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dc.creatorMilutinović, Violeta
dc.creatorNiketić, Marjan
dc.creatorKrunić, Aleksej
dc.creatorNikolić, Dejan
dc.creatorPetković, Miloš
dc.creatorUšjak, Ljuboš
dc.creatorPetrović, Silvana
dc.date.accessioned2019-09-02T12:04:10Z
dc.date.available2019-09-02T12:04:10Z
dc.date.issued2018
dc.identifier.issn0031-9422
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/3077
dc.description.abstractFour sesquiterpene lactones (SLs), including three undescribed proline-SL conjugates, the guaianolides calophyllamine A and 8-epiixerisamine A, and the eudesmanolide calophyllamine B, were isolated from the methanol extract of Hieracium calophyllum R. Uechtr. (Compositae) flowering heads. Another known guaianolide, crepiside E, was detected in Hieracium L. species for the first time. Their structures were elucidated using extensive 1D and 2D NMR spectroscopy in combination with HRMS. The isolated SLs were used as external standards for qualitative and quantitative LC-MS analysis of the dry methanol extracts of the flowering aerial parts of 28 Hieracium species from the Balkan Peninsula. Guaianolides were the dominant SLs in 27 species studied. The chemosystematic significance of detected SLs was evaluated using multivariate statistics (PCA, nMDS and UPGMA). Differentiation between the main groups was well supported. All four compounds significantly and equally contributed to the differences between the species. In addition, the eudesmanolide calophyllamine B could be a significant chemosystematic marker for H. sect. Villosa (Griseb.) Gremli s.l. and Glauciformia (Freyn) Zahn-Italica (Fr.) Av. Touv.en
dc.publisherPergamon-Elsevier Science Ltd, Oxford
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173021/RS//
dc.rightsrestrictedAccess
dc.sourcePhytochemistry
dc.subjectHieracium speciesen
dc.subjectCompositaeen
dc.subjectMethanol extractsen
dc.subjectProline-sesquiterpene lactone conjugatesen
dc.subjectNMRen
dc.subjectHRMSen
dc.subjectLC-MSen
dc.subjectChemosystematicen
dc.subjectStatistical analysisen
dc.titleSesquiterpene lactones from the methanol extracts of twenty-eight Hieracium species from the Balkan Peninsula and their chemosystematic significanceen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractПетковић, Милош; Крунић, Aлексеј; Никетић, Марјан; Милутиновић, Виолета; Петровић, Силвана; Николић, Дејан; Ушјак, Љубош;
dc.citation.volume154
dc.citation.spage19
dc.citation.epage30
dc.citation.other154: 19-30
dc.citation.rankM21
dc.identifier.wos000443662400003
dc.identifier.doi10.1016/j.phytochem.2018.06.008
dc.identifier.pmid29935428
dc.identifier.scopus2-s2.0-85048732880
dc.identifier.rcubconv_4209
dc.type.versionpublishedVersion


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