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dc.creatorStevanović, Milica
dc.creatorVekić, Jelena
dc.creatorBogavac-Stanojević, Nataša
dc.creatorJanać, Jelena
dc.creatorStjepanović, Željka
dc.creatorZeljković, Dejan
dc.creatorTrifunović, Bratislav
dc.creatorSpasojević-Kalimanovska, Vesna
dc.creatorZeljković, Aleksandra
dc.date.accessioned2019-09-02T12:03:31Z
dc.date.available2019-09-02T12:03:31Z
dc.date.issued2018
dc.identifier.issn1330-0962
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/3048
dc.description.abstractIntroduction: Dyslipidaemia contributes to the occurrence of colorectal cancer (CRC). We hypothesized that qualitative changes of lipoproteins are associated with the risk for CRC development. This study analyses low-density lipoprotein (LDL) and high-density lipoprotein (HDL) diameters, as well as distribution of LDL and HDL subclasses in patients with CRC, with an aim to determine whether advanced lipid testing might be useful in predicting the risk for the onset of this malignancy. Materials and methods: This case-control study included 84 patients with newly diagnosed CRC and 92 controls. Gradient gel electrophoresis was applied for separation of lipoprotein subclasses and for LDL and HDL diameters determination. Lipid parameters were measured using routine enzymatic methods. Results: Total cholesterol, HDL and LDL-cholesterol were significantly lower in CRC patients compared to controls (4.47 mmol/L vs. 5.63 mmol/L; 0.99 mmol/L vs. 1.27 mmol/L; 2.90 mmol/L vs. 3.66 mmol/L; P lt 0.001, respectively). Patients had significantly smaller LDL (25.14 nm vs. 26.92 nm; P lt 0.001) and HDL diameters (8.76 nm vs. 10.17 nm; P lt 0.001) and greater proportion of small, dense LDL particles (54.0% vs. 52.9%; P = 0.044) than controls. Decreased LDL and HDL diameters were independent predictors of CRC (OR = 0.5, P = 0.001 and OR = 0.5, P = 0.008, respectively), and alongside with age and HDL-cholesterol concentrations formed the optimal cost-effective model, providing adequate discriminative abilities for CRC (AUC = 0.89) and correct patients classification (81%). Conclusions: Patients with CRC have decreased LDL and HDL diameters and increased proportion of smaller particles. LDL and HDL diameters determination could be useful in assessing the risk for CRC development.en
dc.publisherCroatian Soc Medical Biochemists, Zagreb
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175035/RS//
dc.rightsopenAccess
dc.sourceBiochemia Medica
dc.subjectcolorectal canceren
dc.subjectrisk predictionen
dc.subjectlipoprotein subclassesen
dc.subjectlipoprotein sizeen
dc.subjectcost-effectivenessen
dc.titleSignificance of LDL and HDL subclasses characterization in the assessment of risk for colorectal cancer developmenten
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСтевановић, Милица; Јанац, Јелена; Зељковић, Aлександра; Векић, Јелена; Трифуновић, Братислав; Спасојевић-Калимановска, Весна; Зељковић, Дејан; Стјепановић, Жељка; Богавац-Станојевић, Наташа;
dc.citation.volume28
dc.citation.issue3
dc.citation.other28(3): -
dc.citation.rankM22
dc.identifier.wos000448275400016
dc.identifier.doi10.11613/BM.2018.030713
dc.identifier.pmid30429670
dc.identifier.scopus2-s2.0-85055571303
dc.identifier.fulltexthttps://farfar.pharmacy.bg.ac.rs//bitstream/id/1654/3046.pdf
dc.type.versionpublishedVersion


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