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dc.creatorIvanišević, Jasmina
dc.creatorVekić, Jelena
dc.creatorZeljković, Aleksandra
dc.creatorStefanović, Aleksandra
dc.creatorKotur-Stevuljević, Jelena
dc.creatorSpasojević-Kalimanovska, Vesna
dc.creatorSpasić, Slavica
dc.creatorVučinić-Mihailović, Violeta
dc.creatorVidenović-Ivanov, Jelica
dc.creatorJelić-Ivanović, Zorana
dc.date.accessioned2019-09-02T12:04:14Z
dc.date.available2019-09-02T12:04:14Z
dc.date.issued2018
dc.identifier.issn1124-0490
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/3078
dc.description.abstractBackground: Sarcoidosis is an inflammatory disease with pulmonary and extrapulmonary manifestations. In such pathologic conditions, increased oxidative stress and rearrangement of high-density lipoprotein (HDL) and low-density lipoprotein (LDL) may occur. Objective: This study evaluated association of oxidative stress and lipoprotein subclasses in severe forms of pulmonary and pulmonary plus extrapulmonary sarcoidosis. Methods: Lipid parameters, LDL and HDL subclass distributions, high-sensitivity C-reactive protein (hsCRP), serum amyloid A (SAA), paraoxonase 1 (PON1), malondialdehyde (MDA), total-oxidant status (TOS), sulfhydryl (SH) groups, pro-oxidant anti-oxidant balance (PAB) were determined in 77 patients (53 isolated pulmonary and 24 pulmonary plus extrapulmonary) and 139 controls. Results: Both pulmonary and extrapulmonary sarcoidosis patients had significantly higher levels of triglycerides and TOS (P lt 0.05) and more LDL II, LDL III, LDL IVA particles (P lt 0.01), but lower HDL size, SH groups (P lt 0.001), PON1 activity and less LDL I subclasses (P lt 0.05) than controls. In isolated pulmonary disease, HDL-cholesterol (P lt 0.01) was significantly lower whereas proportions of HDL 3a and PAB were significantly higher (P lt 0.05) when compared with the control group. PON1 was significantly higher in pulmonary than in combined pulmonary-extrapulmonary disease (P lt 0.05). In pulmonary sarcoidosis, TOS and PON1 correlated significantly with small-sized HDL particles (P lt 0.05). Conclusions: Both patient groups were characterized by adverse lipoprotein profile and elevated oxidative stress. In isolated pulmonary group significant associations of oxidative stress and HDL particles distribution was demonstrated. Pulmonary sarcoidosis was associated with higher PON1 activity and rearrangement of LDL particles did not depend on disease localization.en
dc.publisherMattioli 1885, Fidenza
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175035/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.sourceSarcoidosis Vasculitis and Diffuse Lung Diseases
dc.subjectlipoproteinsen
dc.subjectoxidative stressen
dc.subjectparaoxonase-1en
dc.subjectsarcoidosis manifestationsen
dc.titleAssociations of lipoprotein subclasses and oxidative stress status in pulmonary and pulmonary plus extrapulmonary sarcoidosisen
dc.typearticle
dc.rights.licenseBY-NC
dcterms.abstractИванишевић, Јасмина; Спасић, Славица; Виденовић-Иванов, Јелица; Вучинић-Михаиловић, Виолета; Векић, Јелена; Стефановић, Aлександра; Зељковић, Aлександра; Котур-Стевуљевић, Јелена; Спасојевић-Калимановска, Весна; Јелић-Ивановић, Зорана;
dc.citation.volume35
dc.citation.issue3
dc.citation.spage198
dc.citation.epage205
dc.citation.other35(3): 198-205
dc.citation.rankM23
dc.identifier.wos000447628600003
dc.identifier.doi10.36141/svdld.v35i3.6573
dc.identifier.scopus2-s2.0-85055276679
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs/bitstream/id/11574/Associations_of_lipoprotein_pub_2018.pdf
dc.identifier.rcubhttps://hdl.handle.net/21.15107/rcub_farfar_3078
dc.type.versionpublishedVersion


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