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Analytical Approaches to the Characterization of Solid Drug Delivery Systems with Porous Adsorbent Carriers

Samo za registrovane korisnike
2018
Autori
Krstić, Marko
Ražić, Slavica
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentu
Apstrakt
A large variety of analytical techniques are available to meet the needs of characterization of solid samples. But, when solid drug delivery systems are concerned we are faced with demanding methodologies which have to compile capabilities of analytical techniques in regard to large diversity of structures and surface functionality of analyzed adsorbent carriers. In this review, the most commonly used analytical techniques are presented with their basic principles, advantages and disadvantages in applications of interest. Adsorbent carriers are widely used today as ingredients in the formulation of pharmaceutical forms, for increasing the dissolution rate of the drug and hence the bioavailability. They are also used in the formulation of substances with modified or target drug release into a specific tissue. Methods of thermal analysis (Thermogravimetry - TGA, Differential Scanning Calorimetry - DSC and Thermal microscopy - TM), spectroscopic methods (Infrared Spectroscopy - IR, especi...ally Fourier Transform Infrared Spectroscopy - FTIR and Raman spectroscopy), crystallographic methods (Powder X-Ray Diffraction - PXRD) and finally Scanning Electron Microscopy (SEM) are the most powerful in the characterization of modern therapeutic systems with porous adsorbents. The problem-solving power of each particular analytical method is often enhanced by using simultaneous methods rather than a single technique.

Ključne reči:
Thermal analysis / TA / Infrared Spectroscopy / IR / Fourier Transform Infrared Spectroscopy / FTIR / Raman spectroscopy / Powder X-Ray Diffraction / PXRD / Scanning Electron Microscopy (SEM) and drug dissolution
Izvor:
Current Medicinal Chemistry, 2018, 25, 33, 3956-3972
Izdavač:
  • Bentham Science Publ Ltd, Sharjah
Finansiranje / projekti:
  • Razvoj proizvoda i tehnologija koje obezbeđuju željeno oslobađanje lekovitih supstanci iz čvrstih farmaceutskih oblika (RS-34007)

DOI: 10.2174/0929867325666180212120908

ISSN: 0929-8673

PubMed: 29436989

WoS: 000448120700002

Scopus: 2-s2.0-85055634182
[ Google Scholar ]
1
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/3046
Kolekcije
  • Radovi istraživača / Researchers’ publications
Institucija/grupa
Pharmacy
TY  - JOUR
AU  - Krstić, Marko
AU  - Ražić, Slavica
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3046
AB  - A large variety of analytical techniques are available to meet the needs of characterization of solid samples. But, when solid drug delivery systems are concerned we are faced with demanding methodologies which have to compile capabilities of analytical techniques in regard to large diversity of structures and surface functionality of analyzed adsorbent carriers. In this review, the most commonly used analytical techniques are presented with their basic principles, advantages and disadvantages in applications of interest. Adsorbent carriers are widely used today as ingredients in the formulation of pharmaceutical forms, for increasing the dissolution rate of the drug and hence the bioavailability. They are also used in the formulation of substances with modified or target drug release into a specific tissue. Methods of thermal analysis (Thermogravimetry - TGA, Differential Scanning Calorimetry - DSC and Thermal microscopy - TM), spectroscopic methods (Infrared Spectroscopy - IR, especially Fourier Transform Infrared Spectroscopy - FTIR and Raman spectroscopy), crystallographic methods (Powder X-Ray Diffraction - PXRD) and finally Scanning Electron Microscopy (SEM) are the most powerful in the characterization of modern therapeutic systems with porous adsorbents. The problem-solving power of each particular analytical method is often enhanced by using simultaneous methods rather than a single technique.
PB  - Bentham Science Publ Ltd, Sharjah
T2  - Current Medicinal Chemistry
T1  - Analytical Approaches to the Characterization of Solid Drug Delivery Systems with Porous Adsorbent Carriers
VL  - 25
IS  - 33
SP  - 3956
EP  - 3972
DO  - 10.2174/0929867325666180212120908
ER  - 
@article{
author = "Krstić, Marko and Ražić, Slavica",
year = "2018",
abstract = "A large variety of analytical techniques are available to meet the needs of characterization of solid samples. But, when solid drug delivery systems are concerned we are faced with demanding methodologies which have to compile capabilities of analytical techniques in regard to large diversity of structures and surface functionality of analyzed adsorbent carriers. In this review, the most commonly used analytical techniques are presented with their basic principles, advantages and disadvantages in applications of interest. Adsorbent carriers are widely used today as ingredients in the formulation of pharmaceutical forms, for increasing the dissolution rate of the drug and hence the bioavailability. They are also used in the formulation of substances with modified or target drug release into a specific tissue. Methods of thermal analysis (Thermogravimetry - TGA, Differential Scanning Calorimetry - DSC and Thermal microscopy - TM), spectroscopic methods (Infrared Spectroscopy - IR, especially Fourier Transform Infrared Spectroscopy - FTIR and Raman spectroscopy), crystallographic methods (Powder X-Ray Diffraction - PXRD) and finally Scanning Electron Microscopy (SEM) are the most powerful in the characterization of modern therapeutic systems with porous adsorbents. The problem-solving power of each particular analytical method is often enhanced by using simultaneous methods rather than a single technique.",
publisher = "Bentham Science Publ Ltd, Sharjah",
journal = "Current Medicinal Chemistry",
title = "Analytical Approaches to the Characterization of Solid Drug Delivery Systems with Porous Adsorbent Carriers",
volume = "25",
number = "33",
pages = "3956-3972",
doi = "10.2174/0929867325666180212120908"
}
Krstić, M.,& Ražić, S.. (2018). Analytical Approaches to the Characterization of Solid Drug Delivery Systems with Porous Adsorbent Carriers. in Current Medicinal Chemistry
Bentham Science Publ Ltd, Sharjah., 25(33), 3956-3972.
https://doi.org/10.2174/0929867325666180212120908
Krstić M, Ražić S. Analytical Approaches to the Characterization of Solid Drug Delivery Systems with Porous Adsorbent Carriers. in Current Medicinal Chemistry. 2018;25(33):3956-3972.
doi:10.2174/0929867325666180212120908 .
Krstić, Marko, Ražić, Slavica, "Analytical Approaches to the Characterization of Solid Drug Delivery Systems with Porous Adsorbent Carriers" in Current Medicinal Chemistry, 25, no. 33 (2018):3956-3972,
https://doi.org/10.2174/0929867325666180212120908 . .

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