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dc.creatorMiljević, Čedo D.
dc.creatorNikolić-Kokić, Aleksandra
dc.creatorBlagojević, Duško
dc.creatorMilovanović, Maja
dc.creatorMunjiza, Ana
dc.creatorJukić, Marin
dc.creatorPešić, Vesna
dc.creatorLecić-Tosevski, Dušica
dc.creatorSpasić, Mihajlo B.
dc.date.accessioned2019-09-02T12:03:44Z
dc.date.available2019-09-02T12:03:44Z
dc.date.issued2018
dc.identifier.issn0165-1781
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/3058
dc.description.abstractTo determine the relationship between alterations in the activity of the enzymes participating in antioxidative defense system and neurological soft signs (NSS) in schizophrenic patients with the first episode psychosis (S-FE, n = 19), patients in relapse (S-R, n = 46), and healthy controls (HC, n = 20). NSS intensity and enzymatic plasma activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX) were compared between S-FE, S-R and HC subjects and a follow-up correlation analyses between the enzyme activities and NSS intensity was performed. NSS intensity was increased four times in schizophrenic patients compared with healthy controls. Activities of SOD and CAT were 40% decreased in S-FE and these reductions were ameliorated by antipsychotic treatment. GPX activity was 20% decreased in both patient groups compared with controls. A negative correlation between NSS intensity and GPX activity was specifically found in the S-FE patients. The data in this report argue that a reduction of GPX activity might be one of the causes for the emergence of NSS at the onset of schizophrenia, and provide the evidence that antipsychotic therapy can attenuate activity reductions of SOD and CAT, but not the activity reduction of GPX and the intensity of NSS.en
dc.publisherElsevier Ireland Ltd, Clare
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173014/RS//
dc.rightsrestrictedAccess
dc.sourcePsychoneuroendocrinology
dc.titleAssociation between neurological soft signs and antioxidant enzyme activity in schizophrenic patientsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЛецић-Тосевски, Душица; Муњиза, Aна; Николић-Кокић, Aлександра; Пешић, Весна; Спасић, Михајло Б.; Јукић, Марин; Благојевић, Душко; Миљевић, Чедо Д.; Миловановић, Маја;
dc.citation.volume269
dc.citation.spage746
dc.citation.epage752
dc.citation.other269: 746-752
dc.citation.rankM22
dc.identifier.wos000449902700107
dc.identifier.doi10.1016/j.psychres.2018.09.009
dc.identifier.pmid30273900
dc.identifier.scopus2-s2.0-85053528799
dc.identifier.rcubconv_4254
dc.type.versionpublishedVersion


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