Show simple item record

dc.creatorNinić, Ana
dc.creatorSopić, Miron
dc.creatorMunjas, Jelena
dc.creatorSpasojević-Kalimanovska, Vesna
dc.creatorKotur-Stevuljević, Jelena
dc.creatorBogavac-Stanojević, Nataša
dc.creatorIvanišević, Jasmina
dc.creatorSimić-Ogrizović, Sanja
dc.creatorKravljaca, Milica
dc.creatorJelić-Ivanović, Zorana
dc.date.accessioned2019-09-02T12:03:46Z
dc.date.available2019-09-02T12:03:46Z
dc.date.issued2018
dc.identifier.issn2146-3123
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/3060
dc.description.abstractBackground: Chronic renal failure, particularly end-stage renal disease, is a serious health problem associated with a high mortality rate. Uremic syndrome leads to increased oxidative stress, inflammation, and dyslipidemia. Aims: To examine superoxide dismutase isoenzyme gene expression in peripheral blood mononuclear cells of patients on hemodialysis and to determine the associations between superoxide dismutase isoenzyme gene expression, oxidative stress, and non-enzymatic antioxidative protection. Study Design: Case control study. Methods: This study included 33 patients on hemodialysis (age, 55.33 +/- 15.31 years old) and 33 apparently healthy controls (age, 45.37 +/- 8.92 years old). Superoxide dismutase isoenzyme messenger ribonucleic acid levels were determined by real-time polymerase chain reaction. General biochemical parameters, high sensitivity C-reactive protein, total antioxidant status, thiobarbituric acid-reactive substances, and the superoxide anion radical were also determined. Results: Normalized Cu/Zn superoxide dismutase and Mn superoxide dismutase messenger ribonucleic acid levels were significantly higher in patients than controls (p lt 0.001 and p=0.011). A significant negative correlation was detected between normalized Cu/Zn superoxide dismutase messenger ribonucleic acid levels and total protein total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and total antioxidant status. Normalized Mn superoxide dismutase messenger ribonucleic acid levels were negatively correlated with total protein and total antioxidant status. A multiple regression analysis revealed independent associations between total antioxidant status and normalized Cu/Zn superoxide dismutase (p=0.038) and between total antioxidant status and normalized Mn superoxide dismutase messenger ribonucleic acid levels (p=0.038 and p=0.018, respectively). Conclusion: The superoxide dismutase isoenzyme gene is expressed at a higher rate in patients with end-stage renal failure, probably due to increased oxidative stress and attenuated antioxidative defense. The plasma total antioxidant status is an independent predictor of normalized superoxide dismutase isoenzyme messenger ribonucleic acid levels.en
dc.publisherGalenos Yayincilik, Findikzade
dc.relationMinistry of Education, Science and Technological Development, Republic of Serbia
dc.rightsopenAccess
dc.sourceBalkan Medical Journal
dc.subjectAntioxidantsen
dc.subjectend stage renal diseaseen
dc.subjectribonucleic aciden
dc.subjectsuperoxide dismutaseen
dc.titleAssociation Between Superoxide Dismutase Isoenzyme Gene Expression and Total Antioxidant Status in Patients with an End-Stage Renal Diseaseen
dc.typearticle
dc.rights.licenseBY-NC-ND
dcterms.abstractБогавац-Станојевић, Наташа; Нинић, Aна; Сопић, Мирон; Јелић-Ивановић, Зорана; Спасојевић-Калимановска, Весна; Симић-Огризовић, Сања; Крављаца, Милица; Муњас, Јелена; Иванишевић, Јасмина; Котур-Стевуљевић, Јелена;
dc.citation.volume35
dc.citation.issue6
dc.citation.spage431
dc.citation.epage436
dc.citation.other35(6): 431-436
dc.citation.rankM22
dc.identifier.wos000450125700005
dc.identifier.doi10.4274/balkanmedj.2018.0170
dc.identifier.pmid30063213
dc.identifier.scopus2-s2.0-85056654372
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/1663/3058.pdf
dc.identifier.rcubconv_4258
dc.type.versionpublishedVersion


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record