Thin-layer chromatography of several antihypertensive drugs from the group of angiotensin converting enzyme inhibitors
Tankoslojna hromatografija nekih antihipertenziva iz grupe angiotenzin konvertujućih enzim inhibitora

2001
Authors
Aleksić, MirjanaAgbaba, Danica

Baošić, Rada M.
Milojković-Opsenica, Dušanka

Tešić, Živoslav

Article (Published version)
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A rapid and simple method for the chromatographic separation of pharmacologically active components contained in some antihypertensive drugs has been developed employing thin-layers of silica gel and polyacrylonitrile sorbent (PANS). The active compounds of Captopril - (S)-1-(3-mercapto-2- methyl-1-oxopropyl)-L-proline, Enalapril - (S)-1-[N-[1-(ethoxycarbonyl)-3- phenylpropyl]-L-alanyl]-L-proline, Lisinopril - (S) -1-[N2-(carboxy-3- phenylpropyl)-L-lysyl]-L-proline, Quinapril - [3S-[2[R*(R*)],3R*]],-2-[2-[[1 (-ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-3- iso-quinoline-carboxylic acid, Ramipril - [2S-[1[R*(R*)],2α,3αβ,6αβ]]-1-[2[[ 1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydrocyclopenta[β]- pyrole-2-carboxylic acid and Cilazapril - [1S-[1α,9α(R*)]]-9-[[1- (ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-6H-pyridazino[1,2-α] [1,2]diazepine-1-carboxylic acid, were successfully separated by the presented procedures. For their chromatographi...c separation on silica gel sixteen and on PANS thirteen solvents were used.
U radu je u uslovima hromatografije na tankim slojevima silika-gela i poliakrilonitrilnog sorbenta (PANS-a), izvršeno razdvajanje sledećih antihipertenziva iz grupe angiotenzin konvertujućih enzim inhibitora (ACE inhibitora): Kaptopril-a, Enalapril-a, Lizinopril-a, Kvinapril-a, Ramipril-a, Cilazapril-a. Za njihovo hromatografsko razdvajanje upotrebljeni su mnogi rastvarači. Na osnovu dobijenih rezultata diskutovani su mehanizmi odvajanja. Na taj način data je jedna veoma brza i jednostavna metoda za odvajanje pomenutih supstanci.
Keywords:
thin-layer chromatography / silica gel / polyacrylonitrile sorbent / antihypertensive drugs / angiotensin converting enzyme inhibitorsSource:
Journal of the Serbian Chemical Society, 2001, 66, 1, 39-44Publisher:
- Srpsko hemijsko društvo, Beograd
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PharmacyTY - JOUR AU - Aleksić, Mirjana AU - Agbaba, Danica AU - Baošić, Rada M. AU - Milojković-Opsenica, Dušanka AU - Tešić, Živoslav PY - 2001 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/308 AB - A rapid and simple method for the chromatographic separation of pharmacologically active components contained in some antihypertensive drugs has been developed employing thin-layers of silica gel and polyacrylonitrile sorbent (PANS). The active compounds of Captopril - (S)-1-(3-mercapto-2- methyl-1-oxopropyl)-L-proline, Enalapril - (S)-1-[N-[1-(ethoxycarbonyl)-3- phenylpropyl]-L-alanyl]-L-proline, Lisinopril - (S) -1-[N2-(carboxy-3- phenylpropyl)-L-lysyl]-L-proline, Quinapril - [3S-[2[R*(R*)],3R*]],-2-[2-[[1 (-ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-3- iso-quinoline-carboxylic acid, Ramipril - [2S-[1[R*(R*)],2α,3αβ,6αβ]]-1-[2[[ 1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydrocyclopenta[β]- pyrole-2-carboxylic acid and Cilazapril - [1S-[1α,9α(R*)]]-9-[[1- (ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-6H-pyridazino[1,2-α] [1,2]diazepine-1-carboxylic acid, were successfully separated by the presented procedures. For their chromatographic separation on silica gel sixteen and on PANS thirteen solvents were used. AB - U radu je u uslovima hromatografije na tankim slojevima silika-gela i poliakrilonitrilnog sorbenta (PANS-a), izvršeno razdvajanje sledećih antihipertenziva iz grupe angiotenzin konvertujućih enzim inhibitora (ACE inhibitora): Kaptopril-a, Enalapril-a, Lizinopril-a, Kvinapril-a, Ramipril-a, Cilazapril-a. Za njihovo hromatografsko razdvajanje upotrebljeni su mnogi rastvarači. Na osnovu dobijenih rezultata diskutovani su mehanizmi odvajanja. Na taj način data je jedna veoma brza i jednostavna metoda za odvajanje pomenutih supstanci. PB - Srpsko hemijsko društvo, Beograd T2 - Journal of the Serbian Chemical Society T1 - Thin-layer chromatography of several antihypertensive drugs from the group of angiotensin converting enzyme inhibitors T1 - Tankoslojna hromatografija nekih antihipertenziva iz grupe angiotenzin konvertujućih enzim inhibitora VL - 66 IS - 1 SP - 39 EP - 44 UR - https://hdl.handle.net/21.15107/rcub_farfar_308 ER -
@article{ author = "Aleksić, Mirjana and Agbaba, Danica and Baošić, Rada M. and Milojković-Opsenica, Dušanka and Tešić, Živoslav", year = "2001", abstract = "A rapid and simple method for the chromatographic separation of pharmacologically active components contained in some antihypertensive drugs has been developed employing thin-layers of silica gel and polyacrylonitrile sorbent (PANS). The active compounds of Captopril - (S)-1-(3-mercapto-2- methyl-1-oxopropyl)-L-proline, Enalapril - (S)-1-[N-[1-(ethoxycarbonyl)-3- phenylpropyl]-L-alanyl]-L-proline, Lisinopril - (S) -1-[N2-(carboxy-3- phenylpropyl)-L-lysyl]-L-proline, Quinapril - [3S-[2[R*(R*)],3R*]],-2-[2-[[1 (-ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-3- iso-quinoline-carboxylic acid, Ramipril - [2S-[1[R*(R*)],2α,3αβ,6αβ]]-1-[2[[ 1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydrocyclopenta[β]- pyrole-2-carboxylic acid and Cilazapril - [1S-[1α,9α(R*)]]-9-[[1- (ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-6H-pyridazino[1,2-α] [1,2]diazepine-1-carboxylic acid, were successfully separated by the presented procedures. For their chromatographic separation on silica gel sixteen and on PANS thirteen solvents were used., U radu je u uslovima hromatografije na tankim slojevima silika-gela i poliakrilonitrilnog sorbenta (PANS-a), izvršeno razdvajanje sledećih antihipertenziva iz grupe angiotenzin konvertujućih enzim inhibitora (ACE inhibitora): Kaptopril-a, Enalapril-a, Lizinopril-a, Kvinapril-a, Ramipril-a, Cilazapril-a. Za njihovo hromatografsko razdvajanje upotrebljeni su mnogi rastvarači. Na osnovu dobijenih rezultata diskutovani su mehanizmi odvajanja. Na taj način data je jedna veoma brza i jednostavna metoda za odvajanje pomenutih supstanci.", publisher = "Srpsko hemijsko društvo, Beograd", journal = "Journal of the Serbian Chemical Society", title = "Thin-layer chromatography of several antihypertensive drugs from the group of angiotensin converting enzyme inhibitors, Tankoslojna hromatografija nekih antihipertenziva iz grupe angiotenzin konvertujućih enzim inhibitora", volume = "66", number = "1", pages = "39-44", url = "https://hdl.handle.net/21.15107/rcub_farfar_308" }
Aleksić, M., Agbaba, D., Baošić, R. M., Milojković-Opsenica, D.,& Tešić, Ž.. (2001). Thin-layer chromatography of several antihypertensive drugs from the group of angiotensin converting enzyme inhibitors. in Journal of the Serbian Chemical Society Srpsko hemijsko društvo, Beograd., 66(1), 39-44. https://hdl.handle.net/21.15107/rcub_farfar_308
Aleksić M, Agbaba D, Baošić RM, Milojković-Opsenica D, Tešić Ž. Thin-layer chromatography of several antihypertensive drugs from the group of angiotensin converting enzyme inhibitors. in Journal of the Serbian Chemical Society. 2001;66(1):39-44. https://hdl.handle.net/21.15107/rcub_farfar_308 .
Aleksić, Mirjana, Agbaba, Danica, Baošić, Rada M., Milojković-Opsenica, Dušanka, Tešić, Živoslav, "Thin-layer chromatography of several antihypertensive drugs from the group of angiotensin converting enzyme inhibitors" in Journal of the Serbian Chemical Society, 66, no. 1 (2001):39-44, https://hdl.handle.net/21.15107/rcub_farfar_308 .