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Associations of lipoprotein subclasses and oxidative stress status in pulmonary and pulmonary plus extrapulmonary sarcoidosis

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Authors
Ivanišević, Jasmina
Vekić, Jelena
Zeljković, Aleksandra
Stefanović, Aleksandra
Kotur-Stevuljević, Jelena
Spasojević-Kalimanovska, Vesna
Spasić, Slavica
Vučinić-Mihailović, Violeta
Videnović-Ivanov, Jelica
Jelić-Ivanović, Zorana
Article (Published version)
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Abstract
Background: Sarcoidosis is an inflammatory disease with pulmonary and extrapulmonary manifestations. In such pathologic conditions, increased oxidative stress and rearrangement of high-density lipoprotein (HDL) and low-density lipoprotein (LDL) may occur. Objective: This study evaluated association of oxidative stress and lipoprotein subclasses in severe forms of pulmonary and pulmonary plus extrapulmonary sarcoidosis. Methods: Lipid parameters, LDL and HDL subclass distributions, high-sensitivity C-reactive protein (hsCRP), serum amyloid A (SAA), paraoxonase 1 (PON1), malondialdehyde (MDA), total-oxidant status (TOS), sulfhydryl (SH) groups, pro-oxidant anti-oxidant balance (PAB) were determined in 77 patients (53 isolated pulmonary and 24 pulmonary plus extrapulmonary) and 139 controls. Results: Both pulmonary and extrapulmonary sarcoidosis patients had significantly higher levels of triglycerides and TOS (P lt 0.05) and more LDL II, LDL III, LDL IVA particles (P lt 0.01), but lower ...HDL size, SH groups (P lt 0.001), PON1 activity and less LDL I subclasses (P lt 0.05) than controls. In isolated pulmonary disease, HDL-cholesterol (P lt 0.01) was significantly lower whereas proportions of HDL 3a and PAB were significantly higher (P lt 0.05) when compared with the control group. PON1 was significantly higher in pulmonary than in combined pulmonary-extrapulmonary disease (P lt 0.05). In pulmonary sarcoidosis, TOS and PON1 correlated significantly with small-sized HDL particles (P lt 0.05). Conclusions: Both patient groups were characterized by adverse lipoprotein profile and elevated oxidative stress. In isolated pulmonary group significant associations of oxidative stress and HDL particles distribution was demonstrated. Pulmonary sarcoidosis was associated with higher PON1 activity and rearrangement of LDL particles did not depend on disease localization.

Keywords:
lipoproteins / oxidative stress / paraoxonase-1 / sarcoidosis manifestations
Source:
Sarcoidosis Vasculitis and Diffuse Lung Diseases, 2018, 35, 3, 198-205
Publisher:
  • Mattioli 1885, Fidenza
Projects:
  • Interactive role of dyslipidemia, oxidative stress and inflammation in atherosclerosis and other diseases: genetic and biochemical markers (RS-175035)

ISSN: 1124-0490

WoS: 000447628600003

Scopus: 2-s2.0-85055276679
[ Google Scholar ]
2
2
URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/3078
Collections
  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy
TY  - JOUR
AU  - Ivanišević, Jasmina
AU  - Vekić, Jelena
AU  - Zeljković, Aleksandra
AU  - Stefanović, Aleksandra
AU  - Kotur-Stevuljević, Jelena
AU  - Spasojević-Kalimanovska, Vesna
AU  - Spasić, Slavica
AU  - Vučinić-Mihailović, Violeta
AU  - Videnović-Ivanov, Jelica
AU  - Jelić-Ivanović, Zorana
PY  - 2018
UR  - http://farfar.pharmacy.bg.ac.rs/handle/123456789/3078
AB  - Background: Sarcoidosis is an inflammatory disease with pulmonary and extrapulmonary manifestations. In such pathologic conditions, increased oxidative stress and rearrangement of high-density lipoprotein (HDL) and low-density lipoprotein (LDL) may occur. Objective: This study evaluated association of oxidative stress and lipoprotein subclasses in severe forms of pulmonary and pulmonary plus extrapulmonary sarcoidosis. Methods: Lipid parameters, LDL and HDL subclass distributions, high-sensitivity C-reactive protein (hsCRP), serum amyloid A (SAA), paraoxonase 1 (PON1), malondialdehyde (MDA), total-oxidant status (TOS), sulfhydryl (SH) groups, pro-oxidant anti-oxidant balance (PAB) were determined in 77 patients (53 isolated pulmonary and 24 pulmonary plus extrapulmonary) and 139 controls. Results: Both pulmonary and extrapulmonary sarcoidosis patients had significantly higher levels of triglycerides and TOS (P lt 0.05) and more LDL II, LDL III, LDL IVA particles (P lt 0.01), but lower HDL size, SH groups (P lt 0.001), PON1 activity and less LDL I subclasses (P lt 0.05) than controls. In isolated pulmonary disease, HDL-cholesterol (P lt 0.01) was significantly lower whereas proportions of HDL 3a and PAB were significantly higher (P lt 0.05) when compared with the control group. PON1 was significantly higher in pulmonary than in combined pulmonary-extrapulmonary disease (P lt 0.05). In pulmonary sarcoidosis, TOS and PON1 correlated significantly with small-sized HDL particles (P lt 0.05). Conclusions: Both patient groups were characterized by adverse lipoprotein profile and elevated oxidative stress. In isolated pulmonary group significant associations of oxidative stress and HDL particles distribution was demonstrated. Pulmonary sarcoidosis was associated with higher PON1 activity and rearrangement of LDL particles did not depend on disease localization.
PB  - Mattioli 1885, Fidenza
T2  - Sarcoidosis Vasculitis and Diffuse Lung Diseases
T1  - Associations of lipoprotein subclasses and oxidative stress status in pulmonary and pulmonary plus extrapulmonary sarcoidosis
VL  - 35
IS  - 3
SP  - 198
EP  - 205
ER  - 
@article{
author = "Ivanišević, Jasmina and Vekić, Jelena and Zeljković, Aleksandra and Stefanović, Aleksandra and Kotur-Stevuljević, Jelena and Spasojević-Kalimanovska, Vesna and Spasić, Slavica and Vučinić-Mihailović, Violeta and Videnović-Ivanov, Jelica and Jelić-Ivanović, Zorana",
year = "2018",
url = "http://farfar.pharmacy.bg.ac.rs/handle/123456789/3078",
abstract = "Background: Sarcoidosis is an inflammatory disease with pulmonary and extrapulmonary manifestations. In such pathologic conditions, increased oxidative stress and rearrangement of high-density lipoprotein (HDL) and low-density lipoprotein (LDL) may occur. Objective: This study evaluated association of oxidative stress and lipoprotein subclasses in severe forms of pulmonary and pulmonary plus extrapulmonary sarcoidosis. Methods: Lipid parameters, LDL and HDL subclass distributions, high-sensitivity C-reactive protein (hsCRP), serum amyloid A (SAA), paraoxonase 1 (PON1), malondialdehyde (MDA), total-oxidant status (TOS), sulfhydryl (SH) groups, pro-oxidant anti-oxidant balance (PAB) were determined in 77 patients (53 isolated pulmonary and 24 pulmonary plus extrapulmonary) and 139 controls. Results: Both pulmonary and extrapulmonary sarcoidosis patients had significantly higher levels of triglycerides and TOS (P lt 0.05) and more LDL II, LDL III, LDL IVA particles (P lt 0.01), but lower HDL size, SH groups (P lt 0.001), PON1 activity and less LDL I subclasses (P lt 0.05) than controls. In isolated pulmonary disease, HDL-cholesterol (P lt 0.01) was significantly lower whereas proportions of HDL 3a and PAB were significantly higher (P lt 0.05) when compared with the control group. PON1 was significantly higher in pulmonary than in combined pulmonary-extrapulmonary disease (P lt 0.05). In pulmonary sarcoidosis, TOS and PON1 correlated significantly with small-sized HDL particles (P lt 0.05). Conclusions: Both patient groups were characterized by adverse lipoprotein profile and elevated oxidative stress. In isolated pulmonary group significant associations of oxidative stress and HDL particles distribution was demonstrated. Pulmonary sarcoidosis was associated with higher PON1 activity and rearrangement of LDL particles did not depend on disease localization.",
publisher = "Mattioli 1885, Fidenza",
journal = "Sarcoidosis Vasculitis and Diffuse Lung Diseases",
title = "Associations of lipoprotein subclasses and oxidative stress status in pulmonary and pulmonary plus extrapulmonary sarcoidosis",
volume = "35",
number = "3",
pages = "198-205"
}
Ivanišević J, Vekić J, Zeljković A, Stefanović A, Kotur-Stevuljević J, Spasojević-Kalimanovska V, Spasić S, Vučinić-Mihailović V, Videnović-Ivanov J, Jelić-Ivanović Z. Associations of lipoprotein subclasses and oxidative stress status in pulmonary and pulmonary plus extrapulmonary sarcoidosis. Sarcoidosis Vasculitis and Diffuse Lung Diseases. 2018;35(3):198-205
Ivanišević, J., Vekić, J., Zeljković, A., Stefanović, A., Kotur-Stevuljević, J., Spasojević-Kalimanovska, V., Spasić, S., Vučinić-Mihailović, V., Videnović-Ivanov, J.,& Jelić-Ivanović, Z. (2018). Associations of lipoprotein subclasses and oxidative stress status in pulmonary and pulmonary plus extrapulmonary sarcoidosis.
Sarcoidosis Vasculitis and Diffuse Lung DiseasesMattioli 1885, Fidenza., 35(3), 198-205.
Ivanišević Jasmina, Vekić Jelena, Zeljković Aleksandra, Stefanović Aleksandra, Kotur-Stevuljević Jelena, Spasojević-Kalimanovska Vesna, Spasić Slavica, Vučinić-Mihailović Violeta, Videnović-Ivanov Jelica, Jelić-Ivanović Zorana, "Associations of lipoprotein subclasses and oxidative stress status in pulmonary and pulmonary plus extrapulmonary sarcoidosis" 35, no. 3 (2018):198-205

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