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dc.creatorMiljković, Milica
dc.creatorStefanović, Aleksandra
dc.creatorSimić-Ogrizović, Sanja
dc.creatorVekić, Jelena
dc.creatorBogavac-Stanojević, Nataša
dc.creatorCerne, Darko
dc.creatorKocbek, Petra
dc.creatorMarc, Janja
dc.creatorJelić-Ivanović, Zorana
dc.creatorSpasojević-Kalimanovska, Vesna
dc.creatorKotur-Stevuljević, Jelena
dc.date.accessioned2019-09-02T12:04:24Z
dc.date.available2019-09-02T12:04:24Z
dc.date.issued2018
dc.identifier.issn0003-3197
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/3085
dc.description.abstractSome cardiovascular complications in patients with chronic kidney disease and end-stage renal disease may be caused by structurally and functionally modified lipoproteins. Redox status (advanced oxidation protein products [AOPPs]), prooxidant-antioxidant balance, total protein sulfhydryl (SH-groups), and paraoxonase 1 (PON1) activity were assessed in 77 renal patients and 20 controls. Lipoproteins were isolated using ultracentrifugation. PON1, PON3, and pentraxin-3 concentration were determined by enzyme-linked immunosorbent assay (ELISA). Dyslipidemia-Oxy-Inflammation (DOI) score was calculated as a sum of dyslipidemia, oxidative stress, and inflammation scores. The dyslipidemia score (P lt .001), oxy score (P lt .01), inflammation score (P lt .001), and the DOI score (P lt .001) were higher in patient groups compared with controls. The very-low-density lipoprotein (VLDL) fraction contained the highest amount of AOPP (P lt .001) compared with other lipoprotein fractions in all groups. The low-density lipoprotein (LDL) fraction contained elevated AOPP in all groups compared with the high-density lipoprotein (HDL) fraction (P lt .001). Significant positive correlation was observed between AOPP in LDL fraction and DOI score (rho = 0.510, P lt .01). Dyslipidemia, oxidative stress, and inflammation play an interactive role in renal disease and are mutually associated with redox status in VLDL, LDL, and HDL lipoproteins in plasma of renal patients.en
dc.publisherSage Publications Inc, Thousand Oaks
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175035/RS//
dc.rightsrestrictedAccess
dc.sourceAngiology
dc.subjectdyslipidemiaen
dc.subjectoxidative stressen
dc.subjectinflammationen
dc.subjectparaoxonaseen
dc.subjectlipoproteinsen
dc.titleAssociation of Dyslipidemia, Oxidative Stress, and Inflammation With Redox Status in VLDL, LDL, and HDL Lipoproteins in Patients With Renal Diseaseen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractКотур-Стевуљевић, Јелена; Коцбек, Петра; Стефановић, Aлександра; Симић-Огризовић, Сања; Церне, Дарко; Спасојевић-Калимановска, Весна; Богавац-Станојевић, Наташа; Јелић-Ивановић, Зорана; Марц, Јања; Векић, Јелена; Миљковић, Милица;
dc.citation.volume69
dc.citation.issue10
dc.citation.spage861
dc.citation.epage870
dc.citation.other69(10): 861-870
dc.citation.rankM22
dc.identifier.wos000446097800004
dc.identifier.doi10.1177/0003319718780041
dc.identifier.pmid29909653
dc.identifier.scopus2-s2.0-85049010440
dc.type.versionpublishedVersion


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