Association of Dyslipidemia, Oxidative Stress, and Inflammation With Redox Status in VLDL, LDL, and HDL Lipoproteins in Patients With Renal Disease
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2018
Authors
Miljković, Milica
Stefanović, Aleksandra

Simić-Ogrizović, Sanja

Vekić, Jelena

Bogavac-Stanojević, Nataša

Cerne, Darko
Kocbek, Petra
Marc, Janja
Jelić-Ivanović, Zorana

Spasojević-Kalimanovska, Vesna

Kotur-Stevuljević, Jelena

Article (Published version)

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Some cardiovascular complications in patients with chronic kidney disease and end-stage renal disease may be caused by structurally and functionally modified lipoproteins. Redox status (advanced oxidation protein products [AOPPs]), prooxidant-antioxidant balance, total protein sulfhydryl (SH-groups), and paraoxonase 1 (PON1) activity were assessed in 77 renal patients and 20 controls. Lipoproteins were isolated using ultracentrifugation. PON1, PON3, and pentraxin-3 concentration were determined by enzyme-linked immunosorbent assay (ELISA). Dyslipidemia-Oxy-Inflammation (DOI) score was calculated as a sum of dyslipidemia, oxidative stress, and inflammation scores. The dyslipidemia score (P lt .001), oxy score (P lt .01), inflammation score (P lt .001), and the DOI score (P lt .001) were higher in patient groups compared with controls. The very-low-density lipoprotein (VLDL) fraction contained the highest amount of AOPP (P lt .001) compared with other lipoprotein fractions in a...ll groups. The low-density lipoprotein (LDL) fraction contained elevated AOPP in all groups compared with the high-density lipoprotein (HDL) fraction (P lt .001). Significant positive correlation was observed between AOPP in LDL fraction and DOI score (rho = 0.510, P lt .01). Dyslipidemia, oxidative stress, and inflammation play an interactive role in renal disease and are mutually associated with redox status in VLDL, LDL, and HDL lipoproteins in plasma of renal patients.
Keywords:
dyslipidemia / oxidative stress / inflammation / paraoxonase / lipoproteinsSource:
Angiology, 2018, 69, 10, 861-870Publisher:
- Sage Publications Inc, Thousand Oaks
Funding / projects:
DOI: 10.1177/0003319718780041
ISSN: 0003-3197
PubMed: 29909653
WoS: 000446097800004
Scopus: 2-s2.0-85049010440
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PharmacyTY - JOUR AU - Miljković, Milica AU - Stefanović, Aleksandra AU - Simić-Ogrizović, Sanja AU - Vekić, Jelena AU - Bogavac-Stanojević, Nataša AU - Cerne, Darko AU - Kocbek, Petra AU - Marc, Janja AU - Jelić-Ivanović, Zorana AU - Spasojević-Kalimanovska, Vesna AU - Kotur-Stevuljević, Jelena PY - 2018 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3085 AB - Some cardiovascular complications in patients with chronic kidney disease and end-stage renal disease may be caused by structurally and functionally modified lipoproteins. Redox status (advanced oxidation protein products [AOPPs]), prooxidant-antioxidant balance, total protein sulfhydryl (SH-groups), and paraoxonase 1 (PON1) activity were assessed in 77 renal patients and 20 controls. Lipoproteins were isolated using ultracentrifugation. PON1, PON3, and pentraxin-3 concentration were determined by enzyme-linked immunosorbent assay (ELISA). Dyslipidemia-Oxy-Inflammation (DOI) score was calculated as a sum of dyslipidemia, oxidative stress, and inflammation scores. The dyslipidemia score (P lt .001), oxy score (P lt .01), inflammation score (P lt .001), and the DOI score (P lt .001) were higher in patient groups compared with controls. The very-low-density lipoprotein (VLDL) fraction contained the highest amount of AOPP (P lt .001) compared with other lipoprotein fractions in all groups. The low-density lipoprotein (LDL) fraction contained elevated AOPP in all groups compared with the high-density lipoprotein (HDL) fraction (P lt .001). Significant positive correlation was observed between AOPP in LDL fraction and DOI score (rho = 0.510, P lt .01). Dyslipidemia, oxidative stress, and inflammation play an interactive role in renal disease and are mutually associated with redox status in VLDL, LDL, and HDL lipoproteins in plasma of renal patients. PB - Sage Publications Inc, Thousand Oaks T2 - Angiology T1 - Association of Dyslipidemia, Oxidative Stress, and Inflammation With Redox Status in VLDL, LDL, and HDL Lipoproteins in Patients With Renal Disease VL - 69 IS - 10 SP - 861 EP - 870 DO - 10.1177/0003319718780041 ER -
@article{ author = "Miljković, Milica and Stefanović, Aleksandra and Simić-Ogrizović, Sanja and Vekić, Jelena and Bogavac-Stanojević, Nataša and Cerne, Darko and Kocbek, Petra and Marc, Janja and Jelić-Ivanović, Zorana and Spasojević-Kalimanovska, Vesna and Kotur-Stevuljević, Jelena", year = "2018", abstract = "Some cardiovascular complications in patients with chronic kidney disease and end-stage renal disease may be caused by structurally and functionally modified lipoproteins. Redox status (advanced oxidation protein products [AOPPs]), prooxidant-antioxidant balance, total protein sulfhydryl (SH-groups), and paraoxonase 1 (PON1) activity were assessed in 77 renal patients and 20 controls. Lipoproteins were isolated using ultracentrifugation. PON1, PON3, and pentraxin-3 concentration were determined by enzyme-linked immunosorbent assay (ELISA). Dyslipidemia-Oxy-Inflammation (DOI) score was calculated as a sum of dyslipidemia, oxidative stress, and inflammation scores. The dyslipidemia score (P lt .001), oxy score (P lt .01), inflammation score (P lt .001), and the DOI score (P lt .001) were higher in patient groups compared with controls. The very-low-density lipoprotein (VLDL) fraction contained the highest amount of AOPP (P lt .001) compared with other lipoprotein fractions in all groups. The low-density lipoprotein (LDL) fraction contained elevated AOPP in all groups compared with the high-density lipoprotein (HDL) fraction (P lt .001). Significant positive correlation was observed between AOPP in LDL fraction and DOI score (rho = 0.510, P lt .01). Dyslipidemia, oxidative stress, and inflammation play an interactive role in renal disease and are mutually associated with redox status in VLDL, LDL, and HDL lipoproteins in plasma of renal patients.", publisher = "Sage Publications Inc, Thousand Oaks", journal = "Angiology", title = "Association of Dyslipidemia, Oxidative Stress, and Inflammation With Redox Status in VLDL, LDL, and HDL Lipoproteins in Patients With Renal Disease", volume = "69", number = "10", pages = "861-870", doi = "10.1177/0003319718780041" }
Miljković, M., Stefanović, A., Simić-Ogrizović, S., Vekić, J., Bogavac-Stanojević, N., Cerne, D., Kocbek, P., Marc, J., Jelić-Ivanović, Z., Spasojević-Kalimanovska, V.,& Kotur-Stevuljević, J.. (2018). Association of Dyslipidemia, Oxidative Stress, and Inflammation With Redox Status in VLDL, LDL, and HDL Lipoproteins in Patients With Renal Disease. in Angiology Sage Publications Inc, Thousand Oaks., 69(10), 861-870. https://doi.org/10.1177/0003319718780041
Miljković M, Stefanović A, Simić-Ogrizović S, Vekić J, Bogavac-Stanojević N, Cerne D, Kocbek P, Marc J, Jelić-Ivanović Z, Spasojević-Kalimanovska V, Kotur-Stevuljević J. Association of Dyslipidemia, Oxidative Stress, and Inflammation With Redox Status in VLDL, LDL, and HDL Lipoproteins in Patients With Renal Disease. in Angiology. 2018;69(10):861-870. doi:10.1177/0003319718780041 .
Miljković, Milica, Stefanović, Aleksandra, Simić-Ogrizović, Sanja, Vekić, Jelena, Bogavac-Stanojević, Nataša, Cerne, Darko, Kocbek, Petra, Marc, Janja, Jelić-Ivanović, Zorana, Spasojević-Kalimanovska, Vesna, Kotur-Stevuljević, Jelena, "Association of Dyslipidemia, Oxidative Stress, and Inflammation With Redox Status in VLDL, LDL, and HDL Lipoproteins in Patients With Renal Disease" in Angiology, 69, no. 10 (2018):861-870, https://doi.org/10.1177/0003319718780041 . .