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dc.creatorStajić, Ana
dc.creatorMaksić, Jelena
dc.creatorMaksić, Đoko
dc.creatorForsdahl, Guro
dc.creatorMedenica, Mirjana
dc.creatorJančić-Stojanović, Biljana
dc.date.accessioned2019-09-02T12:04:16Z
dc.date.available2019-09-02T12:04:16Z
dc.date.issued2018
dc.identifier.issn1757-6180
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/3080
dc.description.abstractAim: An ultra pressure liquid chromatography (UPLC)/MS/MS method for vancomycin and teicoplanin determination in human plasma was developed in accordance with analytical quality by design (AQbD) concept and fully validated. Materials & methods: Chromatographic separation was performed on ACQUITY UPLC C-18 charge surface hybrid (CSH) column (2.1 mm x 50 mm, 1.7 mu m particle size) in gradient mode and the mobile phase consisted of 0.1% formic acid in water and pure acetonitrile. The experimental design methodology was used for the definition of optimal chromatographic and protein precipitation conditions. Results: The linearity ranges were 0.05-10 mu g ml(-1) for vancomycin and 0.5-200 mu g ml(-1) for total teicoplanin. The relative standard deviations for precision estimation were below 15% and the accuracy was within 85-115% for all quality control levels. Conclusion: The method was utilized for glycopeptide antibiotics bioanalysis.en
dc.publisherFuture Sci Ltd, London
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172052/RS//
dc.rightsrestrictedAccess
dc.sourceBioanalysis
dc.subjectAQbDen
dc.subjectglycopeptide antibioticsen
dc.subjectplasmaen
dc.subjectUPLC/MS/MSen
dc.titleAnalytical Quality by Design-based development and validation of ultra pressure liquid chromatography/MS/MS method for glycopeptide antibiotics determination in human plasmaen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМаксић, Ђоко; Јанчић-Стојановић, Биљана; Максић, Јелена; Меденица, Мирјана; Стајић, Aна; Форсдахл, Гуро;
dc.citation.volume10
dc.citation.issue22
dc.citation.spage1861
dc.citation.epage1876
dc.citation.other10(22): 1861-1876
dc.citation.rankM22
dc.identifier.wos000452399800008
dc.identifier.doi10.4155/bio-2018-0181
dc.identifier.pmid30412677
dc.identifier.scopus2-s2.0-85057740948
dc.identifier.rcubconv_4269
dc.type.versionpublishedVersion


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