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Gentamicin-Loaded Bioactive Hydroxyapatite/Chitosan Composite Coating Electrodeposited on Titanium

Authorized Users Only
2018
Authors
Stevanović, Milena
Đosić, Marija
Janković, Ana
Kojić, Vesna
Vukašinović-Sekulić, Maja
Stojanović, Jovica
Odović, Jadranka
Crevar-Sakač, Milkica
Rhee, Kyong Yop
Mišković-Stanković, Vesna
Article (Published version)
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Abstract
Composite coating of antibiotic gentamicin (Gent), natural polymer chitosan (CS), and hydroxyapatite (HAP) was successfully assessed by applying the electrophoretic deposition (EPD) technique. EPD was performed under optimized deposition conditions (5 V, 12 min) on pure titanium plates, to obtain HAP/CS and HAP/CS/Gent composite coatings in a single step from three-component aqueous suspension, with favorable antibacterial properties. Composite coatings were characterized by X-ray diffraction (XRD), field emission scanning electron microscopy, Fourier transform infrared spectroscopy, thermogravimetric analysis, and X-ray photoelectron analysis, confirming the formation of composite HAP/CS and HAP/CS/Gent coatings on the titanium surface, which is due to intermolecular hydrogen bonds. Employing the XRD technique, HAP was detected by obtaining the characteristic diffraction maximums. Good antibacterial activity of the composite coating loaded with antibiotic (HAP/CS/Gent) was confirmed a...gainst Staphylococcus aureus and Escherichia coli, pointing to the high potential for bioapplication. Introduction of gentamicin in HAP/CS/Gent coating caused very mild cytotoxicity in the tested cell lines MRC-5 and L929. MTT testing was used to evaluate cell viability, and HAP/CS was classified as noncytotoxic.

Keywords:
biocomposite / coatings / electrophoretic deposition / surface analysis / antibacterial activity
Source:
ACS Biomaterials Science & Engineering, 2018, 4, 12, 3994-4007
Publisher:
  • Amer Chemical Soc, Washington
Projects:
  • Basic Science Research Program of the Ministry of Education, Science and Technology of Korea - 2018R1A2B5A02023190

DOI: 10.1021/acsbiomaterials.8b00859

ISSN: 2373-9878

WoS: 000453109000008

Scopus: 2-s2.0-85058300298
[ Google Scholar ]
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18
URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/3123
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  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy

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