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Association between neurological soft signs and antioxidant enzyme activity in schizophrenic patients

Authorized Users Only
2018
Authors
Miljević, Čedo D.
Nikolić-Kokić, Aleksandra
Blagojević, Duško
Milovanović, Maja
Munjiza, Ana
Jukić, Marin
Pešić, Vesna
Lecić-Tosevski, Dušica
Spasić, Mihajlo B.
Article (Published version)
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Abstract
To determine the relationship between alterations in the activity of the enzymes participating in antioxidative defense system and neurological soft signs (NSS) in schizophrenic patients with the first episode psychosis (S-FE, n = 19), patients in relapse (S-R, n = 46), and healthy controls (HC, n = 20). NSS intensity and enzymatic plasma activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX) were compared between S-FE, S-R and HC subjects and a follow-up correlation analyses between the enzyme activities and NSS intensity was performed. NSS intensity was increased four times in schizophrenic patients compared with healthy controls. Activities of SOD and CAT were 40% decreased in S-FE and these reductions were ameliorated by antipsychotic treatment. GPX activity was 20% decreased in both patient groups compared with controls. A negative correlation between NSS intensity and GPX activity was specifically found in the S-FE patients. The data in this re...port argue that a reduction of GPX activity might be one of the causes for the emergence of NSS at the onset of schizophrenia, and provide the evidence that antipsychotic therapy can attenuate activity reductions of SOD and CAT, but not the activity reduction of GPX and the intensity of NSS.

Source:
Psychoneuroendocrinology, 2018, 269, 746-752
Publisher:
  • Elsevier Ireland Ltd, Clare
Projects:
  • Molecular mechanisms of redox signalling in homeostasis: adaptation and pathology (RS-173014)

DOI: 10.1016/j.psychres.2018.09.009

ISSN: 0165-1781

PubMed: 30273900

WoS: 000449902700107

Scopus: 2-s2.0-85053528799
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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/3058
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Institution
Pharmacy

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