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dc.creatorRadaković, Milena
dc.creatorBorozan, Sunčica
dc.creatorĐelić, Ninoslav
dc.creatorIvanović, Sasa
dc.creatorČupić-Miladinović, Dejana
dc.creatorRistanić, Marko
dc.creatorPotparević, Biljana
dc.creatorStanimirović, Zoran
dc.date.accessioned2019-09-02T12:03:52Z
dc.date.available2019-09-02T12:03:52Z
dc.date.issued2018
dc.identifier.issn1942-0900
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/3064
dc.description.abstractThis study is aimed at analysing biochemical and genetic endpoints of toxic effects after administration of adrenaline. For this purpose, the study was carried out on Wistar rats and three doses of adrenaline were used: 0.75 mg/kg, 1.5 mg/kg, and 3 mg/kg body weight. To achieve these aims, we investigated the effects of adrenaline on catalase (CAT), Cu, Zn-superoxide dismutase (SOD), malondialdehyde (MDA), nitrite (NO2-), carbonyl groups (PCC), and nitrotyrosine (3-NT). Total activity of lactate dehydrogenase (LDH), its relative distribution (LDH1-LDH5) activity, level of acute phase proteins (APPs), and genotoxic effect were also evaluated. The obtained results revealed that all doses of adrenaline induced a significant rise in CAT activity, MDA level, PCC, NO2-, and 3-NT and a significant decrease in SOD activity compared to control. Adrenaline exerted an increase in total activity of LDH, LDH1, and LDH2 isoenzymes. Further study showed that adrenaline significantly decreased serum albumin level and albumin-globulin ratio, while the level of APPs (alpha(1) -acid glycoprotein and haptoglobulin) is increased. The micronucleus test revealed a genotoxic effect of adrenaline at higher concentrations (1.5 mg/kg and 3 mg/kg body weight) compared to untreated rats. It can be concluded that adrenaline exerts oxidative and nitrative stress in rats, increased damage to lipids and proteins, and damage of cardiomyocytes and cytogenetic damage. Obtained results may contribute to better understanding of the toxicity of adrenaline with aims to preventing its harmful effects.en
dc.publisherHindawi Ltd, London
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173034/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceOxidative Medicine and Cellular Longevity
dc.titleNitroso-Oxidative Stress, Acute Phase Response, and Cytogenetic Damage in Wistar Rats Treated with Adrenalineen
dc.typearticle
dc.rights.licenseBY
dcterms.abstractРистанић, Марко; Ђелић, Нинослав; Чупић-Миладиновић, Дејана; Борозан, Сунчица; Станимировић, Зоран; Радаковић, Милена; Потпаревић, Биљана; Ивановић, Саса;
dc.citation.rankM21
dc.identifier.wos000451857700001
dc.identifier.doi10.1155/2018/1805354
dc.identifier.pmid30584458
dc.identifier.scopus2-s2.0-85058926303
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/1667/3062.pdf
dc.identifier.rcubconv_4265
dc.type.versionpublishedVersion


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