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Significance of LDL and HDL subclasses characterization in the assessment of risk for colorectal cancer development

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2018
3046.pdf (164.4Kb)
Authors
Stevanović, Milica
Vekić, Jelena
Bogavac-Stanojević, Nataša
Janać, Jelena
Stjepanović, Željka
Zeljković, Dejan
Trifunović, Bratislav
Spasojević-Kalimanovska, Vesna
Zeljković, Aleksandra
Article (Published version)
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Abstract
Introduction: Dyslipidaemia contributes to the occurrence of colorectal cancer (CRC). We hypothesized that qualitative changes of lipoproteins are associated with the risk for CRC development. This study analyses low-density lipoprotein (LDL) and high-density lipoprotein (HDL) diameters, as well as distribution of LDL and HDL subclasses in patients with CRC, with an aim to determine whether advanced lipid testing might be useful in predicting the risk for the onset of this malignancy. Materials and methods: This case-control study included 84 patients with newly diagnosed CRC and 92 controls. Gradient gel electrophoresis was applied for separation of lipoprotein subclasses and for LDL and HDL diameters determination. Lipid parameters were measured using routine enzymatic methods. Results: Total cholesterol, HDL and LDL-cholesterol were significantly lower in CRC patients compared to controls (4.47 mmol/L vs. 5.63 mmol/L; 0.99 mmol/L vs. 1.27 mmol/L; 2.90 mmol/L vs. 3.66 mmol/L; P lt ...0.001, respectively). Patients had significantly smaller LDL (25.14 nm vs. 26.92 nm; P lt 0.001) and HDL diameters (8.76 nm vs. 10.17 nm; P lt 0.001) and greater proportion of small, dense LDL particles (54.0% vs. 52.9%; P = 0.044) than controls. Decreased LDL and HDL diameters were independent predictors of CRC (OR = 0.5, P = 0.001 and OR = 0.5, P = 0.008, respectively), and alongside with age and HDL-cholesterol concentrations formed the optimal cost-effective model, providing adequate discriminative abilities for CRC (AUC = 0.89) and correct patients classification (81%). Conclusions: Patients with CRC have decreased LDL and HDL diameters and increased proportion of smaller particles. LDL and HDL diameters determination could be useful in assessing the risk for CRC development.

Keywords:
colorectal cancer / risk prediction / lipoprotein subclasses / lipoprotein size / cost-effectiveness
Source:
Biochemia Medica, 2018, 28, 3
Publisher:
  • Croatian Soc Medical Biochemists, Zagreb
Projects:
  • Interactive role of dyslipidemia, oxidative stress and inflammation in atherosclerosis and other diseases: genetic and biochemical markers (RS-175035)

DOI: 10.11613/BM.2018.030713

ISSN: 1330-0962

PubMed: 30429670

WoS: 000448275400016

Scopus: 2-s2.0-85055571303
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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/3048
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  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy

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