Association between neurological soft signs and antioxidant enzyme activity in schizophrenic patients
Само за регистроване кориснике
2018
Аутори
Miljević, Čedo D.Nikolić-Kokić, Aleksandra
Blagojević, Duško
Milovanović, Maja
Munjiza, Ana
Jukić, Marin
Pešić, Vesna
Lecić-Tosevski, Dušica
Spasić, Mihajlo B.
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
To determine the relationship between alterations in the activity of the enzymes participating in antioxidative defense system and neurological soft signs (NSS) in schizophrenic patients with the first episode psychosis (S-FE, n = 19), patients in relapse (S-R, n = 46), and healthy controls (HC, n = 20). NSS intensity and enzymatic plasma activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX) were compared between S-FE, S-R and HC subjects and a follow-up correlation analyses between the enzyme activities and NSS intensity was performed. NSS intensity was increased four times in schizophrenic patients compared with healthy controls. Activities of SOD and CAT were 40% decreased in S-FE and these reductions were ameliorated by antipsychotic treatment. GPX activity was 20% decreased in both patient groups compared with controls. A negative correlation between NSS intensity and GPX activity was specifically found in the S-FE patients. The data in this re...port argue that a reduction of GPX activity might be one of the causes for the emergence of NSS at the onset of schizophrenia, and provide the evidence that antipsychotic therapy can attenuate activity reductions of SOD and CAT, but not the activity reduction of GPX and the intensity of NSS.
Извор:
Psychoneuroendocrinology, 2018, 269, 746-752Издавач:
- Elsevier Ireland Ltd, Clare
Финансирање / пројекти:
- Молекуларни механизми редокс сигналинга у хомеостази, адаптацији и патологији (RS-MESTD-Basic Research (BR or ON)-173014)
DOI: 10.1016/j.psychres.2018.09.009
ISSN: 0165-1781
PubMed: 30273900
WoS: 000449902700107
Scopus: 2-s2.0-85053528799
Институција/група
PharmacyTY - JOUR AU - Miljević, Čedo D. AU - Nikolić-Kokić, Aleksandra AU - Blagojević, Duško AU - Milovanović, Maja AU - Munjiza, Ana AU - Jukić, Marin AU - Pešić, Vesna AU - Lecić-Tosevski, Dušica AU - Spasić, Mihajlo B. PY - 2018 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3058 AB - To determine the relationship between alterations in the activity of the enzymes participating in antioxidative defense system and neurological soft signs (NSS) in schizophrenic patients with the first episode psychosis (S-FE, n = 19), patients in relapse (S-R, n = 46), and healthy controls (HC, n = 20). NSS intensity and enzymatic plasma activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX) were compared between S-FE, S-R and HC subjects and a follow-up correlation analyses between the enzyme activities and NSS intensity was performed. NSS intensity was increased four times in schizophrenic patients compared with healthy controls. Activities of SOD and CAT were 40% decreased in S-FE and these reductions were ameliorated by antipsychotic treatment. GPX activity was 20% decreased in both patient groups compared with controls. A negative correlation between NSS intensity and GPX activity was specifically found in the S-FE patients. The data in this report argue that a reduction of GPX activity might be one of the causes for the emergence of NSS at the onset of schizophrenia, and provide the evidence that antipsychotic therapy can attenuate activity reductions of SOD and CAT, but not the activity reduction of GPX and the intensity of NSS. PB - Elsevier Ireland Ltd, Clare T2 - Psychoneuroendocrinology T1 - Association between neurological soft signs and antioxidant enzyme activity in schizophrenic patients VL - 269 SP - 746 EP - 752 DO - 10.1016/j.psychres.2018.09.009 ER -
@article{ author = "Miljević, Čedo D. and Nikolić-Kokić, Aleksandra and Blagojević, Duško and Milovanović, Maja and Munjiza, Ana and Jukić, Marin and Pešić, Vesna and Lecić-Tosevski, Dušica and Spasić, Mihajlo B.", year = "2018", abstract = "To determine the relationship between alterations in the activity of the enzymes participating in antioxidative defense system and neurological soft signs (NSS) in schizophrenic patients with the first episode psychosis (S-FE, n = 19), patients in relapse (S-R, n = 46), and healthy controls (HC, n = 20). NSS intensity and enzymatic plasma activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX) were compared between S-FE, S-R and HC subjects and a follow-up correlation analyses between the enzyme activities and NSS intensity was performed. NSS intensity was increased four times in schizophrenic patients compared with healthy controls. Activities of SOD and CAT were 40% decreased in S-FE and these reductions were ameliorated by antipsychotic treatment. GPX activity was 20% decreased in both patient groups compared with controls. A negative correlation between NSS intensity and GPX activity was specifically found in the S-FE patients. The data in this report argue that a reduction of GPX activity might be one of the causes for the emergence of NSS at the onset of schizophrenia, and provide the evidence that antipsychotic therapy can attenuate activity reductions of SOD and CAT, but not the activity reduction of GPX and the intensity of NSS.", publisher = "Elsevier Ireland Ltd, Clare", journal = "Psychoneuroendocrinology", title = "Association between neurological soft signs and antioxidant enzyme activity in schizophrenic patients", volume = "269", pages = "746-752", doi = "10.1016/j.psychres.2018.09.009" }
Miljević, Č. D., Nikolić-Kokić, A., Blagojević, D., Milovanović, M., Munjiza, A., Jukić, M., Pešić, V., Lecić-Tosevski, D.,& Spasić, M. B.. (2018). Association between neurological soft signs and antioxidant enzyme activity in schizophrenic patients. in Psychoneuroendocrinology Elsevier Ireland Ltd, Clare., 269, 746-752. https://doi.org/10.1016/j.psychres.2018.09.009
Miljević ČD, Nikolić-Kokić A, Blagojević D, Milovanović M, Munjiza A, Jukić M, Pešić V, Lecić-Tosevski D, Spasić MB. Association between neurological soft signs and antioxidant enzyme activity in schizophrenic patients. in Psychoneuroendocrinology. 2018;269:746-752. doi:10.1016/j.psychres.2018.09.009 .
Miljević, Čedo D., Nikolić-Kokić, Aleksandra, Blagojević, Duško, Milovanović, Maja, Munjiza, Ana, Jukić, Marin, Pešić, Vesna, Lecić-Tosevski, Dušica, Spasić, Mihajlo B., "Association between neurological soft signs and antioxidant enzyme activity in schizophrenic patients" in Psychoneuroendocrinology, 269 (2018):746-752, https://doi.org/10.1016/j.psychres.2018.09.009 . .