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Manuka honey attenuates oxidative damage induced by H2O2 in human whole blood in vitro
dc.creator | Živković, Lada | |
dc.creator | Bajić, Vladan | |
dc.creator | Dekanski, Dragana | |
dc.creator | Pirković, Andrea | |
dc.creator | Giampieri, Francesca | |
dc.creator | Gasparrini, Massimiliano | |
dc.creator | Mazzoni, Luca | |
dc.creator | Potparević, Biljana | |
dc.date.accessioned | 2019-09-02T12:04:33Z | |
dc.date.available | 2019-09-02T12:04:33Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 0278-6915 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/3092 | |
dc.description.abstract | Manuka honey has been widely researched regarding its biological properties, in particular its antimicrobial and antioxidant capacities. We tested the genotoxic and genoprotective properties of Manuka honey, ranging from 25-1000 mu g/mL, by performing an in vitro comet assay after exposure to human whole blood. No genotoxic effect on whole blood cells was observed within the tested concentration range (p = 0.154). Then, the antigenotoxic potency of Manuka honey against oxidative DNA damage to whole blood cells was assessed. Prior to Manuka honey treatment a modest decrease of H2O2-induced DNA damage was detected in cells, with no statistical significance (p = 0.087). Post-treatment, Manuka honey displayed a stronger potential to attenuate damaged cells at all tested concentrations, with a statistical significant difference (p lt 0.001), where concentrations of 25 and 100 mu g/mL were most efficient. Manuka honey exhibited a marked potential to protect DNA of whole blood cells from oxidative damage induced by hydrogen peroxide in vitro. | en |
dc.publisher | Pergamon-Elsevier Science Ltd, Oxford | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173034/RS// | |
dc.rights | restrictedAccess | |
dc.source | Food and Chemical Toxicology | |
dc.title | Manuka honey attenuates oxidative damage induced by H2O2 in human whole blood in vitro | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Живковић, Лада; Маззони, Луца; Декански, Драгана; Пирковић, Aндреа; Бајић, Владан; Потпаревић, Биљана; Гаспаррини, Массимилиано; Гиампиери, Францесца; | |
dc.citation.volume | 119 | |
dc.citation.spage | 61 | |
dc.citation.epage | 65 | |
dc.citation.other | 119: 61-65 | |
dc.citation.rank | M21 | |
dc.identifier.wos | 000443664200009 | |
dc.identifier.doi | 10.1016/j.fct.2018.05.034 | |
dc.identifier.pmid | 29763681 | |
dc.identifier.scopus | 2-s2.0-85048158869 | |
dc.type.version | publishedVersion |