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Univerzitet u Beogradu, Farmaceutski fakultet
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Analytical Quality by Design-based development and validation of ultra pressure liquid chromatography/MS/MS method for glycopeptide antibiotics determination in human plasma

Samo za registrovane korisnike
2018
Autori
Stajić, Ana
Maksić, Jelena
Maksić, Đoko
Forsdahl, Guro
Medenica, Mirjana
Jančić-Stojanović, Biljana
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentu
Apstrakt
Aim: An ultra pressure liquid chromatography (UPLC)/MS/MS method for vancomycin and teicoplanin determination in human plasma was developed in accordance with analytical quality by design (AQbD) concept and fully validated. Materials & methods: Chromatographic separation was performed on ACQUITY UPLC C-18 charge surface hybrid (CSH) column (2.1 mm x 50 mm, 1.7 mu m particle size) in gradient mode and the mobile phase consisted of 0.1% formic acid in water and pure acetonitrile. The experimental design methodology was used for the definition of optimal chromatographic and protein precipitation conditions. Results: The linearity ranges were 0.05-10 mu g ml(-1) for vancomycin and 0.5-200 mu g ml(-1) for total teicoplanin. The relative standard deviations for precision estimation were below 15% and the accuracy was within 85-115% for all quality control levels. Conclusion: The method was utilized for glycopeptide antibiotics bioanalysis.
Ključne reči:
AQbD / glycopeptide antibiotics / plasma / UPLC/MS/MS
Izvor:
Bioanalysis, 2018, 10, 22, 1861-1876
Izdavač:
  • Future Sci Ltd, London
Projekti:
  • Modelovanje različitih hromatografskih sistema sa hemometrijskim pristupom u farmaceutskoj analizi (RS-172052)

DOI: 10.4155/bio-2018-0181

ISSN: 1757-6180

PubMed: 30412677

WoS: 000452399800008

Scopus: 2-s2.0-85057740948
[ Google Scholar ]
2
2
URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/3080
Kolekcije
  • Radovi istraživača / Researchers’ publications
Institucija
Pharmacy

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