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Body mass index is independently associated with xanthine oxidase activity in overweight/obese population

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2020
Authors
Klisić, Aleksandra
Kocić, Gordana
Kavarić, Nebojša
Jovanović, M
Stanišić, Verica
Ninić, Ana
Article (Published version)
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Abstract
Purpose: The pathophysiological mechanism of the relationship between xanthine oxidase (XO) activity and obesity has not been completely elucidated. Since inflammation and oxidative stress are regarded as key determinants of enlarged adipose tissue, we aimed to investigate the association between oxidative stress (as measured with XO activity), inflammation [as measured with high-sensitivity C-reactive protein (hsCRP)] and obesity [as measured with body mass index (BMI)]. In addition, we wanted to examine whether hsCRP itself plays an independent role in XO activity increase or it is only mediated through obesity. Methods: A total of 118 overweight/obese volunteers (mean age 54.76 ± 15.13 years) were included in the current cross-sectional study. Anthropometric, biochemical parameters, and blood pressure were obtained. Results: Significant differences between age, BMI, waist circumference, concentrations of uric acid and hsCRP, as well as xanthine dehydrogenase (XDH) activities were ev...ident among XO tertile groups. Multiple linear regression analysis revealed that BMI (beta = 0.241, p = 0.012) and XDH (beta = − 0.489, p < 0.001) are the independent predictors of XO activity (R2-adjusted = 0.333), whereas hsCRP lost its independent role in XO activity prediction. Conclusion: Obesity (as determined with increased BMI) is an independent predictor of high XO activity in overweight/obese population. Level of Evidence: Level V: cross-sectional descriptive study.

Keywords:
Inflammation / Obesity / Oxidative stress / Xanthine oxidase
Source:
Eating and Weight Disorders, 2020, 25, 1, 9-15
Publisher:
  • Springer International Publishing
Projects:
  • Interactive role of dyslipidemia, oxidative stress and inflammation in atherosclerosis and other diseases: genetic and biochemical markers (RS-175035)

DOI: 10.1007/s40519-018-0490-5

ISSN: 1124-4909

WoS: 000511913200002

Scopus: 2-s2.0-85042382753
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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/3142
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  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy

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