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dc.creatorNinić, Ana
dc.creatorSpasojević-Kalimanovska, Vesna
dc.creatorSopić, Miron
dc.creatorMunjas, Jelena
dc.creatorBogavac-Stanojević, Nataša
dc.creatorJelić-Ivanović, Zorana
dc.creatorKotur-Stevuljević, Jelena
dc.creatorSpasić, Slavica
dc.creatorCrevar-Sakač, Milkica
dc.creatorMilenković, Marina
dc.creatorVujić, Zorica
dc.date.accessioned2019-09-02T12:03:38Z
dc.date.available2019-09-02T12:03:38Z
dc.date.issued2018
dc.identifier.issn0972-5849
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/3054
dc.description.abstractParaoxonases isoenzymes, PON1, PON2 and PON3, have important antioxidative and anti-inflammatory properties in blood and cells. They prevent oxidation of low and high density lipoprotein particles, foam cells formation and development of atherosclerosis. The authors investigated effects of high fat diet and atorvastatin therapy on paraoxonases gene expression levels and distribution in different rat organs. Liver, white adipose tissue (WAT) and aorta were taken from young male Wistar rats that were fed with normal diet (ND), atherogenic diet (AD) and atherogenic diet with 1.14 mg of atorvastatin per kg (ADA). Messenger RNA (mRNA) relative levels of paraoxonase 1 (PON1), paraoxonase 2 (PON2) and paraoxonase 3 (PON3) were measured in rat organs using real-time polymerase chain reaction (PCR). PON1 mRNA expression levels were down-regulated in ADA compared to AD group. ND group had significantly lower PON2 mRNA expression than AD group. PON1 mRNA expression levels were higher in liver than in aorta in group of rats on ND, AD and ADA. PON2 mRNA expression was higher in WAT than in aorta only in ADA group of rats. PON2 and PON3 were significantly higher than PON1 in aorta of rats on each ND, AD or ADA.en
dc.publisherNatl Inst Science Communication-Niscair, New Delhi
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175035/RS//
dc.rightsrestrictedAccess
dc.sourceIndian Journal of Biotechnology
dc.subjectParaoxonaseen
dc.subjectgene expressionen
dc.subjectatorvastatinen
dc.subjectatherogenic dieten
dc.subjectraten
dc.titleParaoxonases gene expression and distribution in rats organs treated with atherogenic diet and atorvastatin therapyen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМуњас, Јелена; Котур-Стевуљевић, Јелена; Јелић-Ивановић, Зорана; Нинић, Aна; Сопић, Мирон; Богавац-Станојевић, Наташа; Спасојевић-Калимановска, Весна; Вујић, Зорица; Спасић, Славица; Цревар-Сакач, Милкица; Миленковић, Марина;
dc.citation.volume17
dc.citation.issue2
dc.citation.spage217
dc.citation.epage223
dc.citation.other17(2): 217-223
dc.citation.rankM23
dc.identifier.wos000447574800003
dc.identifier.scopus2-s2.0-85055313997
dc.identifier.rcubconv_4230
dc.type.versionpublishedVersion


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