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Čvrste disperzije sa karbamazepinom: Optimizacija formulacija, karakterizacija i ispitivanje dugoročne stabilnosti

dc.creatorKrstić, Marko
dc.creatorLukić, I
dc.creatorBušatlić, A
dc.creatorLazarević, N
dc.creatorVasiljević, Dragana
dc.date.accessioned2019-09-02T12:05:33Z
dc.date.available2019-09-02T12:05:33Z
dc.date.issued2018
dc.identifier.issn0367-598X
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/3130
dc.description.abstractSolid dispersions are defined as dispersions of one or more active pharmaceutical ingredients in inert solid-state carriers. They are made with the aim to increase solubility and the dissolution rate of low solubility active pharmaceutical ingredients, with the subsequent increase in their bioavailability. The aim of this study was the development and optimization of solid dispersion formulations with carbamazepine, using D-optimal experimental design, in order to increase the dissolution rate of the selected model drug. By using the method of experimental mixture design, solid dispersions were formulated by varying the ratio of carbamazepine (30-50 %), Gelucire® 44/14 (20-40 %) and Soluplus® polymer (30-50 %) (input parameters). Sixteen formulations were made and used for in vitro testing of the carbamazepine dissolution rate. The observed output parameters were the percentages of carbamazepine released after 10, 20, 30, 45, and 60 minutes. After the data analysis, three test formulations were chosen from different parts of the optimization area. They were prepared and the carbamazepine dissolution rate was determined, followed by stability assessment for 24 months under ambient conditions (25 °C, 40 % RH). The highest dissolution rate of carbamazepine from solid dispersions (more than 80 % in 30 minutes) was achieved at the carbamazepine mass fraction of about 40 %, Soluplus® of about 45 % and Gelucire® 44/14 of about 25 %. Comparing the predicted and the experimental obtained release rate profiles of carbamazepine from the three prepared optimized formulations, a significant compliance of the results was observed (f1<15; f2 >50). The application of the PAMPA (Parallel Artificial-Membrane Permeability Assay) test has shown that carbamazepine premeability was maintained and mildly increased in two out of the three tested optimzed solid state formulations. Raman spectroscopy, FT-IR and DSC analyes showed that in the three optimized solid dispersions, after preparation and 24 months of storage, interactions between carbamazepine and the excipients were not present and that carbamazepine remained in the single pharmacologically active crystal polymorph form III. Proper selection of solid dispersion proportions of carbamazepine, Gelucire® 44/14 and Soluplus® may significantly increase the dissolution rate of the active substance, and the method of experimental mixture design can be successfully used for optimization of these formulations.en
dc.publisherSavez hemijskih inženjera, Beograd
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/34007/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/171032/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceHemijska industrija
dc.subjectCarbamazepineen
dc.subjectExperimental designen
dc.subjectFormulation optimizationen
dc.subjectIn vitro releaseen
dc.subjectPhysical stabilityen
dc.subjectSolid dispersionsen
dc.titleSolid dispersions with carbamazepine: Optimization of formulation, characterization and examination of long-term stabilityen
dc.titleČvrste disperzije sa karbamazepinom: Optimizacija formulacija, karakterizacija i ispitivanje dugoročne stabilnostisr
dc.typearticle
dc.rights.licenseBY-NC-ND
dcterms.abstractБушатлић, A; Лукић, И; Крстић, Марко; Васиљевић, Драгана; Лазаревић, Н; Чврсте дисперзије са карбамазепином: Оптимизација формулација, карактеризација и испитивање дугорочне стабилности; Чврсте дисперзије са карбамазепином: Оптимизација формулација, карактеризација и испитивање дугорочне стабилности;
dc.citation.volume72
dc.citation.issue4
dc.citation.spage191
dc.citation.epage204
dc.citation.other72(4): 191-204
dc.citation.rankM23
dc.identifier.wos000440182100003
dc.identifier.doi10.2298/HEMIND171025013K
dc.identifier.scopus2-s2.0-85054033802
dc.identifier.fulltexthttps://farfar.pharmacy.bg.ac.rs//bitstream/id/1719/3128.pdf
dc.type.versionpublishedVersion


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