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Thin-layer chromatography of several antihypertensive drugs from the group of angiotensin converting enzyme inhibitors

Tankoslojna hromatografija nekih antihipertenziva iz grupe angiotenzin konvertujućih enzim inhibitora

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2001
306.pdf (78.52Kb)
Authors
Aleksić, Mirjana
Agbaba, Danica
Baošić, Rada M.
Milojković-Opsenica, Dušanka
Tešić, Živoslav
Article (Published version)
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Abstract
A rapid and simple method for the chromatographic separation of pharmacologically active components contained in some antihypertensive drugs has been developed employing thin-layers of silica gel and polyacrylonitrile sorbent (PANS). The active compounds of Captopril - (S)-1-(3-mercapto-2- methyl-1-oxopropyl)-L-proline, Enalapril - (S)-1-[N-[1-(ethoxycarbonyl)-3- phenylpropyl]-L-alanyl]-L-proline, Lisinopril - (S) -1-[N2-(carboxy-3- phenylpropyl)-L-lysyl]-L-proline, Quinapril - [3S-[2[R*(R*)],3R*]],-2-[2-[[1 (-ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-3- iso-quinoline-carboxylic acid, Ramipril - [2S-[1[R*(R*)],2α,3αβ,6αβ]]-1-[2[[ 1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydrocyclopenta[β]- pyrole-2-carboxylic acid and Cilazapril - [1S-[1α,9α(R*)]]-9-[[1- (ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-6H-pyridazino[1,2-α] [1,2]diazepine-1-carboxylic acid, were successfully separated by the presented procedures. For their chromatographi...c separation on silica gel sixteen and on PANS thirteen solvents were used.

U radu je u uslovima hromatografije na tankim slojevima silika-gela i poliakrilonitrilnog sorbenta (PANS-a), izvršeno razdvajanje sledećih antihipertenziva iz grupe angiotenzin konvertujućih enzim inhibitora (ACE inhibitora): Kaptopril-a, Enalapril-a, Lizinopril-a, Kvinapril-a, Ramipril-a, Cilazapril-a. Za njihovo hromatografsko razdvajanje upotrebljeni su mnogi rastvarači. Na osnovu dobijenih rezultata diskutovani su mehanizmi odvajanja. Na taj način data je jedna veoma brza i jednostavna metoda za odvajanje pomenutih supstanci.
Keywords:
thin-layer chromatography / silica gel / polyacrylonitrile sorbent / antihypertensive drugs / angiotensin converting enzyme inhibitors
Source:
Journal of the Serbian Chemical Society, 2001, 66, 1, 39-44
Publisher:
  • Srpsko hemijsko društvo, Beograd

ISSN: 0352-5139

WoS: 000166757200006

Scopus: 2-s2.0-5844370750
[ Google Scholar ]
10
8
Handle
https://hdl.handle.net/21.15107/rcub_farfar_308
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/308
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Aleksić, Mirjana
AU  - Agbaba, Danica
AU  - Baošić, Rada M.
AU  - Milojković-Opsenica, Dušanka
AU  - Tešić, Živoslav
PY  - 2001
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/308
AB  - A rapid and simple method for the chromatographic separation of pharmacologically active components contained in some antihypertensive drugs has been developed employing thin-layers of silica gel and polyacrylonitrile sorbent (PANS). The active compounds of Captopril - (S)-1-(3-mercapto-2- methyl-1-oxopropyl)-L-proline, Enalapril - (S)-1-[N-[1-(ethoxycarbonyl)-3- phenylpropyl]-L-alanyl]-L-proline, Lisinopril - (S) -1-[N2-(carboxy-3- phenylpropyl)-L-lysyl]-L-proline, Quinapril - [3S-[2[R*(R*)],3R*]],-2-[2-[[1 (-ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-3- iso-quinoline-carboxylic acid, Ramipril - [2S-[1[R*(R*)],2α,3αβ,6αβ]]-1-[2[[ 1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydrocyclopenta[β]- pyrole-2-carboxylic acid and Cilazapril - [1S-[1α,9α(R*)]]-9-[[1- (ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-6H-pyridazino[1,2-α] [1,2]diazepine-1-carboxylic acid, were successfully separated by the presented procedures. For their chromatographic separation on silica gel sixteen and on PANS thirteen solvents were used.
AB  - U radu je u uslovima hromatografije na tankim slojevima silika-gela i poliakrilonitrilnog sorbenta (PANS-a), izvršeno razdvajanje sledećih antihipertenziva iz grupe angiotenzin konvertujućih enzim inhibitora (ACE inhibitora): Kaptopril-a, Enalapril-a, Lizinopril-a, Kvinapril-a, Ramipril-a, Cilazapril-a. Za njihovo hromatografsko razdvajanje upotrebljeni su mnogi rastvarači. Na osnovu dobijenih rezultata diskutovani su mehanizmi odvajanja. Na taj način data je jedna veoma brza i jednostavna metoda za odvajanje pomenutih supstanci.
PB  - Srpsko hemijsko društvo, Beograd
T2  - Journal of the Serbian Chemical Society
T1  - Thin-layer chromatography of several antihypertensive drugs from the group of angiotensin converting enzyme inhibitors
T1  - Tankoslojna hromatografija nekih antihipertenziva iz grupe angiotenzin konvertujućih enzim inhibitora
VL  - 66
IS  - 1
SP  - 39
EP  - 44
UR  - https://hdl.handle.net/21.15107/rcub_farfar_308
ER  - 
@article{
author = "Aleksić, Mirjana and Agbaba, Danica and Baošić, Rada M. and Milojković-Opsenica, Dušanka and Tešić, Živoslav",
year = "2001",
abstract = "A rapid and simple method for the chromatographic separation of pharmacologically active components contained in some antihypertensive drugs has been developed employing thin-layers of silica gel and polyacrylonitrile sorbent (PANS). The active compounds of Captopril - (S)-1-(3-mercapto-2- methyl-1-oxopropyl)-L-proline, Enalapril - (S)-1-[N-[1-(ethoxycarbonyl)-3- phenylpropyl]-L-alanyl]-L-proline, Lisinopril - (S) -1-[N2-(carboxy-3- phenylpropyl)-L-lysyl]-L-proline, Quinapril - [3S-[2[R*(R*)],3R*]],-2-[2-[[1 (-ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-3- iso-quinoline-carboxylic acid, Ramipril - [2S-[1[R*(R*)],2α,3αβ,6αβ]]-1-[2[[ 1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydrocyclopenta[β]- pyrole-2-carboxylic acid and Cilazapril - [1S-[1α,9α(R*)]]-9-[[1- (ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-6H-pyridazino[1,2-α] [1,2]diazepine-1-carboxylic acid, were successfully separated by the presented procedures. For their chromatographic separation on silica gel sixteen and on PANS thirteen solvents were used., U radu je u uslovima hromatografije na tankim slojevima silika-gela i poliakrilonitrilnog sorbenta (PANS-a), izvršeno razdvajanje sledećih antihipertenziva iz grupe angiotenzin konvertujućih enzim inhibitora (ACE inhibitora): Kaptopril-a, Enalapril-a, Lizinopril-a, Kvinapril-a, Ramipril-a, Cilazapril-a. Za njihovo hromatografsko razdvajanje upotrebljeni su mnogi rastvarači. Na osnovu dobijenih rezultata diskutovani su mehanizmi odvajanja. Na taj način data je jedna veoma brza i jednostavna metoda za odvajanje pomenutih supstanci.",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "Journal of the Serbian Chemical Society",
title = "Thin-layer chromatography of several antihypertensive drugs from the group of angiotensin converting enzyme inhibitors, Tankoslojna hromatografija nekih antihipertenziva iz grupe angiotenzin konvertujućih enzim inhibitora",
volume = "66",
number = "1",
pages = "39-44",
url = "https://hdl.handle.net/21.15107/rcub_farfar_308"
}
Aleksić, M., Agbaba, D., Baošić, R. M., Milojković-Opsenica, D.,& Tešić, Ž.. (2001). Thin-layer chromatography of several antihypertensive drugs from the group of angiotensin converting enzyme inhibitors. in Journal of the Serbian Chemical Society
Srpsko hemijsko društvo, Beograd., 66(1), 39-44.
https://hdl.handle.net/21.15107/rcub_farfar_308
Aleksić M, Agbaba D, Baošić RM, Milojković-Opsenica D, Tešić Ž. Thin-layer chromatography of several antihypertensive drugs from the group of angiotensin converting enzyme inhibitors. in Journal of the Serbian Chemical Society. 2001;66(1):39-44.
https://hdl.handle.net/21.15107/rcub_farfar_308 .
Aleksić, Mirjana, Agbaba, Danica, Baošić, Rada M., Milojković-Opsenica, Dušanka, Tešić, Živoslav, "Thin-layer chromatography of several antihypertensive drugs from the group of angiotensin converting enzyme inhibitors" in Journal of the Serbian Chemical Society, 66, no. 1 (2001):39-44,
https://hdl.handle.net/21.15107/rcub_farfar_308 .

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