Приказ основних података о документу

dc.creatorSavić, Jelena
dc.creatorDilber, Sanda
dc.creatorVujić, Zorica
dc.creatorVladimirov, Sote
dc.creatorBrborić, Jasmina
dc.date.accessioned2019-09-02T12:03:59Z
dc.date.available2019-09-02T12:03:59Z
dc.date.issued2018
dc.identifier.issn0352-5139
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/3069
dc.description.abstractThe pK(a) values of twelve beta-hydroxy-beta-arylalkanoic acids and ibuprofen were determined using a modified RP-HPLC method. The stationary phase was octadecyl modified (C-18) silica gel, and the mobile phases were mixtures of methanol and one of ten different buffers (60: 40 volume ratio). The mean retention time of each compound was plotted against the pH of each of the ten used mobile phases. The inflection point of the obtained sigmoidal curve represents the (s)(w)pK(a) of a compound. Using (s)(w)pKa in previously established equations for the specific methanol/buffer mixture, the (w)(w)pK(a) values (in pure water) were calculated. The obtained wwpKa values for the synthesized compounds were in a range from 3.40 to 3.74, and the (w)(w)pK(a) for ibuprofen was 4.27. The Predicted pK(a) values for this type of compounds in the MarvinSketch 5.11.5. Program were in poor correlation with the experimental results, while in ACD//I-Labs pK(a) values were calculated as a wide range.en
dc.publisherSrpsko hemijsko društvo, Beograd
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172041/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceJournal of the Serbian Chemical Society
dc.subjectdissociation constanten
dc.subjectanti-inflammatory compoundsen
dc.subjectibuprofenen
dc.subjectliquid chromatographyen
dc.subjectcarboxylic acidsen
dc.titleA modified RP-HPLC method for the determination of the pK(a) values of synthesized beta-hydroxy-beta-arylalkanoic acidsen
dc.typearticle
dc.rights.licenseBY-NC-ND
dcterms.abstractВладимиров, Соте; Вујић, Зорица; Дилбер, Санда; Брборић, Јасмина; Савић, Јелена;
dc.citation.volume83
dc.citation.issue7-8
dc.citation.spage875
dc.citation.epage883
dc.citation.other83(7-8): 875-883
dc.citation.rankM23
dc.identifier.wos000441529600007
dc.identifier.doi10.2298/JSC170804045S
dc.identifier.scopus2-s2.0-85082361980
dc.identifier.fulltexthttps://farfar.pharmacy.bg.ac.rs//bitstream/id/1672/3067.pdf
dc.type.versionpublishedVersion


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Приказ основних података о документу