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dc.creatorBanjac, Lidija
dc.creatorBanjac, Goran
dc.creatorKotur-Stevuljević, Jelena
dc.creatorSpasojević-Kalimanovska, Vesna
dc.creatorGojković, Tamara
dc.creatorBogavac-Stanojević, Nataša
dc.creatorJelić-Ivanović, Zorana
dc.creatorBanjac, Gorica
dc.date.accessioned2019-09-02T12:05:40Z
dc.date.available2019-09-02T12:05:40Z
dc.date.issued2018
dc.identifier.issn0353-9466
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/3135
dc.description.abstractPremature infants are susceptible to oxidative stress that causes neonatal disease such as retinopathy of prematurity (ROP). Oxidative stress is an imbalance between the production of pro-oxidants and the ability of the body to detoxify their harmful effects by antioxidants. The proliferative phase 2 ROP occurs at around 33(rd) postmenstrual week (pmw). The purpose of our study was to evaluate the pro-oxidant/antioxidant status in preterm infants at 33rd pmw. The study included 59 premature infants. ROP was classified according to the International Classification of Retinopathy of Prematurity. Total oxidative status (TOS), total antioxidant status (TAS), malondialdehyde (MDA) and paraoxonase 1 (PON1) activity were determined spectrophotometrically. The values of the pro-oxidants TOS and MDA were significantly higher in infants with ROP as compared to infants without ROP (p lt 0.05 both). There were no significant differences in the values of TAS and PON1 between the infants with and without ROP. According to study results, TOS and MDA are good markers of oxidative stress, whereas TAS and PON1 activity are unreliable in assessing antioxidant protection.en
dc.publisherSestre Milosrdnice Univ Hospital, Zagreb
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175035/RS//
dc.rightsopenAccess
dc.sourceActa Clinica Croatica
dc.subjectReactive oxygen speciesen
dc.subjectAntioxidantsen
dc.subjectRetinopathy of prematurityen
dc.subjectInfanten
dc.subjectprematureen
dc.subjectOxidative stressen
dc.titlePro-oxidants and antioxidants in retinopathy of prematurity [Pro-oksidansi i antioksidansi u prematurnoj retinopatiji]en
dc.typearticle
dc.rights.licenseBY-NC-ND
dcterms.abstractБањац, Горан; Котур-Стевуљевић, Јелена; Спасојевић-Калимановска, Весна; Бањац, Горица; Богавац-Станојевић, Наташа; Гојковић, Тамара; Јелић-Ивановић, Зорана; Бањац, Лидија;
dc.citation.volume57
dc.citation.issue3
dc.citation.spage458
dc.citation.epage463
dc.citation.other57(3): 458-463
dc.citation.rankM23
dc.identifier.wos000456818000008
dc.identifier.doi10.20471/acc.2018.57.03.08
dc.identifier.pmid31168178
dc.identifier.scopus2-s2.0-85061601144
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/1721/3133.pdf
dc.identifier.rcubconv_4303
dc.type.versionpublishedVersion


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