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dc.creatorKasagić-Vujanović, Irena
dc.creatorJančić-Stojanović, Biljana
dc.creatorIvanović, Darko
dc.date.accessioned2019-09-02T12:03:19Z
dc.date.available2019-09-02T12:03:19Z
dc.date.issued2018
dc.identifier.issn1082-6076
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/3041
dc.description.abstractUsing theoretical models, retention mechanisms of amlodipine besilate and its impurities D, E, and F were tested, as well as bisoprolol fumarate and its impurities A, C, K, and L. Appropriate theoretical retention models for tested compounds were used, which enabled the determination of retention mechanisms responsible for the separation of tested compounds on three different HILIC column: silica, amino, and diol. In order to describe the effect of ratio of aqueous and organic portion of the mobile phase on the retention behavior of tested compounds, as well as the consideration of shares of partition and adsorption processes in HILIC retention mechanism in all three columns, partitioning and adsorption retention theoretical models were calculated. For this purpose, the water content was varied in the range from 4% to 29%, corresponding to the HILIC region of mobile phase composition. During the experiment, values of other factors of mobile phase were maintained at a constant level. Regression coefficients of partition and adsorption retention models and the corresponding determination coefficients were determined (R-2). Partitioning models for all tested compounds on amino column had higher R-2 values, while adsorption models for all compounds tested on silica and diol column had higher R-2 value. [GRAPHICS] .en
dc.publisherTaylor & Francis Inc, Philadelphia
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172052/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Liquid Chromatography & Related Technologies
dc.subjectAdsorption modelen
dc.subjectamlodipineen
dc.subjectbisoprololen
dc.subjectHILICen
dc.subjectpartitioning modelen
dc.subjectretention mechanismsen
dc.titleInvestigation of the retention mechanisms of amlodipine besylate, bisoprolol fumarate, and their impurities on three different HILIC columnsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractКасагић-Вујановић, Ирена; Ивановић, Дарко; Јанчић-Стојановић, Биљана;
dc.citation.volume41
dc.citation.issue9
dc.citation.spage523
dc.citation.epage531
dc.citation.other41(9): 523-531
dc.citation.rankM23
dc.identifier.wos000448729100008
dc.identifier.doi10.1080/10826076.2018.1476380
dc.identifier.scopus2-s2.0-85055431229
dc.type.versionpublishedVersion


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