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Potentiation of the ibuprofen antihyperalgesic effect using inorganically functionalized diatomite

Authorized Users Only
2018
Authors
Janićijević, Jelena
Milić, Jela
Čalija, Bojan
Micov, Ana
Stepanović-Petrović, Radica
Tomić, Maja
Daković, Aleksandra
Dobričić, Vladimir
Nedić-Vasiljević, Bojana
Krajišnik, Danina
Article (Published version)
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Abstract
Refined diatomite from the Kolubara coal basin (Serbia) was inorganically functionalized through a simple, one-pot, non-time-consuming procedure. Model drug ibuprofen was adsorbed on the functionalized diatomite under optimized conditions providing high drug Loading (similar to 201 mg g(-1)). Physicochemical characterization was performed on the starting and modified diatomite before and after ibuprofen adsorption. Dissolution testing was conducted on comprimates containing the drug adsorbed on the modified diatomite (composite) and those containing a physical mixture of the drug with the modified diatomite. The antihyperalgesic and the antiedematous activity of ibuprofen from both composites and physical mixtures were evaluated in vivo employing an inflammatory pain model in rats. Functionalization and subsequent drug adsorption had no significant effect on the diatomite ordered porous structure. Two forms of ibuprofen most likely coexisted in the adsorbed state - the acidic form and ...a salt/complex with aluminium. Both comprimate types showed extended ibuprofen release in vitro, but no significant influence on the duration of the ibuprofen effect was observed upon in vivo application of the composite or physical mixture. However, both the composite and the physical mixture were more effective than equivalent doses of ibuprofen in pain suppression in rats. This potentiation of the ibuprofen antihyperalgesic effect may result from the formation of the drug complex with the carrier and can be of clinical relevance.

Source:
Journal of Materials Chemistry B, 2018, 6, 36, 5812-5822
Publisher:
  • Royal Soc Chemistry, Cambridge
Funding / projects:
  • Development of micro- and nanosystems as carriers for drugs with anti-inflammatory effect and methods for their characterization (RS-34031)

DOI: 10.1039/c8tb01376d

ISSN: 2050-750X

WoS: 000448413200016

Scopus: 2-s2.0-85053728185
[ Google Scholar ]
8
4
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/3050
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Janićijević, Jelena
AU  - Milić, Jela
AU  - Čalija, Bojan
AU  - Micov, Ana
AU  - Stepanović-Petrović, Radica
AU  - Tomić, Maja
AU  - Daković, Aleksandra
AU  - Dobričić, Vladimir
AU  - Nedić-Vasiljević, Bojana
AU  - Krajišnik, Danina
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3050
AB  - Refined diatomite from the Kolubara coal basin (Serbia) was inorganically functionalized through a simple, one-pot, non-time-consuming procedure. Model drug ibuprofen was adsorbed on the functionalized diatomite under optimized conditions providing high drug Loading (similar to 201 mg g(-1)). Physicochemical characterization was performed on the starting and modified diatomite before and after ibuprofen adsorption. Dissolution testing was conducted on comprimates containing the drug adsorbed on the modified diatomite (composite) and those containing a physical mixture of the drug with the modified diatomite. The antihyperalgesic and the antiedematous activity of ibuprofen from both composites and physical mixtures were evaluated in vivo employing an inflammatory pain model in rats. Functionalization and subsequent drug adsorption had no significant effect on the diatomite ordered porous structure. Two forms of ibuprofen most likely coexisted in the adsorbed state - the acidic form and a salt/complex with aluminium. Both comprimate types showed extended ibuprofen release in vitro, but no significant influence on the duration of the ibuprofen effect was observed upon in vivo application of the composite or physical mixture. However, both the composite and the physical mixture were more effective than equivalent doses of ibuprofen in pain suppression in rats. This potentiation of the ibuprofen antihyperalgesic effect may result from the formation of the drug complex with the carrier and can be of clinical relevance.
PB  - Royal Soc Chemistry, Cambridge
T2  - Journal of Materials Chemistry B
T1  - Potentiation of the ibuprofen antihyperalgesic effect using inorganically functionalized diatomite
VL  - 6
IS  - 36
SP  - 5812
EP  - 5822
DO  - 10.1039/c8tb01376d
ER  - 
@article{
author = "Janićijević, Jelena and Milić, Jela and Čalija, Bojan and Micov, Ana and Stepanović-Petrović, Radica and Tomić, Maja and Daković, Aleksandra and Dobričić, Vladimir and Nedić-Vasiljević, Bojana and Krajišnik, Danina",
year = "2018",
abstract = "Refined diatomite from the Kolubara coal basin (Serbia) was inorganically functionalized through a simple, one-pot, non-time-consuming procedure. Model drug ibuprofen was adsorbed on the functionalized diatomite under optimized conditions providing high drug Loading (similar to 201 mg g(-1)). Physicochemical characterization was performed on the starting and modified diatomite before and after ibuprofen adsorption. Dissolution testing was conducted on comprimates containing the drug adsorbed on the modified diatomite (composite) and those containing a physical mixture of the drug with the modified diatomite. The antihyperalgesic and the antiedematous activity of ibuprofen from both composites and physical mixtures were evaluated in vivo employing an inflammatory pain model in rats. Functionalization and subsequent drug adsorption had no significant effect on the diatomite ordered porous structure. Two forms of ibuprofen most likely coexisted in the adsorbed state - the acidic form and a salt/complex with aluminium. Both comprimate types showed extended ibuprofen release in vitro, but no significant influence on the duration of the ibuprofen effect was observed upon in vivo application of the composite or physical mixture. However, both the composite and the physical mixture were more effective than equivalent doses of ibuprofen in pain suppression in rats. This potentiation of the ibuprofen antihyperalgesic effect may result from the formation of the drug complex with the carrier and can be of clinical relevance.",
publisher = "Royal Soc Chemistry, Cambridge",
journal = "Journal of Materials Chemistry B",
title = "Potentiation of the ibuprofen antihyperalgesic effect using inorganically functionalized diatomite",
volume = "6",
number = "36",
pages = "5812-5822",
doi = "10.1039/c8tb01376d"
}
Janićijević, J., Milić, J., Čalija, B., Micov, A., Stepanović-Petrović, R., Tomić, M., Daković, A., Dobričić, V., Nedić-Vasiljević, B.,& Krajišnik, D.. (2018). Potentiation of the ibuprofen antihyperalgesic effect using inorganically functionalized diatomite. in Journal of Materials Chemistry B
Royal Soc Chemistry, Cambridge., 6(36), 5812-5822.
https://doi.org/10.1039/c8tb01376d
Janićijević J, Milić J, Čalija B, Micov A, Stepanović-Petrović R, Tomić M, Daković A, Dobričić V, Nedić-Vasiljević B, Krajišnik D. Potentiation of the ibuprofen antihyperalgesic effect using inorganically functionalized diatomite. in Journal of Materials Chemistry B. 2018;6(36):5812-5822.
doi:10.1039/c8tb01376d .
Janićijević, Jelena, Milić, Jela, Čalija, Bojan, Micov, Ana, Stepanović-Petrović, Radica, Tomić, Maja, Daković, Aleksandra, Dobričić, Vladimir, Nedić-Vasiljević, Bojana, Krajišnik, Danina, "Potentiation of the ibuprofen antihyperalgesic effect using inorganically functionalized diatomite" in Journal of Materials Chemistry B, 6, no. 36 (2018):5812-5822,
https://doi.org/10.1039/c8tb01376d . .

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