Oral treatment with Lactobacillus rhamnosus 64 during the early postnatal period improves the health of adult rats with TNBS-induced colitis
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2018
Authors
Stanojević, StanislavaBlagojević, Veljko

Curuvija, Ivana
Veljović, Katarina
Soković-Bajić, Svetlana
Kotur-Stevuljević, Jelena

Bogdanović, Andrija

Petrović, Raisa
Vujnović, Ivana
Kovačević-Jovanović, Vesna
Article (Published version)

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The current study investigated a potential modulating effect of orally applied Lactobacillus rhamnosus 64 (LB64) during the early postnatal period (day of life: similar to 3-30), during young adult period (day of life: 31-70) or throughout experiment, on parameters of trinitrobenzenesulfonic acid (TNBS)-induced colitis in adult rats. Treatment with LB64 during early postnatal, but not during young adult period reduced clinical damage score, neutrophil and macrophage infiltration into colon, the level of cytokine and myeloperoxidase (MPO) activity, but had no influence on other parameters of oxidative damage. Early postnatal treatment with LB64 also increased the diversity of fecal Bifidobacteria and Eubacteria, and improved maturation of ileal villi in 30-days old rats. When LB64 is applied during a critical period early in life, it affects immune system functioning of adults, probably by interactions with the mucosal immune system of the gastrointestinal tract that provides immune sys...tem maturation and shapes the overall immune response.
Keywords:
Lactobacillus rhamnosus 64 / Early postnatal treatment / Microbiota diversity / Rats / TNBS-induced colitisSource:
Journal of Functional Foods, 2018, 48, 92-105Publisher:
- Elsevier Science BV, Amsterdam
Funding / projects:
DOI: 10.1016/j.jff.2018.07.014
ISSN: 1756-4646
WoS: 000447573600010
Scopus: 2-s2.0-85049437192
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PharmacyTY - JOUR AU - Stanojević, Stanislava AU - Blagojević, Veljko AU - Curuvija, Ivana AU - Veljović, Katarina AU - Soković-Bajić, Svetlana AU - Kotur-Stevuljević, Jelena AU - Bogdanović, Andrija AU - Petrović, Raisa AU - Vujnović, Ivana AU - Kovačević-Jovanović, Vesna PY - 2018 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3091 AB - The current study investigated a potential modulating effect of orally applied Lactobacillus rhamnosus 64 (LB64) during the early postnatal period (day of life: similar to 3-30), during young adult period (day of life: 31-70) or throughout experiment, on parameters of trinitrobenzenesulfonic acid (TNBS)-induced colitis in adult rats. Treatment with LB64 during early postnatal, but not during young adult period reduced clinical damage score, neutrophil and macrophage infiltration into colon, the level of cytokine and myeloperoxidase (MPO) activity, but had no influence on other parameters of oxidative damage. Early postnatal treatment with LB64 also increased the diversity of fecal Bifidobacteria and Eubacteria, and improved maturation of ileal villi in 30-days old rats. When LB64 is applied during a critical period early in life, it affects immune system functioning of adults, probably by interactions with the mucosal immune system of the gastrointestinal tract that provides immune system maturation and shapes the overall immune response. PB - Elsevier Science BV, Amsterdam T2 - Journal of Functional Foods T1 - Oral treatment with Lactobacillus rhamnosus 64 during the early postnatal period improves the health of adult rats with TNBS-induced colitis VL - 48 SP - 92 EP - 105 DO - 10.1016/j.jff.2018.07.014 ER -
@article{ author = "Stanojević, Stanislava and Blagojević, Veljko and Curuvija, Ivana and Veljović, Katarina and Soković-Bajić, Svetlana and Kotur-Stevuljević, Jelena and Bogdanović, Andrija and Petrović, Raisa and Vujnović, Ivana and Kovačević-Jovanović, Vesna", year = "2018", abstract = "The current study investigated a potential modulating effect of orally applied Lactobacillus rhamnosus 64 (LB64) during the early postnatal period (day of life: similar to 3-30), during young adult period (day of life: 31-70) or throughout experiment, on parameters of trinitrobenzenesulfonic acid (TNBS)-induced colitis in adult rats. Treatment with LB64 during early postnatal, but not during young adult period reduced clinical damage score, neutrophil and macrophage infiltration into colon, the level of cytokine and myeloperoxidase (MPO) activity, but had no influence on other parameters of oxidative damage. Early postnatal treatment with LB64 also increased the diversity of fecal Bifidobacteria and Eubacteria, and improved maturation of ileal villi in 30-days old rats. When LB64 is applied during a critical period early in life, it affects immune system functioning of adults, probably by interactions with the mucosal immune system of the gastrointestinal tract that provides immune system maturation and shapes the overall immune response.", publisher = "Elsevier Science BV, Amsterdam", journal = "Journal of Functional Foods", title = "Oral treatment with Lactobacillus rhamnosus 64 during the early postnatal period improves the health of adult rats with TNBS-induced colitis", volume = "48", pages = "92-105", doi = "10.1016/j.jff.2018.07.014" }
Stanojević, S., Blagojević, V., Curuvija, I., Veljović, K., Soković-Bajić, S., Kotur-Stevuljević, J., Bogdanović, A., Petrović, R., Vujnović, I.,& Kovačević-Jovanović, V.. (2018). Oral treatment with Lactobacillus rhamnosus 64 during the early postnatal period improves the health of adult rats with TNBS-induced colitis. in Journal of Functional Foods Elsevier Science BV, Amsterdam., 48, 92-105. https://doi.org/10.1016/j.jff.2018.07.014
Stanojević S, Blagojević V, Curuvija I, Veljović K, Soković-Bajić S, Kotur-Stevuljević J, Bogdanović A, Petrović R, Vujnović I, Kovačević-Jovanović V. Oral treatment with Lactobacillus rhamnosus 64 during the early postnatal period improves the health of adult rats with TNBS-induced colitis. in Journal of Functional Foods. 2018;48:92-105. doi:10.1016/j.jff.2018.07.014 .
Stanojević, Stanislava, Blagojević, Veljko, Curuvija, Ivana, Veljović, Katarina, Soković-Bajić, Svetlana, Kotur-Stevuljević, Jelena, Bogdanović, Andrija, Petrović, Raisa, Vujnović, Ivana, Kovačević-Jovanović, Vesna, "Oral treatment with Lactobacillus rhamnosus 64 during the early postnatal period improves the health of adult rats with TNBS-induced colitis" in Journal of Functional Foods, 48 (2018):92-105, https://doi.org/10.1016/j.jff.2018.07.014 . .