana, Nikolić, L, "Influence of pH and agitation intensity on drug dissolution from tablets evaluated by means of factorial design" in Drugs Made in Germany, 44, no. 1 (2001):19-24,
https://hdl.handle.net/21.15107/rcub_farfar_304 .

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