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Analytical Quality by Design-based development and validation of ultra pressure liquid chromatography/MS/MS method for glycopeptide antibiotics determination in human plasma
dc.creator | Stajić, Ana | |
dc.creator | Maksić, Jelena | |
dc.creator | Maksić, Đoko | |
dc.creator | Forsdahl, Guro | |
dc.creator | Medenica, Mirjana | |
dc.creator | Jančić-Stojanović, Biljana | |
dc.date.accessioned | 2019-09-02T12:04:16Z | |
dc.date.available | 2019-09-02T12:04:16Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 1757-6180 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/3080 | |
dc.description.abstract | Aim: An ultra pressure liquid chromatography (UPLC)/MS/MS method for vancomycin and teicoplanin determination in human plasma was developed in accordance with analytical quality by design (AQbD) concept and fully validated. Materials & methods: Chromatographic separation was performed on ACQUITY UPLC C-18 charge surface hybrid (CSH) column (2.1 mm x 50 mm, 1.7 mu m particle size) in gradient mode and the mobile phase consisted of 0.1% formic acid in water and pure acetonitrile. The experimental design methodology was used for the definition of optimal chromatographic and protein precipitation conditions. Results: The linearity ranges were 0.05-10 mu g ml(-1) for vancomycin and 0.5-200 mu g ml(-1) for total teicoplanin. The relative standard deviations for precision estimation were below 15% and the accuracy was within 85-115% for all quality control levels. Conclusion: The method was utilized for glycopeptide antibiotics bioanalysis. | en |
dc.publisher | Future Sci Ltd, London | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172052/RS// | |
dc.rights | restrictedAccess | |
dc.source | Bioanalysis | |
dc.subject | AQbD | en |
dc.subject | glycopeptide antibiotics | en |
dc.subject | plasma | en |
dc.subject | UPLC/MS/MS | en |
dc.title | Analytical Quality by Design-based development and validation of ultra pressure liquid chromatography/MS/MS method for glycopeptide antibiotics determination in human plasma | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Максић, Ђоко; Јанчић-Стојановић, Биљана; Максић, Јелена; Меденица, Мирјана; Стајић, Aна; Форсдахл, Гуро; | |
dc.citation.volume | 10 | |
dc.citation.issue | 22 | |
dc.citation.spage | 1861 | |
dc.citation.epage | 1876 | |
dc.citation.other | 10(22): 1861-1876 | |
dc.citation.rank | M22 | |
dc.identifier.wos | 000452399800008 | |
dc.identifier.doi | 10.4155/bio-2018-0181 | |
dc.identifier.pmid | 30412677 | |
dc.identifier.scopus | 2-s2.0-85057740948 | |
dc.type.version | publishedVersion |