Analytical Approaches to the Characterization of Solid Drug Delivery Systems with Porous Adsorbent Carriers
Само за регистроване кориснике
2018
Чланак у часопису (Објављена верзија)

Метаподаци
Приказ свих података о документуАпстракт
A large variety of analytical techniques are available to meet the needs of characterization of solid samples. But, when solid drug delivery systems are concerned we are faced with demanding methodologies which have to compile capabilities of analytical techniques in regard to large diversity of structures and surface functionality of analyzed adsorbent carriers. In this review, the most commonly used analytical techniques are presented with their basic principles, advantages and disadvantages in applications of interest. Adsorbent carriers are widely used today as ingredients in the formulation of pharmaceutical forms, for increasing the dissolution rate of the drug and hence the bioavailability. They are also used in the formulation of substances with modified or target drug release into a specific tissue. Methods of thermal analysis (Thermogravimetry - TGA, Differential Scanning Calorimetry - DSC and Thermal microscopy - TM), spectroscopic methods (Infrared Spectroscopy - IR, especi...ally Fourier Transform Infrared Spectroscopy - FTIR and Raman spectroscopy), crystallographic methods (Powder X-Ray Diffraction - PXRD) and finally Scanning Electron Microscopy (SEM) are the most powerful in the characterization of modern therapeutic systems with porous adsorbents. The problem-solving power of each particular analytical method is often enhanced by using simultaneous methods rather than a single technique.
Кључне речи:
Thermal analysis / TA / Infrared Spectroscopy / IR / Fourier Transform Infrared Spectroscopy / FTIR / Raman spectroscopy / Powder X-Ray Diffraction / PXRD / Scanning Electron Microscopy (SEM) and drug dissolutionИзвор:
Current Medicinal Chemistry, 2018, 25, 33, 3956-3972Издавач:
- Bentham Science Publ Ltd, Sharjah
Финансирање / пројекти:
DOI: 10.2174/0929867325666180212120908
ISSN: 0929-8673
PubMed: 29436989
WoS: 000448120700002
Scopus: 2-s2.0-85055634182
Институција/група
PharmacyTY - JOUR AU - Krstić, Marko AU - Ražić, Slavica PY - 2018 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3046 AB - A large variety of analytical techniques are available to meet the needs of characterization of solid samples. But, when solid drug delivery systems are concerned we are faced with demanding methodologies which have to compile capabilities of analytical techniques in regard to large diversity of structures and surface functionality of analyzed adsorbent carriers. In this review, the most commonly used analytical techniques are presented with their basic principles, advantages and disadvantages in applications of interest. Adsorbent carriers are widely used today as ingredients in the formulation of pharmaceutical forms, for increasing the dissolution rate of the drug and hence the bioavailability. They are also used in the formulation of substances with modified or target drug release into a specific tissue. Methods of thermal analysis (Thermogravimetry - TGA, Differential Scanning Calorimetry - DSC and Thermal microscopy - TM), spectroscopic methods (Infrared Spectroscopy - IR, especially Fourier Transform Infrared Spectroscopy - FTIR and Raman spectroscopy), crystallographic methods (Powder X-Ray Diffraction - PXRD) and finally Scanning Electron Microscopy (SEM) are the most powerful in the characterization of modern therapeutic systems with porous adsorbents. The problem-solving power of each particular analytical method is often enhanced by using simultaneous methods rather than a single technique. PB - Bentham Science Publ Ltd, Sharjah T2 - Current Medicinal Chemistry T1 - Analytical Approaches to the Characterization of Solid Drug Delivery Systems with Porous Adsorbent Carriers VL - 25 IS - 33 SP - 3956 EP - 3972 DO - 10.2174/0929867325666180212120908 ER -
@article{ author = "Krstić, Marko and Ražić, Slavica", year = "2018", abstract = "A large variety of analytical techniques are available to meet the needs of characterization of solid samples. But, when solid drug delivery systems are concerned we are faced with demanding methodologies which have to compile capabilities of analytical techniques in regard to large diversity of structures and surface functionality of analyzed adsorbent carriers. In this review, the most commonly used analytical techniques are presented with their basic principles, advantages and disadvantages in applications of interest. Adsorbent carriers are widely used today as ingredients in the formulation of pharmaceutical forms, for increasing the dissolution rate of the drug and hence the bioavailability. They are also used in the formulation of substances with modified or target drug release into a specific tissue. Methods of thermal analysis (Thermogravimetry - TGA, Differential Scanning Calorimetry - DSC and Thermal microscopy - TM), spectroscopic methods (Infrared Spectroscopy - IR, especially Fourier Transform Infrared Spectroscopy - FTIR and Raman spectroscopy), crystallographic methods (Powder X-Ray Diffraction - PXRD) and finally Scanning Electron Microscopy (SEM) are the most powerful in the characterization of modern therapeutic systems with porous adsorbents. The problem-solving power of each particular analytical method is often enhanced by using simultaneous methods rather than a single technique.", publisher = "Bentham Science Publ Ltd, Sharjah", journal = "Current Medicinal Chemistry", title = "Analytical Approaches to the Characterization of Solid Drug Delivery Systems with Porous Adsorbent Carriers", volume = "25", number = "33", pages = "3956-3972", doi = "10.2174/0929867325666180212120908" }
Krstić, M.,& Ražić, S.. (2018). Analytical Approaches to the Characterization of Solid Drug Delivery Systems with Porous Adsorbent Carriers. in Current Medicinal Chemistry Bentham Science Publ Ltd, Sharjah., 25(33), 3956-3972. https://doi.org/10.2174/0929867325666180212120908
Krstić M, Ražić S. Analytical Approaches to the Characterization of Solid Drug Delivery Systems with Porous Adsorbent Carriers. in Current Medicinal Chemistry. 2018;25(33):3956-3972. doi:10.2174/0929867325666180212120908 .
Krstić, Marko, Ražić, Slavica, "Analytical Approaches to the Characterization of Solid Drug Delivery Systems with Porous Adsorbent Carriers" in Current Medicinal Chemistry, 25, no. 33 (2018):3956-3972, https://doi.org/10.2174/0929867325666180212120908 . .