Preparation of pyrrolizinone derivatives via sequential transformations of cyclic allyl imides: synthesis of quinolactacide and marinamide
Authorized Users Only
Article (Published version)
MetadataShow full item record
A facile synthetic route has been developed for the preparation of pyrrolizinone derivatives employing N-allyl imides as starting materials. The nucleophilic addition of a vinyl Grignard reagent/RCM/elimination sequence afforded pyrrolizinones in good yields and has been applied for the preparation of naturally occurring quinolactacide and marinamide.
Source:Organic & Biomolecular Chemistry, 2018, 16, 12, 2125-2133
- Royal Soc Chemistry, Cambridge