B-Type Natriuretic Peptide as a Marker of Different Forms of Systemic Sclerosis
2018
Аутори
Stefanović-Nešković, JelenaRistić, Andelka
Petronijević, Milan
Zeljković, Aleksandra
Grdinić, Aleksandra
Gudelj, Ognjen
Durović, Branka
Nesković, Branimir
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Background: Systemic sclerosis (SSc) is an autoimmune connective tissue disease which affects various tissues and organs, including skin, lungs, kidneys, gastrointestinal tract and cardiovascular system. Cardiac involvement is the most commonly recognized problem and a significant cause of morbidity. The brain natriuretic peptide (BNP) is a previously known marker of elevated cardiovascular risk in SSc, but the levels of BNP in various forms of SSc have not been investigated so far. Aim: The aim of our study was to evaluate the influence of SSc on the function of the right ventricle and the right atrium using the echocardiographic parameters. Moreover, we examined the levels of BNP in different forms of SSc as well as the association of disease severity with the plasma concentrations of BNP. Methods: We included 42 patients with newly diagnosed SSc and patients whose disease had been diagnosed earlier. SSc patients and non-SSc control patients were examined by using echocardiography an...d the concentrations of BNP were determined. Results: We analyzed differences in the parameters of right ventricle (RV) function and right atrium (RA) function between SSc patients and healthy controls. The two groups had similar distribution of gender, but SSc patients were significantly older than controls. RV wall thickness was increased in SSc patients (p lt 0.001), while right ventricular end-systolic area (RVEDA; p=0.408) and right ventricular end-diastolic area (RVEDA; p=0.368) did not differ among the examinees. In contrast, RA minor-axis dimension (p=0.001) and the tricuspid annular plane systolic excursion (TAPSE) (p=0.001) were significantly higher in SSc patients. Also, we analyzed differences in brain natriuretic peptide (BNP) concentrations between diffuse cutaneous systemic sclerosis (DSSc) and limited cutaneous systemic sclerosis (LSSc) patients. DSSc patients had significantly higher concentrations of BNP. We found that levels of BNP were in significant positive correlations with age (p=0.007), disease duration (p=0.023), C reactive protein (CRP) (p=0.032), right ventricle fractional area change (FAC) (p=0.022), pulmonary vascular resistance (PVR) and Rodnan score (p=0.019). Conclusions: Given the obtained results, the laboratory determination of BNP could be useful in differentiating different forms of systemic sclerosis as well as in predicting the severity of the disease and future cardiovascular complications.
Кључне речи:
systemic sclerosis / right ventricle / right atrium / brain natriuretic peptide (BNP) / capillaroscopy / Rodnan scoreИзвор:
Journal of Medical Biochemistry, 2018, 37, 4, 406-414Издавач:
- Društvo medicinskih biohemičara Srbije, Beograd i Versita
DOI: 10.1515/jomb-2017-0058
ISSN: 1452-8258
PubMed: 30584399
WoS: 000442543800002
Scopus: 2-s2.0-85045840956
Институција/група
PharmacyTY - JOUR AU - Stefanović-Nešković, Jelena AU - Ristić, Andelka AU - Petronijević, Milan AU - Zeljković, Aleksandra AU - Grdinić, Aleksandra AU - Gudelj, Ognjen AU - Durović, Branka AU - Nesković, Branimir PY - 2018 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3075 AB - Background: Systemic sclerosis (SSc) is an autoimmune connective tissue disease which affects various tissues and organs, including skin, lungs, kidneys, gastrointestinal tract and cardiovascular system. Cardiac involvement is the most commonly recognized problem and a significant cause of morbidity. The brain natriuretic peptide (BNP) is a previously known marker of elevated cardiovascular risk in SSc, but the levels of BNP in various forms of SSc have not been investigated so far. Aim: The aim of our study was to evaluate the influence of SSc on the function of the right ventricle and the right atrium using the echocardiographic parameters. Moreover, we examined the levels of BNP in different forms of SSc as well as the association of disease severity with the plasma concentrations of BNP. Methods: We included 42 patients with newly diagnosed SSc and patients whose disease had been diagnosed earlier. SSc patients and non-SSc control patients were examined by using echocardiography and the concentrations of BNP were determined. Results: We analyzed differences in the parameters of right ventricle (RV) function and right atrium (RA) function between SSc patients and healthy controls. The two groups had similar distribution of gender, but SSc patients were significantly older than controls. RV wall thickness was increased in SSc patients (p lt 0.001), while right ventricular end-systolic area (RVEDA; p=0.408) and right ventricular end-diastolic area (RVEDA; p=0.368) did not differ among the examinees. In contrast, RA minor-axis dimension (p=0.001) and the tricuspid annular plane systolic excursion (TAPSE) (p=0.001) were significantly higher in SSc patients. Also, we analyzed differences in brain natriuretic peptide (BNP) concentrations between diffuse cutaneous systemic sclerosis (DSSc) and limited cutaneous systemic sclerosis (LSSc) patients. DSSc patients had significantly higher concentrations of BNP. We found that levels of BNP were in significant positive correlations with age (p=0.007), disease duration (p=0.023), C reactive protein (CRP) (p=0.032), right ventricle fractional area change (FAC) (p=0.022), pulmonary vascular resistance (PVR) and Rodnan score (p=0.019). Conclusions: Given the obtained results, the laboratory determination of BNP could be useful in differentiating different forms of systemic sclerosis as well as in predicting the severity of the disease and future cardiovascular complications. PB - Društvo medicinskih biohemičara Srbije, Beograd i Versita T2 - Journal of Medical Biochemistry T1 - B-Type Natriuretic Peptide as a Marker of Different Forms of Systemic Sclerosis VL - 37 IS - 4 SP - 406 EP - 414 DO - 10.1515/jomb-2017-0058 ER -
@article{ author = "Stefanović-Nešković, Jelena and Ristić, Andelka and Petronijević, Milan and Zeljković, Aleksandra and Grdinić, Aleksandra and Gudelj, Ognjen and Durović, Branka and Nesković, Branimir", year = "2018", abstract = "Background: Systemic sclerosis (SSc) is an autoimmune connective tissue disease which affects various tissues and organs, including skin, lungs, kidneys, gastrointestinal tract and cardiovascular system. Cardiac involvement is the most commonly recognized problem and a significant cause of morbidity. The brain natriuretic peptide (BNP) is a previously known marker of elevated cardiovascular risk in SSc, but the levels of BNP in various forms of SSc have not been investigated so far. Aim: The aim of our study was to evaluate the influence of SSc on the function of the right ventricle and the right atrium using the echocardiographic parameters. Moreover, we examined the levels of BNP in different forms of SSc as well as the association of disease severity with the plasma concentrations of BNP. Methods: We included 42 patients with newly diagnosed SSc and patients whose disease had been diagnosed earlier. SSc patients and non-SSc control patients were examined by using echocardiography and the concentrations of BNP were determined. Results: We analyzed differences in the parameters of right ventricle (RV) function and right atrium (RA) function between SSc patients and healthy controls. The two groups had similar distribution of gender, but SSc patients were significantly older than controls. RV wall thickness was increased in SSc patients (p lt 0.001), while right ventricular end-systolic area (RVEDA; p=0.408) and right ventricular end-diastolic area (RVEDA; p=0.368) did not differ among the examinees. In contrast, RA minor-axis dimension (p=0.001) and the tricuspid annular plane systolic excursion (TAPSE) (p=0.001) were significantly higher in SSc patients. Also, we analyzed differences in brain natriuretic peptide (BNP) concentrations between diffuse cutaneous systemic sclerosis (DSSc) and limited cutaneous systemic sclerosis (LSSc) patients. DSSc patients had significantly higher concentrations of BNP. We found that levels of BNP were in significant positive correlations with age (p=0.007), disease duration (p=0.023), C reactive protein (CRP) (p=0.032), right ventricle fractional area change (FAC) (p=0.022), pulmonary vascular resistance (PVR) and Rodnan score (p=0.019). Conclusions: Given the obtained results, the laboratory determination of BNP could be useful in differentiating different forms of systemic sclerosis as well as in predicting the severity of the disease and future cardiovascular complications.", publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita", journal = "Journal of Medical Biochemistry", title = "B-Type Natriuretic Peptide as a Marker of Different Forms of Systemic Sclerosis", volume = "37", number = "4", pages = "406-414", doi = "10.1515/jomb-2017-0058" }
Stefanović-Nešković, J., Ristić, A., Petronijević, M., Zeljković, A., Grdinić, A., Gudelj, O., Durović, B.,& Nesković, B.. (2018). B-Type Natriuretic Peptide as a Marker of Different Forms of Systemic Sclerosis. in Journal of Medical Biochemistry Društvo medicinskih biohemičara Srbije, Beograd i Versita., 37(4), 406-414. https://doi.org/10.1515/jomb-2017-0058
Stefanović-Nešković J, Ristić A, Petronijević M, Zeljković A, Grdinić A, Gudelj O, Durović B, Nesković B. B-Type Natriuretic Peptide as a Marker of Different Forms of Systemic Sclerosis. in Journal of Medical Biochemistry. 2018;37(4):406-414. doi:10.1515/jomb-2017-0058 .
Stefanović-Nešković, Jelena, Ristić, Andelka, Petronijević, Milan, Zeljković, Aleksandra, Grdinić, Aleksandra, Gudelj, Ognjen, Durović, Branka, Nesković, Branimir, "B-Type Natriuretic Peptide as a Marker of Different Forms of Systemic Sclerosis" in Journal of Medical Biochemistry, 37, no. 4 (2018):406-414, https://doi.org/10.1515/jomb-2017-0058 . .