Associations of lipoprotein subclasses and oxidative stress status in pulmonary and pulmonary plus extrapulmonary sarcoidosis
Authors
Ivanišević, Jasmina
Vekić, Jelena

Zeljković, Aleksandra

Stefanović, Aleksandra

Kotur-Stevuljević, Jelena

Spasojević-Kalimanovska, Vesna

Spasić, Slavica
Vučinić-Mihailović, Violeta
Videnović-Ivanov, Jelica
Jelić-Ivanović, Zorana

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Background: Sarcoidosis is an inflammatory disease with pulmonary and extrapulmonary manifestations. In such pathologic conditions, increased oxidative stress and rearrangement of high-density lipoprotein (HDL) and low-density lipoprotein (LDL) may occur. Objective: This study evaluated association of oxidative stress and lipoprotein subclasses in severe forms of pulmonary and pulmonary plus extrapulmonary sarcoidosis. Methods: Lipid parameters, LDL and HDL subclass distributions, high-sensitivity C-reactive protein (hsCRP), serum amyloid A (SAA), paraoxonase 1 (PON1), malondialdehyde (MDA), total-oxidant status (TOS), sulfhydryl (SH) groups, pro-oxidant anti-oxidant balance (PAB) were determined in 77 patients (53 isolated pulmonary and 24 pulmonary plus extrapulmonary) and 139 controls. Results: Both pulmonary and extrapulmonary sarcoidosis patients had significantly higher levels of triglycerides and TOS (P lt 0.05) and more LDL II, LDL III, LDL IVA particles (P lt 0.01), but lower ...HDL size, SH groups (P lt 0.001), PON1 activity and less LDL I subclasses (P lt 0.05) than controls. In isolated pulmonary disease, HDL-cholesterol (P lt 0.01) was significantly lower whereas proportions of HDL 3a and PAB were significantly higher (P lt 0.05) when compared with the control group. PON1 was significantly higher in pulmonary than in combined pulmonary-extrapulmonary disease (P lt 0.05). In pulmonary sarcoidosis, TOS and PON1 correlated significantly with small-sized HDL particles (P lt 0.05). Conclusions: Both patient groups were characterized by adverse lipoprotein profile and elevated oxidative stress. In isolated pulmonary group significant associations of oxidative stress and HDL particles distribution was demonstrated. Pulmonary sarcoidosis was associated with higher PON1 activity and rearrangement of LDL particles did not depend on disease localization.
Keywords:
lipoproteins / oxidative stress / paraoxonase-1 / sarcoidosis manifestationsSource:
Sarcoidosis Vasculitis and Diffuse Lung Diseases, 2018, 35, 3, 198-205Publisher:
- Mattioli 1885, Fidenza
Funding / projects:
DOI: 10.36141/svdld.v35i3.6573
ISSN: 1124-0490
WoS: 000447628600003
Scopus: 2-s2.0-85055276679
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PharmacyTY - JOUR AU - Ivanišević, Jasmina AU - Vekić, Jelena AU - Zeljković, Aleksandra AU - Stefanović, Aleksandra AU - Kotur-Stevuljević, Jelena AU - Spasojević-Kalimanovska, Vesna AU - Spasić, Slavica AU - Vučinić-Mihailović, Violeta AU - Videnović-Ivanov, Jelica AU - Jelić-Ivanović, Zorana PY - 2018 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3078 AB - Background: Sarcoidosis is an inflammatory disease with pulmonary and extrapulmonary manifestations. In such pathologic conditions, increased oxidative stress and rearrangement of high-density lipoprotein (HDL) and low-density lipoprotein (LDL) may occur. Objective: This study evaluated association of oxidative stress and lipoprotein subclasses in severe forms of pulmonary and pulmonary plus extrapulmonary sarcoidosis. Methods: Lipid parameters, LDL and HDL subclass distributions, high-sensitivity C-reactive protein (hsCRP), serum amyloid A (SAA), paraoxonase 1 (PON1), malondialdehyde (MDA), total-oxidant status (TOS), sulfhydryl (SH) groups, pro-oxidant anti-oxidant balance (PAB) were determined in 77 patients (53 isolated pulmonary and 24 pulmonary plus extrapulmonary) and 139 controls. Results: Both pulmonary and extrapulmonary sarcoidosis patients had significantly higher levels of triglycerides and TOS (P lt 0.05) and more LDL II, LDL III, LDL IVA particles (P lt 0.01), but lower HDL size, SH groups (P lt 0.001), PON1 activity and less LDL I subclasses (P lt 0.05) than controls. In isolated pulmonary disease, HDL-cholesterol (P lt 0.01) was significantly lower whereas proportions of HDL 3a and PAB were significantly higher (P lt 0.05) when compared with the control group. PON1 was significantly higher in pulmonary than in combined pulmonary-extrapulmonary disease (P lt 0.05). In pulmonary sarcoidosis, TOS and PON1 correlated significantly with small-sized HDL particles (P lt 0.05). Conclusions: Both patient groups were characterized by adverse lipoprotein profile and elevated oxidative stress. In isolated pulmonary group significant associations of oxidative stress and HDL particles distribution was demonstrated. Pulmonary sarcoidosis was associated with higher PON1 activity and rearrangement of LDL particles did not depend on disease localization. PB - Mattioli 1885, Fidenza T2 - Sarcoidosis Vasculitis and Diffuse Lung Diseases T1 - Associations of lipoprotein subclasses and oxidative stress status in pulmonary and pulmonary plus extrapulmonary sarcoidosis VL - 35 IS - 3 SP - 198 EP - 205 DO - 10.36141/svdld.v35i3.6573 UR - https://hdl.handle.net/21.15107/rcub_farfar_3078 ER -
@article{ author = "Ivanišević, Jasmina and Vekić, Jelena and Zeljković, Aleksandra and Stefanović, Aleksandra and Kotur-Stevuljević, Jelena and Spasojević-Kalimanovska, Vesna and Spasić, Slavica and Vučinić-Mihailović, Violeta and Videnović-Ivanov, Jelica and Jelić-Ivanović, Zorana", year = "2018", abstract = "Background: Sarcoidosis is an inflammatory disease with pulmonary and extrapulmonary manifestations. In such pathologic conditions, increased oxidative stress and rearrangement of high-density lipoprotein (HDL) and low-density lipoprotein (LDL) may occur. Objective: This study evaluated association of oxidative stress and lipoprotein subclasses in severe forms of pulmonary and pulmonary plus extrapulmonary sarcoidosis. Methods: Lipid parameters, LDL and HDL subclass distributions, high-sensitivity C-reactive protein (hsCRP), serum amyloid A (SAA), paraoxonase 1 (PON1), malondialdehyde (MDA), total-oxidant status (TOS), sulfhydryl (SH) groups, pro-oxidant anti-oxidant balance (PAB) were determined in 77 patients (53 isolated pulmonary and 24 pulmonary plus extrapulmonary) and 139 controls. Results: Both pulmonary and extrapulmonary sarcoidosis patients had significantly higher levels of triglycerides and TOS (P lt 0.05) and more LDL II, LDL III, LDL IVA particles (P lt 0.01), but lower HDL size, SH groups (P lt 0.001), PON1 activity and less LDL I subclasses (P lt 0.05) than controls. In isolated pulmonary disease, HDL-cholesterol (P lt 0.01) was significantly lower whereas proportions of HDL 3a and PAB were significantly higher (P lt 0.05) when compared with the control group. PON1 was significantly higher in pulmonary than in combined pulmonary-extrapulmonary disease (P lt 0.05). In pulmonary sarcoidosis, TOS and PON1 correlated significantly with small-sized HDL particles (P lt 0.05). Conclusions: Both patient groups were characterized by adverse lipoprotein profile and elevated oxidative stress. In isolated pulmonary group significant associations of oxidative stress and HDL particles distribution was demonstrated. Pulmonary sarcoidosis was associated with higher PON1 activity and rearrangement of LDL particles did not depend on disease localization.", publisher = "Mattioli 1885, Fidenza", journal = "Sarcoidosis Vasculitis and Diffuse Lung Diseases", title = "Associations of lipoprotein subclasses and oxidative stress status in pulmonary and pulmonary plus extrapulmonary sarcoidosis", volume = "35", number = "3", pages = "198-205", doi = "10.36141/svdld.v35i3.6573", url = "https://hdl.handle.net/21.15107/rcub_farfar_3078" }
Ivanišević, J., Vekić, J., Zeljković, A., Stefanović, A., Kotur-Stevuljević, J., Spasojević-Kalimanovska, V., Spasić, S., Vučinić-Mihailović, V., Videnović-Ivanov, J.,& Jelić-Ivanović, Z.. (2018). Associations of lipoprotein subclasses and oxidative stress status in pulmonary and pulmonary plus extrapulmonary sarcoidosis. in Sarcoidosis Vasculitis and Diffuse Lung Diseases Mattioli 1885, Fidenza., 35(3), 198-205. https://doi.org/10.36141/svdld.v35i3.6573 https://hdl.handle.net/21.15107/rcub_farfar_3078
Ivanišević J, Vekić J, Zeljković A, Stefanović A, Kotur-Stevuljević J, Spasojević-Kalimanovska V, Spasić S, Vučinić-Mihailović V, Videnović-Ivanov J, Jelić-Ivanović Z. Associations of lipoprotein subclasses and oxidative stress status in pulmonary and pulmonary plus extrapulmonary sarcoidosis. in Sarcoidosis Vasculitis and Diffuse Lung Diseases. 2018;35(3):198-205. doi:10.36141/svdld.v35i3.6573 https://hdl.handle.net/21.15107/rcub_farfar_3078 .
Ivanišević, Jasmina, Vekić, Jelena, Zeljković, Aleksandra, Stefanović, Aleksandra, Kotur-Stevuljević, Jelena, Spasojević-Kalimanovska, Vesna, Spasić, Slavica, Vučinić-Mihailović, Violeta, Videnović-Ivanov, Jelica, Jelić-Ivanović, Zorana, "Associations of lipoprotein subclasses and oxidative stress status in pulmonary and pulmonary plus extrapulmonary sarcoidosis" in Sarcoidosis Vasculitis and Diffuse Lung Diseases, 35, no. 3 (2018):198-205, https://doi.org/10.36141/svdld.v35i3.6573 ., https://hdl.handle.net/21.15107/rcub_farfar_3078 .