Приказ основних података о документу

dc.creatorŽivković, Lada
dc.creatorBajić, Vladan
dc.creatorDekanski, Dragana
dc.creatorPirković, Andrea
dc.creatorGiampieri, Francesca
dc.creatorGasparrini, Massimiliano
dc.creatorMazzoni, Luca
dc.creatorPotparević, Biljana
dc.date.accessioned2019-09-02T12:04:33Z
dc.date.available2019-09-02T12:04:33Z
dc.date.issued2018
dc.identifier.issn0278-6915
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/3092
dc.description.abstractManuka honey has been widely researched regarding its biological properties, in particular its antimicrobial and antioxidant capacities. We tested the genotoxic and genoprotective properties of Manuka honey, ranging from 25-1000 mu g/mL, by performing an in vitro comet assay after exposure to human whole blood. No genotoxic effect on whole blood cells was observed within the tested concentration range (p = 0.154). Then, the antigenotoxic potency of Manuka honey against oxidative DNA damage to whole blood cells was assessed. Prior to Manuka honey treatment a modest decrease of H2O2-induced DNA damage was detected in cells, with no statistical significance (p = 0.087). Post-treatment, Manuka honey displayed a stronger potential to attenuate damaged cells at all tested concentrations, with a statistical significant difference (p lt 0.001), where concentrations of 25 and 100 mu g/mL were most efficient. Manuka honey exhibited a marked potential to protect DNA of whole blood cells from oxidative damage induced by hydrogen peroxide in vitro.en
dc.publisherPergamon-Elsevier Science Ltd, Oxford
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173034/RS//
dc.rightsrestrictedAccess
dc.sourceFood and Chemical Toxicology
dc.titleManuka honey attenuates oxidative damage induced by H2O2 in human whole blood in vitroen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЖивковић, Лада; Маззони, Луца; Декански, Драгана; Пирковић, Aндреа; Бајић, Владан; Потпаревић, Биљана; Гаспаррини, Массимилиано; Гиампиери, Францесца;
dc.citation.volume119
dc.citation.spage61
dc.citation.epage65
dc.citation.other119: 61-65
dc.citation.rankM21
dc.identifier.wos000443664200009
dc.identifier.doi10.1016/j.fct.2018.05.034
dc.identifier.pmid29763681
dc.identifier.scopus2-s2.0-85048158869
dc.type.versionpublishedVersion


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Приказ основних података о документу