Antibiotic consumption and healthcare-associated infections in a tertiary hospital in Belgrade, Serbia from 2011 to 2016

2018
Authors
Perić, Aneta
Dragojević-Simić, Viktorija
Milenković, Bojana
Vezmar-Kovačević, Sandra

Suljagić, Vesna
Article (Published version)

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Introduction: Healthcare-associated infections (HAIs) and irrational use of antibiotics in healthcare settings are major global public health concerns. Surveillance of HAIs in intensive care units (ICU), surgical-site infections (SSIs), and Clostridium difficile infections (CDIs), together with implementation of antibiotic stewardship, are cornerstones of hospital infection prevention programs. The aim of this study was to evaluate antibiotic consumption, especially of broad spectrum antibiotics, in relation to HAI incidence density (ID). Methodology: The study was conducted from 2011 to 2016 in a tertiary hospital, the Military Medical Academy (MMA), in Belgrade, Serbia. Through regular hospital surveillance we identified all patients with a new HAI. Data on consumption of antibacterials for systemic use were expressed as defined daily dose per 100 bed days (DDD/100 BD). Results: The highest incidence density (ID) of HAI was observed among patients in surgical ICUs (47.2 per 1000 pati...ent-days), while the highest incidence rate among SSI was 3.7%. Moreover, the highest ID of CDI in medical patients was 6.2 per 10,000 patient-days, while in surgical patients it was 4.3 per 10,000 patient-days. The most frequently used antibiotics were cephalosporins, aminoglycosides and carbapenems (16.0 +/- 2.3, 4.8 +/- 0.7, 4.3 f 0.7 DDD/100 BD, respectively). There was no significant correlation between consumption of any groups of antibiotics and ID of CDI in medical and surgical patients. Conclusion: The multidisciplinary healthcare team would have crucial importance in the implementation of the antibiotic stewardship program in order to decrease unnecessary exposures of patients treated in healthcare settings.
Keywords:
Clostridium infections / cephalosporins / carbapenems / surgical site infectionSource:
Journal of Infection in Developing Countries, 2018, 12, 10, 855-863Publisher:
- J Infection Developing Countries, Tramaniglio
Funding / projects:
- Ministry of Defence of the Republic of Serbia (Project no. MF/VMA/02/17-19)
DOI: 10.3855/jidc.10827
ISSN: 1972-2680
WoS: 000449742200006
Scopus: 2-s2.0-85060985420
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PharmacyTY - JOUR AU - Perić, Aneta AU - Dragojević-Simić, Viktorija AU - Milenković, Bojana AU - Vezmar-Kovačević, Sandra AU - Suljagić, Vesna PY - 2018 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3057 AB - Introduction: Healthcare-associated infections (HAIs) and irrational use of antibiotics in healthcare settings are major global public health concerns. Surveillance of HAIs in intensive care units (ICU), surgical-site infections (SSIs), and Clostridium difficile infections (CDIs), together with implementation of antibiotic stewardship, are cornerstones of hospital infection prevention programs. The aim of this study was to evaluate antibiotic consumption, especially of broad spectrum antibiotics, in relation to HAI incidence density (ID). Methodology: The study was conducted from 2011 to 2016 in a tertiary hospital, the Military Medical Academy (MMA), in Belgrade, Serbia. Through regular hospital surveillance we identified all patients with a new HAI. Data on consumption of antibacterials for systemic use were expressed as defined daily dose per 100 bed days (DDD/100 BD). Results: The highest incidence density (ID) of HAI was observed among patients in surgical ICUs (47.2 per 1000 patient-days), while the highest incidence rate among SSI was 3.7%. Moreover, the highest ID of CDI in medical patients was 6.2 per 10,000 patient-days, while in surgical patients it was 4.3 per 10,000 patient-days. The most frequently used antibiotics were cephalosporins, aminoglycosides and carbapenems (16.0 +/- 2.3, 4.8 +/- 0.7, 4.3 f 0.7 DDD/100 BD, respectively). There was no significant correlation between consumption of any groups of antibiotics and ID of CDI in medical and surgical patients. Conclusion: The multidisciplinary healthcare team would have crucial importance in the implementation of the antibiotic stewardship program in order to decrease unnecessary exposures of patients treated in healthcare settings. PB - J Infection Developing Countries, Tramaniglio T2 - Journal of Infection in Developing Countries T1 - Antibiotic consumption and healthcare-associated infections in a tertiary hospital in Belgrade, Serbia from 2011 to 2016 VL - 12 IS - 10 SP - 855 EP - 863 DO - 10.3855/jidc.10827 ER -
@article{ author = "Perić, Aneta and Dragojević-Simić, Viktorija and Milenković, Bojana and Vezmar-Kovačević, Sandra and Suljagić, Vesna", year = "2018", abstract = "Introduction: Healthcare-associated infections (HAIs) and irrational use of antibiotics in healthcare settings are major global public health concerns. Surveillance of HAIs in intensive care units (ICU), surgical-site infections (SSIs), and Clostridium difficile infections (CDIs), together with implementation of antibiotic stewardship, are cornerstones of hospital infection prevention programs. The aim of this study was to evaluate antibiotic consumption, especially of broad spectrum antibiotics, in relation to HAI incidence density (ID). Methodology: The study was conducted from 2011 to 2016 in a tertiary hospital, the Military Medical Academy (MMA), in Belgrade, Serbia. Through regular hospital surveillance we identified all patients with a new HAI. Data on consumption of antibacterials for systemic use were expressed as defined daily dose per 100 bed days (DDD/100 BD). Results: The highest incidence density (ID) of HAI was observed among patients in surgical ICUs (47.2 per 1000 patient-days), while the highest incidence rate among SSI was 3.7%. Moreover, the highest ID of CDI in medical patients was 6.2 per 10,000 patient-days, while in surgical patients it was 4.3 per 10,000 patient-days. The most frequently used antibiotics were cephalosporins, aminoglycosides and carbapenems (16.0 +/- 2.3, 4.8 +/- 0.7, 4.3 f 0.7 DDD/100 BD, respectively). There was no significant correlation between consumption of any groups of antibiotics and ID of CDI in medical and surgical patients. Conclusion: The multidisciplinary healthcare team would have crucial importance in the implementation of the antibiotic stewardship program in order to decrease unnecessary exposures of patients treated in healthcare settings.", publisher = "J Infection Developing Countries, Tramaniglio", journal = "Journal of Infection in Developing Countries", title = "Antibiotic consumption and healthcare-associated infections in a tertiary hospital in Belgrade, Serbia from 2011 to 2016", volume = "12", number = "10", pages = "855-863", doi = "10.3855/jidc.10827" }
Perić, A., Dragojević-Simić, V., Milenković, B., Vezmar-Kovačević, S.,& Suljagić, V.. (2018). Antibiotic consumption and healthcare-associated infections in a tertiary hospital in Belgrade, Serbia from 2011 to 2016. in Journal of Infection in Developing Countries J Infection Developing Countries, Tramaniglio., 12(10), 855-863. https://doi.org/10.3855/jidc.10827
Perić A, Dragojević-Simić V, Milenković B, Vezmar-Kovačević S, Suljagić V. Antibiotic consumption and healthcare-associated infections in a tertiary hospital in Belgrade, Serbia from 2011 to 2016. in Journal of Infection in Developing Countries. 2018;12(10):855-863. doi:10.3855/jidc.10827 .
Perić, Aneta, Dragojević-Simić, Viktorija, Milenković, Bojana, Vezmar-Kovačević, Sandra, Suljagić, Vesna, "Antibiotic consumption and healthcare-associated infections in a tertiary hospital in Belgrade, Serbia from 2011 to 2016" in Journal of Infection in Developing Countries, 12, no. 10 (2018):855-863, https://doi.org/10.3855/jidc.10827 . .