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dc.creatorStevanović, Milena
dc.creatorĐosić, Marija
dc.creatorJanković, Ana
dc.creatorKojić, Vesna
dc.creatorVukašinović-Sekulić, Maja
dc.creatorStojanović, Jovica
dc.creatorOdović, Jadranka
dc.creatorCrevar-Sakač, Milkica
dc.creatorRhee, Kyong Yop
dc.creatorMišković-Stanković, Vesna
dc.date.accessioned2019-09-02T12:05:23Z
dc.date.available2019-09-02T12:05:23Z
dc.date.issued2018
dc.identifier.issn2373-9878
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/3123
dc.description.abstractComposite coating of antibiotic gentamicin (Gent), natural polymer chitosan (CS), and hydroxyapatite (HAP) was successfully assessed by applying the electrophoretic deposition (EPD) technique. EPD was performed under optimized deposition conditions (5 V, 12 min) on pure titanium plates, to obtain HAP/CS and HAP/CS/Gent composite coatings in a single step from three-component aqueous suspension, with favorable antibacterial properties. Composite coatings were characterized by X-ray diffraction (XRD), field emission scanning electron microscopy, Fourier transform infrared spectroscopy, thermogravimetric analysis, and X-ray photoelectron analysis, confirming the formation of composite HAP/CS and HAP/CS/Gent coatings on the titanium surface, which is due to intermolecular hydrogen bonds. Employing the XRD technique, HAP was detected by obtaining the characteristic diffraction maximums. Good antibacterial activity of the composite coating loaded with antibiotic (HAP/CS/Gent) was confirmed against Staphylococcus aureus and Escherichia coli, pointing to the high potential for bioapplication. Introduction of gentamicin in HAP/CS/Gent coating caused very mild cytotoxicity in the tested cell lines MRC-5 and L929. MTT testing was used to evaluate cell viability, and HAP/CS was classified as noncytotoxic.en
dc.publisherAmer Chemical Soc, Washington
dc.relationBasic Science Research Program of the Ministry of Education, Science and Technology of Korea - 2018R1A2B5A02023190
dc.rightsrestrictedAccess
dc.sourceACS Biomaterials Science & Engineering
dc.subjectbiocompositeen
dc.subjectcoatingsen
dc.subjectelectrophoretic depositionen
dc.subjectsurface analysisen
dc.subjectantibacterial activityen
dc.titleGentamicin-Loaded Bioactive Hydroxyapatite/Chitosan Composite Coating Electrodeposited on Titaniumen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractОдовић, Јадранка; Рхее, Кyонг Yоп; Цревар-Сакач, Милкица; Јанковић, Aна; Мишковић-Станковић, Весна; Стевановић, Милена; Стојановић, Јовица; Вукашиновић-Секулић, Маја; Којић, Весна; Досић, Марија;
dc.citation.volume4
dc.citation.issue12
dc.citation.spage3994
dc.citation.epage4007
dc.citation.other4(12): 3994-4007
dc.citation.rankM21
dc.identifier.wos000453109000008
dc.identifier.doi10.1021/acsbiomaterials.8b00859
dc.identifier.scopus2-s2.0-85058300298
dc.identifier.rcubconv_4273
dc.type.versionpublishedVersion


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