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dc.creatorMilutinović, Violeta
dc.creatorNiketić, Marjan
dc.creatorUšjak, Ljuboš
dc.creatorNikolić, Dejan
dc.creatorKrunić, Aleksej
dc.creatorZidorn, Christian
dc.creatorPetrović, Silvana
dc.date.accessioned2019-09-02T12:05:26Z
dc.date.available2019-09-02T12:05:26Z
dc.date.issued2018
dc.identifier.issn0958-0344
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/3127
dc.description.abstractIntroductionHieracium s. str. represents one of the largest and most complex genera of flowering plants. As molecular genetics seems unlikely to disentangle intricate relationships within this reticulate species complex, analysis of flavonoids and phenolic acids, known as good chemosystematic markers, promise to be more reliable. Data about pharmacological activity of Hieracium species are scarce. ObjectiveEvaluation of the chemosystematic significance of flavonoids and phenolic acids of methanol extracts of aerial flowering parts of 28 Hieracium species from the Balkans. Additionally, investigation of antioxidant potentials of the extracts. MethodsComparative qualitative and quantitative analysis of flavonoids and phenolic acids was performed by LC-MS. Multivariate statistical data analysis included non-metric multidimensional scaling (nMDS), unweighted pair-group arithmetic averages (UPGMA) and principal component analysis (PCA). Antioxidant activity was evaluated using three colorimetric tests. ResultsDominant phenolics in almost all species were luteolin type flavonoids, followed by phenolic acids. Although the investigated Hieracium species share many compounds, the current classification of the genus was supported by nMDS and UPGMA analyses with a good resolution to the group level. Hieracium naegelianum was clearly separated from the other investigated species. Spatial and ecological distances of the samples were likely to influence unexpected differentiation of some groups within H. sect. Pannosa. The vast majority of dominant compounds significantly contributed to differences between taxa. The antioxidant potential of the extracts was satisfactory and in accordance with their phenolics composition. ConclusionsComparative LC-MS analysis demonstrated that flavonoids and phenolic acids are good indicators of chemosystematic relationships within Hieracium, particularly between non-hybrid species and groups from the same location. Copyrighten
dc.publisherWiley, Hoboken
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173021/RS//
dc.rightsrestrictedAccess
dc.sourcePhytochemical Analysis
dc.subjectHieraciumen
dc.subjectLC-MSen
dc.subjectphenolicsen
dc.subjectchemosystematicen
dc.subjectantioxidant activityen
dc.titleMethanol Extracts of 28 Hieracium Species from the Balkan Peninsula - Comparative LC-MS Analysis, Chemosystematic Evaluation of their Flavonoid and Phenolic Acid Profiles and Antioxidant Potentialsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractУшјак, Љубош; Зидорн, Цхристиан; Крунић, Aлексеј; Милутиновић, Виолета; Петровић, Силвана; Николић, Дејан; Никетић, Марјан;
dc.citation.volume29
dc.citation.issue1
dc.citation.spage30
dc.citation.epage47
dc.citation.other29(1): 30-47
dc.citation.rankM22
dc.identifier.wos000416940000004
dc.identifier.doi10.1002/pca.2712
dc.identifier.pmid28766842
dc.identifier.scopus2-s2.0-85026667898
dc.identifier.rcubconv_4008
dc.type.versionpublishedVersion


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