Thin-layer chromatography of several antihypertensive drugs from the group of angiotensin converting enzyme inhibitors
Tankoslojna hromatografija nekih antihipertenziva iz grupe angiotenzin konvertujućih enzim inhibitora
Apstrakt
A rapid and simple method for the chromatographic separation of pharmacologically active components contained in some antihypertensive drugs has been developed employing thin-layers of silica gel and polyacrylonitrile sorbent (PANS). The active compounds of Captopril - (S)-1-(3-mercapto-2- methyl-1-oxopropyl)-L-proline, Enalapril - (S)-1-[N-[1-(ethoxycarbonyl)-3- phenylpropyl]-L-alanyl]-L-proline, Lisinopril - (S) -1-[N2-(carboxy-3- phenylpropyl)-L-lysyl]-L-proline, Quinapril - [3S-[2[R*(R*)],3R*]],-2-[2-[[1 (-ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-3- iso-quinoline-carboxylic acid, Ramipril - [2S-[1[R*(R*)],2α,3αβ,6αβ]]-1-[2[[ 1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydrocyclopenta[β]- pyrole-2-carboxylic acid and Cilazapril - [1S-[1α,9α(R*)]]-9-[[1- (ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-6H-pyridazino[1,2-α] [1,2]diazepine-1-carboxylic acid, were successfully separated by the presented procedures. For their chromatographi...c separation on silica gel sixteen and on PANS thirteen solvents were used.
U radu je u uslovima hromatografije na tankim slojevima silika-gela i poliakrilonitrilnog sorbenta (PANS-a), izvršeno razdvajanje sledećih antihipertenziva iz grupe angiotenzin konvertujućih enzim inhibitora (ACE inhibitora): Kaptopril-a, Enalapril-a, Lizinopril-a, Kvinapril-a, Ramipril-a, Cilazapril-a. Za njihovo hromatografsko razdvajanje upotrebljeni su mnogi rastvarači. Na osnovu dobijenih rezultata diskutovani su mehanizmi odvajanja. Na taj način data je jedna veoma brza i jednostavna metoda za odvajanje pomenutih supstanci.
Ključne reči:
thin-layer chromatography / silica gel / polyacrylonitrile sorbent / antihypertensive drugs / angiotensin converting enzyme inhibitorsIzvor:
Journal of the Serbian Chemical Society, 2001, 66, 1, 39-44Izdavač:
- Srpsko hemijsko društvo, Beograd
Institucija/grupa
PharmacyTY - JOUR AU - Aleksić, Mirjana AU - Agbaba, Danica AU - Baošić, Rada M. AU - Milojković-Opsenica, Dušanka AU - Tešić, Živoslav PY - 2001 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/308 AB - A rapid and simple method for the chromatographic separation of pharmacologically active components contained in some antihypertensive drugs has been developed employing thin-layers of silica gel and polyacrylonitrile sorbent (PANS). The active compounds of Captopril - (S)-1-(3-mercapto-2- methyl-1-oxopropyl)-L-proline, Enalapril - (S)-1-[N-[1-(ethoxycarbonyl)-3- phenylpropyl]-L-alanyl]-L-proline, Lisinopril - (S) -1-[N2-(carboxy-3- phenylpropyl)-L-lysyl]-L-proline, Quinapril - [3S-[2[R*(R*)],3R*]],-2-[2-[[1 (-ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-3- iso-quinoline-carboxylic acid, Ramipril - [2S-[1[R*(R*)],2α,3αβ,6αβ]]-1-[2[[ 1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydrocyclopenta[β]- pyrole-2-carboxylic acid and Cilazapril - [1S-[1α,9α(R*)]]-9-[[1- (ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-6H-pyridazino[1,2-α] [1,2]diazepine-1-carboxylic acid, were successfully separated by the presented procedures. For their chromatographic separation on silica gel sixteen and on PANS thirteen solvents were used. AB - U radu je u uslovima hromatografije na tankim slojevima silika-gela i poliakrilonitrilnog sorbenta (PANS-a), izvršeno razdvajanje sledećih antihipertenziva iz grupe angiotenzin konvertujućih enzim inhibitora (ACE inhibitora): Kaptopril-a, Enalapril-a, Lizinopril-a, Kvinapril-a, Ramipril-a, Cilazapril-a. Za njihovo hromatografsko razdvajanje upotrebljeni su mnogi rastvarači. Na osnovu dobijenih rezultata diskutovani su mehanizmi odvajanja. Na taj način data je jedna veoma brza i jednostavna metoda za odvajanje pomenutih supstanci. PB - Srpsko hemijsko društvo, Beograd T2 - Journal of the Serbian Chemical Society T1 - Thin-layer chromatography of several antihypertensive drugs from the group of angiotensin converting enzyme inhibitors T1 - Tankoslojna hromatografija nekih antihipertenziva iz grupe angiotenzin konvertujućih enzim inhibitora VL - 66 IS - 1 SP - 39 EP - 44 UR - https://hdl.handle.net/21.15107/rcub_farfar_308 ER -
@article{ author = "Aleksić, Mirjana and Agbaba, Danica and Baošić, Rada M. and Milojković-Opsenica, Dušanka and Tešić, Živoslav", year = "2001", abstract = "A rapid and simple method for the chromatographic separation of pharmacologically active components contained in some antihypertensive drugs has been developed employing thin-layers of silica gel and polyacrylonitrile sorbent (PANS). The active compounds of Captopril - (S)-1-(3-mercapto-2- methyl-1-oxopropyl)-L-proline, Enalapril - (S)-1-[N-[1-(ethoxycarbonyl)-3- phenylpropyl]-L-alanyl]-L-proline, Lisinopril - (S) -1-[N2-(carboxy-3- phenylpropyl)-L-lysyl]-L-proline, Quinapril - [3S-[2[R*(R*)],3R*]],-2-[2-[[1 (-ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-3- iso-quinoline-carboxylic acid, Ramipril - [2S-[1[R*(R*)],2α,3αβ,6αβ]]-1-[2[[ 1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydrocyclopenta[β]- pyrole-2-carboxylic acid and Cilazapril - [1S-[1α,9α(R*)]]-9-[[1- (ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-6H-pyridazino[1,2-α] [1,2]diazepine-1-carboxylic acid, were successfully separated by the presented procedures. For their chromatographic separation on silica gel sixteen and on PANS thirteen solvents were used., U radu je u uslovima hromatografije na tankim slojevima silika-gela i poliakrilonitrilnog sorbenta (PANS-a), izvršeno razdvajanje sledećih antihipertenziva iz grupe angiotenzin konvertujućih enzim inhibitora (ACE inhibitora): Kaptopril-a, Enalapril-a, Lizinopril-a, Kvinapril-a, Ramipril-a, Cilazapril-a. Za njihovo hromatografsko razdvajanje upotrebljeni su mnogi rastvarači. Na osnovu dobijenih rezultata diskutovani su mehanizmi odvajanja. Na taj način data je jedna veoma brza i jednostavna metoda za odvajanje pomenutih supstanci.", publisher = "Srpsko hemijsko društvo, Beograd", journal = "Journal of the Serbian Chemical Society", title = "Thin-layer chromatography of several antihypertensive drugs from the group of angiotensin converting enzyme inhibitors, Tankoslojna hromatografija nekih antihipertenziva iz grupe angiotenzin konvertujućih enzim inhibitora", volume = "66", number = "1", pages = "39-44", url = "https://hdl.handle.net/21.15107/rcub_farfar_308" }
Aleksić, M., Agbaba, D., Baošić, R. M., Milojković-Opsenica, D.,& Tešić, Ž.. (2001). Thin-layer chromatography of several antihypertensive drugs from the group of angiotensin converting enzyme inhibitors. in Journal of the Serbian Chemical Society Srpsko hemijsko društvo, Beograd., 66(1), 39-44. https://hdl.handle.net/21.15107/rcub_farfar_308
Aleksić M, Agbaba D, Baošić RM, Milojković-Opsenica D, Tešić Ž. Thin-layer chromatography of several antihypertensive drugs from the group of angiotensin converting enzyme inhibitors. in Journal of the Serbian Chemical Society. 2001;66(1):39-44. https://hdl.handle.net/21.15107/rcub_farfar_308 .
Aleksić, Mirjana, Agbaba, Danica, Baošić, Rada M., Milojković-Opsenica, Dušanka, Tešić, Živoslav, "Thin-layer chromatography of several antihypertensive drugs from the group of angiotensin converting enzyme inhibitors" in Journal of the Serbian Chemical Society, 66, no. 1 (2001):39-44, https://hdl.handle.net/21.15107/rcub_farfar_308 .