Effect of Circulation Chamber Dimensions on Aerosol Delivery Efficiency of a Commertial Dry Powder Inhaler Aerolizer (R)
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Aim of this study was to analyze how modifications in circulation chamber dimensions affect aerosol particle deposition in a Dry Powder Inhaler (DPI) Aerolizer. Combining computational fluid dynamics (CFD), for simulation of fluid flow (air), with discrete phase model (DPM) for particles simulation, we can better understand particle dispersion within inhaler's air flow field. Input in the simulation was 20mg of aerosol particles with initial velocity of 11,79166m/s. Dimension change influences maximum velocities, as well as percentage of deposited particles. Based on these information we were able to calculate the number of particles on the outlet and compare efficiency reduction when circulation chamber height increased. Knowledge obtained in this way can help in device performance optimization.
Keywords:aerosol particle deposition / dimension change / dry powder inhaler AerolizerÂ® / performance optimization
Source:Proceedings - 2017 IEEE 17th International Conference on Bioinformatics and Bioengineering, BIBE 201, 2018, 555-558
- Institute of Electrical and Electronics Engineers Inc.
- EU COST Action MP1404