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Membrane PD-L1 expression and soluble PD-L1 plasma levels in idiopathic pulmonary fibrosis-a pilot study
dc.creator | Jovanović, Dragana | |
dc.creator | Milenković, Marina | |
dc.creator | Kotur-Stevuljević, Jelena | |
dc.creator | Marković, Jelena | |
dc.creator | Ceriman, Vesna | |
dc.creator | Kontić, Milica | |
dc.creator | Skodrić-Trifunović, Vesna | |
dc.date.accessioned | 2019-09-02T12:05:41Z | |
dc.date.available | 2019-09-02T12:05:41Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 2072-1439 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/3136 | |
dc.description.abstract | Background: Idiopathic pulmonary fibrosis (IPF) has common risk factors with cancer and significant similarities in the pathobiology process, both diseases having poor outcomes. Immune checkpoint PD-L1 has become the target of checkpoint inhibitory therapy that unleashes antitumor T cells and has revolutionized cancer treatment. This is a pilot study exploring membrane immune checkpoint PD-L1 expression in human IPF lung tissue samples and its soluble form, soluble PD-L1 (sPD-L1) plasma concentrations in IPF patients, in order to investigate potential role of PD-L1 as an IPF biomarker. Methods: Twelve human IPF lung tissue samples (formalin-fixed, paraffin-embedded) obtained by surgical biopsy, have been tested for PD-L1 expression by PD-L1 IHC 22C3 pharmDx assay, while plasma samples for examination of sPD-L1 forms, PD-L1 (B7-H1/CD274) blood concentration, originated from 23 patients with IPE who did not undergo surgical biopsy. Results: Membrane PD-L1 expression in IPF lung tissue samples was positive to overexpression of PD-L1 in 9 samples out of 12. Only very few cells in the interstitium have shown a discrete PD-L1 expression, but not of a membrane type. As for sPD-L1 forms, we have found elevated concentrations of sPD-L1 in the serum of IPF patients 314.3 ng/L (117.7-483.1 ng/L), significantly higher compared with healthy control group 91.0 ng/L (52.4-119.7 ng/L), P lt 0.01. Conclusions: For IPF with PD-L1 expression on alveolar macrophages, further studies are necessary to elucidate this phenomenon. Serum sPD-1/PD-L1 is easily detected in clinical practice and should be further evaluated as a potential prognostic or/and predictive biomarker in IPF. | en |
dc.publisher | Ame Publ Co, Shatin | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175046/RS// | |
dc.rights | openAccess | |
dc.source | Journal of Thoracic Disease | |
dc.subject | Idiopathic pulmonary fibrosis (IPF) | en |
dc.subject | membrane PD-L1 expression | en |
dc.subject | soluble PD-L1 | en |
dc.title | Membrane PD-L1 expression and soluble PD-L1 plasma levels in idiopathic pulmonary fibrosis-a pilot study | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Контић, Милица; Марковић, Јелена; Котур-Стевуљевић, Јелена; Цериман, Весна; Јовановић, Драгана; Скодрић-Трифуновић, Весна; Роксандић-Миленковић, Марина; | |
dc.citation.volume | 10 | |
dc.citation.issue | 12 | |
dc.citation.spage | 6660 | |
dc.citation.epage | 6669 | |
dc.citation.other | 10(12): 6660-6669 | |
dc.citation.rank | M23 | |
dc.identifier.wos | 000456834700070 | |
dc.identifier.doi | 10.21037/jtd.2018.11.16 | |
dc.identifier.pmid | 30746211 | |
dc.identifier.scopus | 2-s2.0-85059540040 | |
dc.identifier.fulltext | https://farfar.pharmacy.bg.ac.rs//bitstream/id/1722/3134.pdf | |
dc.type.version | publishedVersion |