Приказ основних података о документу
Thin-layer chromatography of several antihypertensive drugs from the group of angiotensin converting enzyme inhibitors
Tankoslojna hromatografija nekih antihipertenziva iz grupe angiotenzin konvertujućih enzim inhibitora
dc.creator | Aleksić, Mirjana | |
dc.creator | Agbaba, Danica | |
dc.creator | Baošić, Rada M. | |
dc.creator | Milojković-Opsenica, Dušanka | |
dc.creator | Tešić, Živoslav | |
dc.date.accessioned | 2019-09-02T10:53:47Z | |
dc.date.available | 2019-09-02T10:53:47Z | |
dc.date.issued | 2001 | |
dc.identifier.issn | 0352-5139 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/308 | |
dc.description.abstract | A rapid and simple method for the chromatographic separation of pharmacologically active components contained in some antihypertensive drugs has been developed employing thin-layers of silica gel and polyacrylonitrile sorbent (PANS). The active compounds of Captopril - (S)-1-(3-mercapto-2- methyl-1-oxopropyl)-L-proline, Enalapril - (S)-1-[N-[1-(ethoxycarbonyl)-3- phenylpropyl]-L-alanyl]-L-proline, Lisinopril - (S) -1-[N2-(carboxy-3- phenylpropyl)-L-lysyl]-L-proline, Quinapril - [3S-[2[R*(R*)],3R*]],-2-[2-[[1 (-ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-3- iso-quinoline-carboxylic acid, Ramipril - [2S-[1[R*(R*)],2α,3αβ,6αβ]]-1-[2[[ 1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydrocyclopenta[β]- pyrole-2-carboxylic acid and Cilazapril - [1S-[1α,9α(R*)]]-9-[[1- (ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-6H-pyridazino[1,2-α] [1,2]diazepine-1-carboxylic acid, were successfully separated by the presented procedures. For their chromatographic separation on silica gel sixteen and on PANS thirteen solvents were used. | en |
dc.description.abstract | U radu je u uslovima hromatografije na tankim slojevima silika-gela i poliakrilonitrilnog sorbenta (PANS-a), izvršeno razdvajanje sledećih antihipertenziva iz grupe angiotenzin konvertujućih enzim inhibitora (ACE inhibitora): Kaptopril-a, Enalapril-a, Lizinopril-a, Kvinapril-a, Ramipril-a, Cilazapril-a. Za njihovo hromatografsko razdvajanje upotrebljeni su mnogi rastvarači. Na osnovu dobijenih rezultata diskutovani su mehanizmi odvajanja. Na taj način data je jedna veoma brza i jednostavna metoda za odvajanje pomenutih supstanci. | sr |
dc.publisher | Srpsko hemijsko društvo, Beograd | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | Journal of the Serbian Chemical Society | |
dc.subject | thin-layer chromatography | en |
dc.subject | silica gel | en |
dc.subject | polyacrylonitrile sorbent | en |
dc.subject | antihypertensive drugs | en |
dc.subject | angiotensin converting enzyme inhibitors | en |
dc.title | Thin-layer chromatography of several antihypertensive drugs from the group of angiotensin converting enzyme inhibitors | en |
dc.title | Tankoslojna hromatografija nekih antihipertenziva iz grupe angiotenzin konvertujućih enzim inhibitora | sr |
dc.type | article | |
dc.rights.license | BY-NC-ND | |
dcterms.abstract | Aгбаба, Даница; Милојковић-Опсеница, Душанка; Тешић, Живослав; Aлексић, Мирјана; Баошић, Рада М.; Танкослојна хроматографија неких антихипертензива из групе ангиотензин конвертујућих ензим инхибитора; Танкослојна хроматографија неких антихипертензива из групе ангиотензин конвертујућих ензим инхибитора; | |
dc.citation.volume | 66 | |
dc.citation.issue | 1 | |
dc.citation.spage | 39 | |
dc.citation.epage | 44 | |
dc.citation.other | 66(1): 39-44 | |
dc.citation.rank | M23 | |
dc.identifier.wos | 000166757200006 | |
dc.identifier.scopus | 2-s2.0-5844370750 | |
dc.identifier.fulltext | https://farfar.pharmacy.bg.ac.rs//bitstream/id/1674/306.pdf | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_farfar_308 | |
dc.type.version | publishedVersion |