Significance of LDL and HDL subclasses characterization in the assessment of risk for colorectal cancer development

2018
Authors
Stevanović, MilicaVekić, Jelena

Bogavac-Stanojević, Nataša

Janać, Jelena

Stjepanović, Željka
Zeljković, Dejan
Trifunović, Bratislav
Spasojević-Kalimanovska, Vesna

Zeljković, Aleksandra

Article (Published version)

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Introduction: Dyslipidaemia contributes to the occurrence of colorectal cancer (CRC). We hypothesized that qualitative changes of lipoproteins are associated with the risk for CRC development. This study analyses low-density lipoprotein (LDL) and high-density lipoprotein (HDL) diameters, as well as distribution of LDL and HDL subclasses in patients with CRC, with an aim to determine whether advanced lipid testing might be useful in predicting the risk for the onset of this malignancy. Materials and methods: This case-control study included 84 patients with newly diagnosed CRC and 92 controls. Gradient gel electrophoresis was applied for separation of lipoprotein subclasses and for LDL and HDL diameters determination. Lipid parameters were measured using routine enzymatic methods. Results: Total cholesterol, HDL and LDL-cholesterol were significantly lower in CRC patients compared to controls (4.47 mmol/L vs. 5.63 mmol/L; 0.99 mmol/L vs. 1.27 mmol/L; 2.90 mmol/L vs. 3.66 mmol/L; P lt ...0.001, respectively). Patients had significantly smaller LDL (25.14 nm vs. 26.92 nm; P lt 0.001) and HDL diameters (8.76 nm vs. 10.17 nm; P lt 0.001) and greater proportion of small, dense LDL particles (54.0% vs. 52.9%; P = 0.044) than controls. Decreased LDL and HDL diameters were independent predictors of CRC (OR = 0.5, P = 0.001 and OR = 0.5, P = 0.008, respectively), and alongside with age and HDL-cholesterol concentrations formed the optimal cost-effective model, providing adequate discriminative abilities for CRC (AUC = 0.89) and correct patients classification (81%). Conclusions: Patients with CRC have decreased LDL and HDL diameters and increased proportion of smaller particles. LDL and HDL diameters determination could be useful in assessing the risk for CRC development.
Keywords:
colorectal cancer / risk prediction / lipoprotein subclasses / lipoprotein size / cost-effectivenessSource:
Biochemia Medica, 2018, 28, 3Publisher:
- Croatian Soc Medical Biochemists, Zagreb
Funding / projects:
DOI: 10.11613/BM.2018.030713
ISSN: 1330-0962
PubMed: 30429670
WoS: 000448275400016
Scopus: 2-s2.0-85055571303
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Institution/Community
PharmacyTY - JOUR AU - Stevanović, Milica AU - Vekić, Jelena AU - Bogavac-Stanojević, Nataša AU - Janać, Jelena AU - Stjepanović, Željka AU - Zeljković, Dejan AU - Trifunović, Bratislav AU - Spasojević-Kalimanovska, Vesna AU - Zeljković, Aleksandra PY - 2018 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3048 AB - Introduction: Dyslipidaemia contributes to the occurrence of colorectal cancer (CRC). We hypothesized that qualitative changes of lipoproteins are associated with the risk for CRC development. This study analyses low-density lipoprotein (LDL) and high-density lipoprotein (HDL) diameters, as well as distribution of LDL and HDL subclasses in patients with CRC, with an aim to determine whether advanced lipid testing might be useful in predicting the risk for the onset of this malignancy. Materials and methods: This case-control study included 84 patients with newly diagnosed CRC and 92 controls. Gradient gel electrophoresis was applied for separation of lipoprotein subclasses and for LDL and HDL diameters determination. Lipid parameters were measured using routine enzymatic methods. Results: Total cholesterol, HDL and LDL-cholesterol were significantly lower in CRC patients compared to controls (4.47 mmol/L vs. 5.63 mmol/L; 0.99 mmol/L vs. 1.27 mmol/L; 2.90 mmol/L vs. 3.66 mmol/L; P lt 0.001, respectively). Patients had significantly smaller LDL (25.14 nm vs. 26.92 nm; P lt 0.001) and HDL diameters (8.76 nm vs. 10.17 nm; P lt 0.001) and greater proportion of small, dense LDL particles (54.0% vs. 52.9%; P = 0.044) than controls. Decreased LDL and HDL diameters were independent predictors of CRC (OR = 0.5, P = 0.001 and OR = 0.5, P = 0.008, respectively), and alongside with age and HDL-cholesterol concentrations formed the optimal cost-effective model, providing adequate discriminative abilities for CRC (AUC = 0.89) and correct patients classification (81%). Conclusions: Patients with CRC have decreased LDL and HDL diameters and increased proportion of smaller particles. LDL and HDL diameters determination could be useful in assessing the risk for CRC development. PB - Croatian Soc Medical Biochemists, Zagreb T2 - Biochemia Medica T1 - Significance of LDL and HDL subclasses characterization in the assessment of risk for colorectal cancer development VL - 28 IS - 3 DO - 10.11613/BM.2018.030713 ER -
@article{ author = "Stevanović, Milica and Vekić, Jelena and Bogavac-Stanojević, Nataša and Janać, Jelena and Stjepanović, Željka and Zeljković, Dejan and Trifunović, Bratislav and Spasojević-Kalimanovska, Vesna and Zeljković, Aleksandra", year = "2018", abstract = "Introduction: Dyslipidaemia contributes to the occurrence of colorectal cancer (CRC). We hypothesized that qualitative changes of lipoproteins are associated with the risk for CRC development. This study analyses low-density lipoprotein (LDL) and high-density lipoprotein (HDL) diameters, as well as distribution of LDL and HDL subclasses in patients with CRC, with an aim to determine whether advanced lipid testing might be useful in predicting the risk for the onset of this malignancy. Materials and methods: This case-control study included 84 patients with newly diagnosed CRC and 92 controls. Gradient gel electrophoresis was applied for separation of lipoprotein subclasses and for LDL and HDL diameters determination. Lipid parameters were measured using routine enzymatic methods. Results: Total cholesterol, HDL and LDL-cholesterol were significantly lower in CRC patients compared to controls (4.47 mmol/L vs. 5.63 mmol/L; 0.99 mmol/L vs. 1.27 mmol/L; 2.90 mmol/L vs. 3.66 mmol/L; P lt 0.001, respectively). Patients had significantly smaller LDL (25.14 nm vs. 26.92 nm; P lt 0.001) and HDL diameters (8.76 nm vs. 10.17 nm; P lt 0.001) and greater proportion of small, dense LDL particles (54.0% vs. 52.9%; P = 0.044) than controls. Decreased LDL and HDL diameters were independent predictors of CRC (OR = 0.5, P = 0.001 and OR = 0.5, P = 0.008, respectively), and alongside with age and HDL-cholesterol concentrations formed the optimal cost-effective model, providing adequate discriminative abilities for CRC (AUC = 0.89) and correct patients classification (81%). Conclusions: Patients with CRC have decreased LDL and HDL diameters and increased proportion of smaller particles. LDL and HDL diameters determination could be useful in assessing the risk for CRC development.", publisher = "Croatian Soc Medical Biochemists, Zagreb", journal = "Biochemia Medica", title = "Significance of LDL and HDL subclasses characterization in the assessment of risk for colorectal cancer development", volume = "28", number = "3", doi = "10.11613/BM.2018.030713" }
Stevanović, M., Vekić, J., Bogavac-Stanojević, N., Janać, J., Stjepanović, Ž., Zeljković, D., Trifunović, B., Spasojević-Kalimanovska, V.,& Zeljković, A.. (2018). Significance of LDL and HDL subclasses characterization in the assessment of risk for colorectal cancer development. in Biochemia Medica Croatian Soc Medical Biochemists, Zagreb., 28(3). https://doi.org/10.11613/BM.2018.030713
Stevanović M, Vekić J, Bogavac-Stanojević N, Janać J, Stjepanović Ž, Zeljković D, Trifunović B, Spasojević-Kalimanovska V, Zeljković A. Significance of LDL and HDL subclasses characterization in the assessment of risk for colorectal cancer development. in Biochemia Medica. 2018;28(3). doi:10.11613/BM.2018.030713 .
Stevanović, Milica, Vekić, Jelena, Bogavac-Stanojević, Nataša, Janać, Jelena, Stjepanović, Željka, Zeljković, Dejan, Trifunović, Bratislav, Spasojević-Kalimanovska, Vesna, Zeljković, Aleksandra, "Significance of LDL and HDL subclasses characterization in the assessment of risk for colorectal cancer development" in Biochemia Medica, 28, no. 3 (2018), https://doi.org/10.11613/BM.2018.030713 . .